Journal of the Korean Society of Safety (한국안전학회지)

The Korean Society of Safety (한국안전학회)
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The Risk Assessment of Runway Reaction in the Process of Fridel-Crafts Acylation for Synthesis Reaction

화합물 합성반응 중 Fridel - Crafts Acylation 공정에서의 폭주반응 위험성평가

  • Lee, Kwangho (Safety & Health Convergence Engineering, Soongsil University) ;
  • Kim, Wonsung (Hanmi Fine Chemical.Co.,Ltd) ;
  • Jun, Jinwoo (Safety Convergence Graduate school, Soongsil University) ;
  • Joo, Youngjong (Safety & Health Convergence Engineering, Soongsil University) ;
  • Park, Kyoshik (Safety & Health Convergence Engineering, Soongsil University)
  • 이광호 (숭실대학교 안전.보건융합공학과) ;
  • 김원성 (한미정밀화학(주) 생산Unit) ;
  • 전진우 (숭실대학교 안전융합대학원) ;
  • 주영종 (숭실대학교 안전.보건융합공학과) ;
  • 박교식 (숭실대학교 안전.보건융합공학과)
  • Received : 2021.03.18
  • Accepted : 2021.05.27
  • Published : 2021.06.30
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Abstract

Heat is generated during the synthesis and mixing process of chemical compounds due to a change in activation energy during the reaction. A runaway reaction occurs when sufficient heat is not removed during the heat control process within a reactor, rapidly increasing the temperature, reaction speed, and rate of heat generation inside the reactor. A risk assessment was executed using an RC-1 (Reaction Calorimeter) during Friedel-Crafts acylation. Friedel-Crafts acylation runs the risk of rapid heat generation during Active Pharmaceutical Ingredient (API) manufacturing; it was used to confirm the risk of a runaway reaction at each synthesis stage and during the mixing process. This study used experimental data to develop a safety efficiency improvement plan to control the risks of runaway and other exothermic reactions, which was implemented at the production site of a chemical plant.

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References

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