과제정보
This research was supported by the Bio & Medical Technology Development Program of the National Research Foundation (NRF) funded by the Korean government (MSIT) (No. NRF-2017M3A9B4061887 and SRC 2017R1A5A1014560). The authors would like to express their gratitude to Professor In-Gyu Kim of Seoul National University College of Medicine for providing the hUC-MSCs.
참고문헌
- Acciani, T.H., Brandt, E.B., Khurana Hershey, G.K., and Le Cras, T.D. (2013). Diesel exhaust particle exposure increases severity of allergic asthma in young mice. Clin. Exp. Allergy 43, 1406-1418. https://doi.org/10.1111/cea.12200
- Backman, H., Jansson, S.A., Stridsman, C., Eriksson, B., Hedman, L., Eklund, B.M., Sandstrom, T., Lindberg, A., Lundback, B., and Ronmark, E. (2018). Severe asthma among adults: prevalence and clinical characteristics. Eur. Respir. J. 52(Suppl 62), PA3918.
- Boldrini-Leite, L.M., Michelotto, P.V., Jr., de Moura, S.A.B., Capriglione, L.G.A., Barussi, F.C.M., Fragoso, F.Y.I., Senegaglia, A.C., and Brofman, P.R.S. (2020). Lung tissue damage associated with allergic asthma in BALB/c mice could be controlled with a single injection of mesenchymal stem cells from human bone marrow up to 14 d after transplantation. Cell Transplant. 29, 963689720913254.
- Bonfield, T.L., Koloze, M., Lennon, D.P., Zuchowski, B., Yang, S.E., and Caplan, A.I. (2010). Human mesenchymal stem cells suppress chronic airway inflammation in the murine ovalbumin asthma model. Am. J. Physiol. Lung Cell. Mol. Physiol. 299, L760-L770. https://doi.org/10.1152/ajplung.00182.2009
- Brandt, E.B., Biagini Myers, J.M., Acciani, T.H., Ryan, P.H., Sivaprasad, U., Ruff, B., LeMasters, G.K., Bernstein, D.I., Lockey, J.E., LeCras, T.D., et al. (2015). Exposure to allergen and diesel exhaust particles potentiates secondary allergen-specific memory responses, promoting asthma susceptibility. J. Allergy Clin. Immunol. 136, 295-303.e7. https://doi.org/10.1016/j.jaci.2014.11.043
- Braza, F., Dirou, S., Forest, V., Sauzeau, V., Hassoun, D., Chesne, J., Cheminant-Muller, M.A., Sagan, C., Magnan, A., and Lemarchand, P. (2016). Mesenchymal stem cells induce suppressive macrophages through phagocytosis in a mouse model of asthma. Stem Cells 34, 1836-1845. https://doi.org/10.1002/stem.2344
- Cahill, E.F., Tobin, L.M., Carty, F., Mahon, B.P., and English, K. (2015). Jagged-1 is required for the expansion of CD4+ CD25+ FoxP3+ regulatory T cells and tolerogenic dendritic cells by murine mesenchymal stromal cells. Stem Cell Res. Ther. 6, 19. https://doi.org/10.1186/s13287-015-0021-5
- Castro, L.L., Kitoko, J.Z., Xisto, D.G., Olsen, P.C., Guedes, H.L.M., Morales, M.M., Lopes-Pacheco, M., Cruz, F.F., and Rocco, P.R.M. (2020). Multiple doses of adipose tissue-derived mesenchymal stromal cells induce immunosuppression in experimental asthma. Stem Cells Transl. Med. 9, 250-260. https://doi.org/10.1002/sctm.19-0120
- Chae, D., Han, S., Lee, M., and Kim, S. (2021). Genome edited Sirt1-overexpressing human mesenchymal stem cells exhibit therapeutic effects in treating collagen-induced arthritis. Mol. Cells 44, 245-253. https://doi.org/10.14348/molcells.2021.0037
- Court, A.C., Le-Gatt, A., Luz-Crawford, P., Parra, E., Aliaga-Tobar, V., Batiz, L.F., Contreras, R.A., Ortuzar, M.I., Kurte, M., Elizondo-Vega, R., et al. (2020). Mitochondrial transfer from MSCs to T cells induces Treg differentiation and restricts inflammatory response. EMBO Rep. 21, e48052.
