Acknowledgement
The work was supported by the Dongnam Institute of Radio-logical and Medical Sciences (DIRAMS) grant funded by the Korea government Ministry of Science and ICT (MSIT) (No. 50495-2020 and 50498-2020).
References
- B. Dobler, F. Lorenz, H. Wertz, M. Polednik, D. Wolff, V. Steil, F. Lohr, F. Wenz, Intensity-modulated radiation therapy (IMRT) with different combinations of treatment-planning systems and linacs, Strahlenther. Onkol. 182 (2006) 481-488. https://doi.org/10.1007/s00066-006-1544-6
- B. Cho, P.R. Poulsen, P. J Keall, Real-time tumor tracking using sequential kV imaging combined with respiratory monitoring: a general framework applicable to commonly used IGRT systems, Phys. Med. Biol. 55 (2010) 3299-3316. https://doi.org/10.1088/0031-9155/55/12/003
- B.M. Prendergast, J.B. Fiveash, R.A. Popple, G.M. Clark, E.M. Thomas, D.J. Minnich, R. Jacob, S.A. Spencer, J.A. Bonner, M.C. Dobelbower, Flattening filter-free LINAC improves treatment delivery efficiency in stereotactic body radiation therapy, J. Appl. Clin. Med. Phys. 14 (2013) 64-71. https://doi.org/10.1120/jacmp.v14i3.4126
- V. Favaudon, L. Caplier, V. Monceau, F. Pouzoulet, M. Sayarath, C. Fouillade, M.-F. Poupon, I. Brito, P. Hupe, J. Bourhis, J. Hall, J.-J. Fontaine, M.-C. Vozenin, Ultrahigh dose-rate FLASH irradiation increases the differential response between normal and tumor tissue in mice, Sci. Transl. Med. 6 (2014) 245ra93. https://doi.org/10.1126/scitranslmed.3008973
- M. Buonanno, V. Grilj, D.J. Brenner, Biological effects in normal cells exposed to FLASH dose rate protons, Radiother. Oncol. 139 (2019) 51-55. https://doi.org/10.1016/j.radonc.2019.02.009
- M. Bazalova-Cartera, N. Esplen, On the capabilities of conventional x-ray tubes to deliver ultra-high (FLASH) dose rates, Med. Phys. 46 (2019) 5690-5695. https://doi.org/10.1002/mp.13858
- M.-C. Vozenin, J.H. Hendry, C.L. Limoli, Biological benefits of ultra-high dose rate FLASH radiotherapy: sleeping beauty awoken, Clin. Oncol. 31 (2019) 407-415. https://doi.org/10.1016/j.clon.2019.04.001
- J. Bourhis, W.J. Sozzi, P.G. Jorge, O. Gaide, C. Bailat, F. Duclos, D. Patin, M. Ozsahin, F. Bochud, J.-F. Germond, R. Moeckli, M.-C. Vozenin, Treatment of a first patient with FLASH-radiotherapy, Radiother. Oncol. 139 (2019) 18-22. https://doi.org/10.1016/j.radonc.2019.06.019
- J. Seco, F. Verhaegen, Monte Carlo Techniques in Radiation Therapy, CRC press, Boca Raton, 2013.
- H. Lim, Status of the DIRAMS C-band standing-wave accelerator for a radiotherapy machine, in: 9th Asia Forum for Accelerators and Detectors, Daejeon, Korea, Jan. 28-31, 2018.
- K.W. Jang, M. Lee, H. Lim, S.K. Kang, S.J. Lee, Y.M. Moon, J.Y. Kim, J.K. Kim, D.H. Jeong, Development of a wide dose-rate range electron beam irradiation system for pre-clinical study and multi-purpose applications using a research LINAC, Prog. Med. Phys. 31 (2020) 1-11. https://doi.org/10.14316/pmp.2020.31.1.1
- H. Lim, D.H. Jeong, K.W. Jang, S.K. Kang, H.C. Kim, S.H. Kim, D.E. Lee, K.H. Lee, S.J. Lee, M. Lee, Implementation of ultra-high dose-rate electron beam from 6-MeV C-band linear accelerator for preclinical study, J. Instrum. 15 (2020) P09013. https://doi.org/10.1088/1748-0221/15/09/P09013
- H. Lim, D. H. Jeong, M. Lee, M. J. Lee, S. W. Shin, J. Yi, Design of a radiotherapy machine using the 6-MeV C-band standing-wave accelerator, in: 7th International Particle Accelerator Conference, Busan, Korea, May 8-13, 2016.
- H. Lim, M. Lee, M.Y. Kim, J. Yi, M. Lee, S.K. Kang, D.J. Rhee, D.H. Jeong, Measurement of energy parameters for electron gun heater currents and output dose rate for electron beams from a prototype linac, Prog. Med. Phys. 27 (2016) 25-30. https://doi.org/10.14316/pmp.2016.27.1.25
- B. Lindskoug, A. Dahler, Collimating system for electron beams, Acta Radiol. 10 (1971) 454-463.
- K.W. Jang, M. Lee, H. Lim, S.K. Kang, S.J. Lee, S.H. Kim, D.E. Lee, H.C. Kim, D.H. Jeong, Monte Carlo simulation of an electron irradiation device for medical application of an electron linear accelerator, J. Kor. Phys. Soc. 76 (2020) 588-591. https://doi.org/10.3938/jkps.76.588
- H. Lim, D.E. Lee, M. Lee, S.W. Shin, J. Yi, D.H. Jeong, Beam-profile monitoring using the GAGG:Ce crystal for the 6 MeV electron accelerator, in: 21st International Conference on Accelerators and Beam Utilizations, Gyeongju, Korea, Nov. 15-17, 2017.
- M.R. Bieda, J.A. Antolak, K.R. Hogstrom, The effect of scattering foil parameters on electron-beam Monte Carlo calculations, Med. Phys. 28 (2001) 2027-2534.
- T. Pawlicki, D.J. Scanderberg, G. Starkschall, Hendee's Radiation Therapy Physics, fourth ed., John Wiley & Sons Inc., Hoboken, 2016.
- P. Andreo, D.T. Burns, K. Hohlfeld, M.S. Huq, T. Kanai, F. Laitano, V. Smyth, S. Vynckier, Absorbed Dose Determination in External Beam Radiotherapy: an International Code of Practice for Dosimetry Based on Standards of Absorbed Dose to Water, International Atomic Energy Agency, 2006, pp. 150-151. IAEA TRS-398.
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