과제정보
This research was supported by grants from the National Research Foundation (NRF-2016M3A9B6916708, NRF-2020M3A9I2107294) funded by the Ministry of Science and ICT in the Republic of Korea.
참고문헌
- Wu F, Zhao S, Yu B et al (2020) A new coronavirus associated with human respiratory disease in China. Nature 579, 265-269 https://doi.org/10.1038/s41586-020-2008-3
- Zhou P, Yang X, Wang X et al (2020) A pneumonia outbreak associated with a new coronavirus of probable bat origin. Nature 579, 270-273 https://doi.org/10.1038/s41586-020-2012-7
- Richardson S, Hirsch JS, Narasimhan M et al (2020) Presenting characteristics, comorbidities, and outcomes among 5700 patients hospitalized with COVID-19 in the New York city area. JAMA 323, 2052-2059 https://doi.org/10.1001/jama.2020.6775
- Yu J, Ouyang W and Chua MLK (2020) SARS-CoV-2 transmission in cancer patients of a tertiary hospital in Wuhan. JAMA Oncol 6, 1108-1110 https://doi.org/10.1001/jamaoncol.2020.0980
- Sidaway P (2020) COVID-19 and cancer: What we know so far. Nat Rev Clin Oncol 17, 336 https://doi.org/10.1038/s41571-020-0366-2
- Bersanelli M (2020) Controversies about COVID-19 and anticancer treatment with immune checkpoint inhibitors. Immunotherapy 12, 269-273 https://doi.org/10.2217/imt-2020-0067
- Siegel RL, Miller KD and Jemal A (2020) Cancer statistics, 2020. CA Cancer J Clin 70, 7-30 https://doi.org/10.3322/caac.21590
- Russano M, Vincenzi B, Tonini G, Tonini G and Santini D (2020) Coronavirus disease 2019 or lung cancer: What should we treat? J Thorac Oncol 15, e105-106 https://doi.org/10.1016/j.jtho.2020.04.001
- Zhang H, Huang Y and Xie C (2020) The treatment and outcome of a lung cancer patient infected with severe acute respiratory syndrome coronavirus-2. J Thorac Oncol 15, e63-64 https://doi.org/10.1016/j.jtho.2020.02.025
- Hollingsworth MA and Swanson BJ (2004) Mucins in cancer: protection and control of the cell surface. Nat Rev Cancer 4, 45-60 https://doi.org/10.1038/nrc1251
- Levitin F, Stern O, Weiss M et al (2005) The MUC1 SEA module is a self-cleaving domain. J Biol Chem 280, 33374-33386 https://doi.org/10.1074/jbc.M506047200
- Macao B, Johansson DG, Hansson GC and Hard T (2006) Autoproteolysis coupled to protein folding in the SEA domain of the membrane-bound MUC1 mucin. Nat Struct Mol Biol 13, 71-76 https://doi.org/10.1038/nsmb1035
- Kufe DW (2009) Mucins in cancer: function, prognosis and therapy. Nat Rev Cancer 9, 874-885 https://doi.org/10.1038/nrc2761
- Kufe DW (2013) MUC1-C oncoprotein as a target in breast cancer: activation of signaling pathways and therapeutic approaches. Oncogene 32, 1073-1081 https://doi.org/10.1038/onc.2012.158
- Ahmad R, Rajabi H, Kosugi M et al (2011) MUC1-C oncoprotein promotes STAT3 activation in an autoinductive regulatory loop. Sci Signal 4, ra9 https://doi.org/10.1126/scisignal.2001426
- Huang L, Chen D, Liu D, Yin L, Kharbanda S and Kufe D (2005) MUC1 oncoprotein blocks glycogen synthase kinase 3beta-mediated phosphorylation and degradation of betacatenin. Cancer Res 65, 10413-10422 https://doi.org/10.1158/0008-5472.CAN-05-2474
- Awaya H, Takeshima Y, Yamasaki M and Inai K (2004) Expression of MUC1, MUC2, MUC5AC, and MUC6 in atypical adenomatous hyperplasia, bronchioloalveolar carcinoma, adenocarcinoma with mixed subtypes, and mucinous bronchioloalveolar carcinoma of the lung. Am J Clin Pathol 121, 644-653 https://doi.org/10.1309/U4WGE9EBFJN6CM8R
- Kaira K, Okumura T, Nakagawa K et al (2012) MUC1 expression in pulmonary metastatic tumors: a comparison of primary lung cancer. Pathol Oncol Res 18, 439-447 https://doi.org/10.1007/s12253-011-9465-9
- Xu M and Wang X (2017) Critical roles of mucin-1 in sensitivity of lung cancer cells to tumor necrosis factoralpha and dexamethasone. Cell Biol Toxicol 33, 361-371 https://doi.org/10.1007/s10565-017-9393-x