- Cruz, F.F., Borg, Z.D., Goodwin, M., Sokocevic, D., Wagner, D.E., Coffey, A., Antunes, M., Robinson, K.L., Mitsialis, S.A., Kourembanas, S., et al. (2015). Systemic administration of human bone marrow-derived mesenchymal stromal cell extracellular vesicles ameliorates Aspergillus hyphal extract-induced allergic airway inflammation in immunocompetent mice. Stem Cells Transl. Med. 4, 1302-1316. https://doi.org/10.5966/sctm.2014-0280
- de Castro, L.L., Xisto, D.G., Kitoko, J.Z., Cruz, F.F., Olsen, P.C., Redondo, P.A.G., Ferreira, T.P.T., Weiss, D.J., Martins, M.A., Morales, M.M., et al. (2017). Human adipose tissue mesenchymal stromal cells and their extracellular vesicles act differentially on lung mechanics and inflammation in experimental allergic asthma. Stem Cell Res. Ther. 8, 151. https://doi.org/10.1186/s13287-017-0600-8
- Fallon, P.G. and Schwartz, C. (2020). The high and lows of type 2 asthma and mouse models. J. Allergy Clin. Immunol. 145, 496-498. https://doi.org/10.1016/j.jaci.2019.11.031
- Fan, X.L., Zhang, Y., Li, X., and Fu, Q.L. (2020). Mechanisms underlying the protective effects of mesenchymal stem cell-based therapy. Cell. Mol. Life Sci. 77, 2771-2794. https://doi.org/10.1007/s00018-020-03454-6
- GBD 2016 Disease and Injury Incidence and Prevalence Collaborators (2017). Global, regional, and national incidence, prevalence, and years lived with disability for 328 diseases and injuries for 195 countries, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016. Lancet 390, 1211-1259. https://doi.org/10.1016/S0140-6736(17)32154-2
- Goodwin, M., Sueblinvong, V., Eisenhauer, P., Ziats, N.P., LeClair, L., Poynter, M.E., Steele, C., Rincon, M., and Weiss, D.J. (2011). Bone marrowderived mesenchymal stromal cells inhibit Th2-mediated allergic airways inflammation in mice. Stem Cells 29, 1137-1148. https://doi.org/10.1002/stem.656
- Hong, G.H., Kwon, H.S., Lee, K.Y., Ha, E.H., Moon, K.A., Kim, S.W., Oh, W., Kim, T.B., Moon, H.B., and Cho, Y.S. (2017). hMSCs suppress neutrophil-dominant airway inflammation in a murine model of asthma. Exp. Mol. Med. 49, e288. https://doi.org/10.1038/emm.2016.135
- Inamdar, A.C. and Inamdar, A.A. (2013). Mesenchymal stem cell therapy in lung disorders: pathogenesis of lung diseases and mechanism of action of mesenchymal stem cell. Exp. Lung Res. 39, 315-327. https://doi.org/10.3109/01902148.2013.816803
- Jeong, E.M., Shin, J.W., Lim, J., Kim, J.H., Kang, H., Yin, Y., Kim, H.M., Kim, Y., Kim, S.G., Kang, H.S., et al. (2019). Monitoring glutathione dynamics and heterogeneity in living stem cells. Int. J. Stem Cells 12, 367-379. https://doi.org/10.15283/ijsc18151
- Kavanagh, H. and Mahon, B.P. (2011). Allogeneic mesenchymal stem cells prevent allergic airway inflammation by inducing murine regulatory T cells. Allergy 66, 523-531. https://doi.org/10.1111/j.1398-9995.2010.02509.x
