대한한방부인과학회지 (The Journal of Korean Obstetrics and Gynecology)

  • 제34권3호
  • /
  • Pages.1-14
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  • 2021
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  • 1229-4292(pISSN)
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  • 2508-3619(eISSN)
대한한방부인과학회 (The Society of Korean Medicine Obstetrics and Gynecology)
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3종 한약 처방 물 추출물과 황금 에탄올 추출물에 의한 자궁내막과 태반세포 기능조절 연구

A Study on the Regulation of Endometrial and Placental Cell Function by Water Extract of 3 Types of Herbal Medicines and Ethanol Extract on Scutellariae Radix

  • 박서예 (산부인과, 건양대학교 의과대학) ;
  • 노의정 (산부인과, 건양대학교 의과대학) ;
  • 서창섭 (한약연구부, 한국한의학연구원) ;
  • 이성기 (산부인과, 건양대학교 의과대학) ;
  • 신현규 (한약연구부, 한국한의학연구원)
  • Park, Seo-Ye (Dept. of Obstetrics and Gynecology, College of Medicine, Konyang University) ;
  • Noh, Eui-Jeong (Dept. of Obstetrics and Gynecology, College of Medicine, Konyang University) ;
  • Seo, Chang-Seob (Herbal Medicine Research Division, Korea Institute of Oriental Medicine) ;
  • Lee, Sung-Ki (Dept. of Obstetrics and Gynecology, College of Medicine, Konyang University) ;
  • Shin, Hyeun-Kyoo (Herbal Medicine Research Division, Korea Institute of Oriental Medicine)
  • 투고 : 2021.07.08
  • 심사 : 2021.08.27
  • 발행 : 2021.08.27
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초록

Methods: We investigated the ability to induce decidualization of human endometrial stromal cells and invasive ability of human trophoblast cells by water extract of three types herbal medicines (Dangguijakyak-san, Siryung-tang, Antae-eum) and ethanol extract on Scutellariae Radix. Results: In the process of decidualization of endometrial stromal cells, three herbal medicines including Dangguijakyak-san, Siryung-tang, and Scutellariae Radix increased the production of decidual markers such as prolactin (PRL) and insulin-like growth factor-binding protein 1 (IGFBP1). However, Antae-eum increased mRNA levels of PRL and IGFBP and secretion of IGFBP in decidual stromal cells, but not PRL. Four herbal medicines inhibited the invasion of trophoblast cells. Conclusions: Four herbal medicines may play a role in implantation in women with reproductive failures. However, further studies are warranted to elucidate whether these medications are helpful in the maintenance of pregnancy.

키워드

과제정보

본 연구는 한국한의학연구원 기관고유 사업인 한방의료기관 한약처방 안전성·유효성 구축 사업 (KSN2021310)과 한국연구재단 기초연구사업(NRF-2017R1A6A1A03015713) 으로 부터지원 받았음.

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