Journal of Veterinary Clinics (한국임상수의학회지)

The Korean Society of Veterinary Clinics (한국임상수의학회)
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Application of Topical Madecassoside Cream in Dogs and Cats with Skin Diseases

  • Ro, Woong-bin (Laboratory of Veterinary Internal Medicine, College of Veterinary Medicine, Konkuk University) ;
  • Kang, Min-hee (Laboratory of Veterinary Internal Medicine, College of Veterinary Medicine, Konkuk University) ;
  • Song, Doo-won (Laboratory of Veterinary Internal Medicine, College of Veterinary Medicine, Konkuk University) ;
  • Kim, Heyong-seok (Laboratory of Veterinary Internal Medicine, College of Veterinary Medicine, Konkuk University) ;
  • Lee, Ga-won (Laboratory of Veterinary Internal Medicine, College of Veterinary Medicine, Konkuk University) ;
  • Kang, Hyun-min (Laboratory of Veterinary Internal Medicine, College of Veterinary Medicine, Konkuk University) ;
  • Kim, Jong-won (Laboratory of Veterinary Internal Medicine, College of Veterinary Medicine, Konkuk University) ;
  • Park, Su-bin (Laboratory of Veterinary Internal Medicine, College of Veterinary Medicine, Konkuk University) ;
  • Jeon, Jin-ha (Laboratory of Veterinary Internal Medicine, College of Veterinary Medicine, Konkuk University) ;
  • Keum, Jong-seon (Laboratory of Veterinary Internal Medicine, College of Veterinary Medicine, Konkuk University) ;
  • Park, Won-keun (Yonggang Animal Hospital) ;
  • Ko, Jin (Songjeong Animal Medical Center) ;
  • Sim, Sue-kyoung (Jayeonen Animal Clinic) ;
  • Lee, Hyun-Jung (Department of Animal, Veterinary and Food Sciences, University of Idaho) ;
  • Park, Hee-myung (Laboratory of Veterinary Internal Medicine, College of Veterinary Medicine, Konkuk University)
  • Received : 2020.11.20
  • Accepted : 2020.12.05
  • Published : 2021.04.30
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Abstract

Madecassoside, an active ingredient extracted from Centella asiatica, is used for treatment of various skin disorders in humans. However, the effect of madecassoside on the skin of dogs and cats has not been studied yet. The purpose of this study was to evaluate clinical efficacy of topical madecassoside cream in dogs and cats with skin diseases. A total of twenty-one dogs and ten cats with various skin diseases were included in the study. The 1% topical madecassoside cream was applied to the animal's skin lesion at least once a day for 7 days, and the skin condition was evaluated before the application of madecassoside cream (day 0) and 7 days after the application (day 7). The skin condition was scored by five clinical indices: canine atopic dermatitis extent and severity index-4 (CADESI-4), coat condition, pruritus, scale, and general condition. In dogs, all five clinical indices (CADESI-4, coat condition, pruritus, scale, and general condition) were significantly decreased on day 7 compared to those on day 0 (p < 0.0001, p < 0.05, p < 0.001, p < 0.01, and p < 0.05, respectively). In cats, the CADESI-4 and scale were significantly decreased on day 7 compared to those on day 0 (p < 0.01 and p < 0.05, respectively). No adverse effects were observed during the trial period in the dogs and cats included in this study. The results of this study demonstrate that the topical madecassoside cream is applicable to skin lesions in dogs and cats.

Keywords

References

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