- Keating, A. (2012). Mesenchymal stromal cells: new directions. Cell Stem Cell 10, 709-716. https://doi.org/10.1016/j.stem.2012.05.015
- Khurana, S., Bush, A., and Holguin, F. (2020). Management of severe asthma: summary of the European Respiratory Society/American Thoracic Society task force report. Breathe (Sheff.) 16, 200058. https://doi.org/10.1183/20734735.0058-2020
- Kim, H.Y., DeKruyff, R.H., and Umetsu, D.T. (2010). The many paths to asthma: phenotype shaped by innate and adaptive immunity. Nat. Immunol. 11, 577-584. https://doi.org/10.1038/ni.1892
- Kim, H.Y., Umetsu, D.T., and Dekruyff, R.H. (2016). Innate lymphoid cells in asthma: will they take your breath away? Eur. J. Immunol. 46, 795-806. https://doi.org/10.1002/eji.201444557
- Kim, J., Ryu, S., and Kim, H.Y. (2021). Innate lymphoid cells in tissue homeostasis and disease pathogenesis. Mol. Cells 44, 301-309. https://doi.org/10.14348/molcells.2021.0053
- Kim, Y.S., Kokturk, N., Kim, J.Y., Lee, S.W., Lim, J., Choi, S.J., Oh, W., and Oh, Y.M. (2016). Gene profiles in a smoke-induced COPD mouse lung model following treatment with mesenchymal stem cells. Mol. Cells 39, 728-733. https://doi.org/10.14348/molcells.2016.0095
- Kurtz, A. (2008). Mesenchymal stem cell delivery routes and fate. Int. J. Stem Cells 1, 1-7. https://doi.org/10.15283/ijsc.2008.1.1.1
- Lee, S.H., Jang, A.S., Kwon, J.H., Park, S.K., Won, J.H., and Park, C.S. (2011). Mesenchymal stem cell transfer suppresses airway remodeling in a toluene diisocyanate-induced murine asthma model. Allergy Asthma Immunol. Res. 3, 205-211. https://doi.org/10.4168/aair.2011.3.3.205
- Levy, O., Kuai, R., Siren, E.M.J., Bhere, D., Milton, Y., Nissar, N., De Biasio, M., Heinelt, M., Reeve, B., Abdi, R., et al. (2020). Shattering barriers toward clinically meaningful MSC therapies. Sci. Adv. 6, eaba6884. https://doi.org/10.1126/sciadv.aba6884
- Lundback, B., Backman, H., Lotvall, J., and Ronmark, E. (2016). Is asthma prevalence still increasing? Expert Rev. Respir. Med. 10, 39-51. https://doi.org/10.1586/17476348.2016.1114417
- Luz-Crawford, P., Hernandez, J., Djouad, F., Luque-Campos, N., Caicedo, A., Carrere-Kremer, S., Brondello, J.M., Vignais, M.L., Pene, J., and Jorgensen, C. (2019). Mesenchymal stem cell repression of Th17 cells is triggered by mitochondrial transfer. Stem Cell Res. Ther. 10, 232. https://doi.org/10.1186/s13287-019-1307-9
- McCracken, J.L., Veeranki, S.P., Ameredes, B.T., and Calhoun, W.J. (2017). Diagnosis and management of asthma in adults: a review. JAMA 318, 279-290. https://doi.org/10.1001/jama.2017.8372
- Ministry of Food and Drug Safety (2014a). Considerations in Immunotoxicity Assessment of Allogenic Stem Cell Therapy Product (Cheongju: Ministry of Food and Drug Safety).
- Ministry of Food and Drug Safety (2014b). Guideline in Quality, Non-clinical and Clinical Assessment of Stem Cell Therapy Product (Cheongju: Ministry of Food and Drug Safety).