- Lu W, Liu X, Wang T et al (2021) Elevated MUC1 and MUC5AC mucin protein levels in airway mucus of critical Ill COVID-19 patients. J Med Virol 93, 582-584 https://doi.org/10.1002/jmv.26406
- Park BK, Kim D, Park S et al (2021) Differential signaling and virus production in Calu-3 cells and Vero cells upon SARS-CoV-infection. Biomol Ther (Seoul) 29, 273-281 https://doi.org/10.4062/biomolther.2020.226
- Gao J, McConnell MJ, Yu B et al (2009) MUC1 is a downstream target of STAT3 and regulates lung cancer cell survival and invasion. Int J Oncol 35, 337-345
- Linden SK, Sheng YH, Every AL et al (2009) MUC1 limits Helicobacter pylori infection both by steric hindrance and by acting as a releasable decoy. PLoS Pathog 5, e1000617 https://doi.org/10.1371/journal.ppat.1000617
- Thathiah A, Blobel CP and Carson DD (2003) Tumor necrosis factor-alpha converting enzyme/ADAM 17 mediates MUC1 shedding. J Biol Chem 278, 3386-3394 https://doi.org/10.1074/jbc.M208326200
- Thathiah A and Carson DD (2004) Mt1-Mmp mediates muc1 shedding independent of tace/adam17. Biochem J 382, 363-373 https://doi.org/10.1042/BJ20040513
- Nath S and Mukherjee P (2014) MUC1: a multifaceted oncoprotein with a key role in cancer progression. Trends Mol Med 20, 332-342 https://doi.org/10.1016/j.molmed.2014.02.007
- Kaira K, Nakagawa K, Ohde Y et al (2012) Depolarized MUC1 expression is closely associated with hypoxic markers and poor outcome in resected non-small cell lung cancer. Int J Surg Pathol 20, 223-232 https://doi.org/10.1177/1066896911429296
- Li Y, Dinwiddie DL, Harrod KS, Jiang Y and Kim KC (2010) Anti-inflammatory effect of MUC1 during respiratory syncytial virus infection of lung epithelial cells in vitro. Am J Physiol Lung Cell Mol Physiol 298, L558-563 https://doi.org/10.1152/ajplung.00225.2009
- Banos-Lara Mdel R, Piao B and Guerrero-Plata A (2015) Differential mucin expression by respiratory syncytial virus and human metapneumovirus infection in human epithelial cells. Mediators Inflamm 2015, 347292 https://doi.org/10.1155/2015/347292
- Luo J, Rizvi H, Preeshagul IR et al (2020) COVID-19 in patients with lung cancer. Ann Oncol 31, 1386-1396 https://doi.org/10.1016/j.annonc.2020.06.007
- Kandeel M, Yamamoto M, Al-Taher A et al (2020) Small molecule inhibitors of Middle East respiratory syndrome coronavirus fusion by targeting cavities on heptad repeat trimers. Biomol Ther (Seoul) 28, 311-319 https://doi.org/10.4062/biomolther.2019.202
- Park BK, Maharjan S, Lee SI et al (2019) Generation and characterization of a monoclonal antibody against MERS-CoV targeting the spike protein using a synthetic peptide epitope-CpG-DNA-liposome complex. BMB Rep 52, 397-402 https://doi.org/10.5483/BMBRep.2019.52.6.185
- Raina D, Ahmad R, Joshi MD et al (2009) Direct targeting of the mucin 1 oncoprotein blocks survival and tumorigenicity of human breast carcinoma cells. Cancer Res 69, 5133-5141 https://doi.org/10.1158/0008-5472.CAN-09-0854
- Shin MJ, Kim DW, Choi YJ et al (2020) PEP-1-GLRX1 protein exhibits anti-inflammatory effects by inhibiting the activation of MAPK and NF-κB pathways in Raw 264.7 cells. BMB Rep 53, 106-111 https://doi.org/10.5483/BMBRep.2020.53.2.180
- Wu G, Kim D, Kim JN et al (2018) A mucin1 C-terminal subunit-directed monoclonal antibody targets overexpressed mucin1 in breast cancer. Theranostics 8, 78-91 https://doi.org/10.7150/thno.21278
- Wu G, Maharjan S, Kim D et al (2018) A novel monoclonal antibody targets mucin1 and attenuates growth in pancreatic cancer model. Int J Mol Sci 19, 2004 https://doi.org/10.3390/ijms19072004
- Park BK, Kim J, Park S et al (2021) MERS-CoV and SARS-CoV-2 replication can be inhibited by targeting the interaction between the viral spike protein and the nucleocapsid protein. Theranostics 11, 3853-3867 https://doi.org/10.7150/thno.55647