- Mirershadi, F., Ahmadi, M., Rezabakhsh, A., Rajabi, H., Rahbarghazi, R., and Keyhanmanesh, R. (2020). Unraveling the therapeutic effects of mesenchymal stem cells in asthma. Stem Cell Res. Ther. 11, 400. https://doi.org/10.1186/s13287-020-01921-2
- Moll, G., Ankrum, J.A., Kamhieh-Milz, J., Bieback, K., Ringden, O., Volk, H.D., Geissler, S., and Reinke, P. (2019). Intravascular mesenchymal stromal/stem cell therapy product diversification: time for new clinical guidelines. Trends Mol. Med. 25, 149-163. https://doi.org/10.1016/j.molmed.2018.12.006
- Munir, H. and McGettrick, H.M. (2015). Mesenchymal stem cell therapy for autoimmune disease: risks and rewards. Stem Cells Dev. 24, 2091-2100. https://doi.org/10.1089/scd.2015.0008
- Nemeth, K., Keane-Myers, A., Brown, J.M., Metcalfe, D.D., Gorham, J.D., Bundoc, V.G., Hodges, M.G., Jelinek, I., Madala, S., Karpati, S., et al. (2010). Bone marrow stromal cells use TGF-beta to suppress allergic responses in a mouse model of ragweed-induced asthma. Proc. Natl. Acad. Sci. U. S. A. 107, 5652-5657. https://doi.org/10.1073/pnas.0910720107
- Partridge, M.R. (2007). Examining the unmet need in adults with severe asthma. Eur. Respir. Rev. 16, 67-72. https://doi.org/10.1183/09059180.00010402
- Regmi, S., Pathak, S., Kim, J.O., Yong, C.S., and Jeong, J.H. (2019). Mesenchymal stem cell therapy for the treatment of inflammatory diseases: challenges, opportunities, and future perspectives. Eur. J. Cell Biol. 98, 151041. https://doi.org/10.1016/j.ejcb.2019.04.002
- Ren, G., Zhao, X., Zhang, L., Zhang, J., L'Huillier, A., Ling, W., Roberts, A.I., Le, A.D., Shi, S., Shao, C., et al. (2010). Inflammatory cytokine-induced intercellular adhesion molecule-1 and vascular cell adhesion molecule-1 in mesenchymal stem cells are critical for immunosuppression. J. Immunol. 184, 2321-2328. https://doi.org/10.4049/jimmunol.0902023
- Ryu, Y.J., Cho, T.J., Lee, D.S., Choi, J.Y., and Cho, J. (2013). Phenotypic characterization and in vivo localization of human adipose-derived mesenchymal stem cells. Mol. Cells 35, 557-564. https://doi.org/10.1007/s10059-013-0112-z
- Snelgrove, R.J., Gregory, L.G., Peiro, T., Akthar, S., Campbell, G.A., Walker, S.A., and Lloyd, C.M. (2014). Alternaria-derived serine protease activity drives IL-33-mediated asthma exacerbations. J. Allergy Clin. Immunol. 134, 583-592.e6. https://doi.org/10.1016/j.jaci.2014.02.002
- Song, X., Xie, S., Lu, K., and Wang, C. (2015). Mesenchymal stem cells alleviate experimental asthma by inducing polarization of alveolar macrophages. Inflammation 38, 485-492. https://doi.org/10.1007/s10753-014-9954-6
- Srour, N. and Thebaud, B. (2014). Stem cells in animal asthma models: a systematic review. Cytotherapy 16, 1629-1642. https://doi.org/10.1016/j.jcyt.2014.08.008
- Sun, Y.Q., Deng, M.X., He, J., Zeng, Q.X., Wen, W., Wong, D.S., Tse, H.F., Xu, G., Lian, Q., Shi, J., et al. (2012). Human pluripotent stem cell-derived mesenchymal stem cells prevent allergic airway inflammation in mice. Stem Cells 30, 2692-2699. https://doi.org/10.1002/stem.1241
- Wang, G., Zhang, S., Wang, F., Li, G., Zhang, L., and Luan, X. (2013). Expression and biological function of programmed death ligands in human placenta mesenchymal stem cells. Cell Biol. Int. 37, 137-148. https://doi.org/10.1002/cbin.10024
- Zeng, S.L., Wang, L.H., Li, P., Wang, W., and Yang, J. (2015). Mesenchymal stem cells abrogate experimental asthma by altering dendritic cell function. Mol. Med. Rep. 12, 2511-2520. https://doi.org/10.3892/mmr.2015.3706
- Zhang, L.B. and He, M. (2019). Effect of mesenchymal stromal (stem) cell (MSC) transplantation in asthmatic animal models: a systematic review and meta-analysis. Pulm. Pharmacol. Ther. 54, 39-52. https://doi.org/10.1016/j.pupt.2018.11.007