DOI QR코드

DOI QR Code

A study to effectiveness the usefulness of skin patches containing chlorogenic acid and garcinia

클로로겐산이 함유된 피부 패치의 유용성 평가를 위한 연구

  • 신주연 (경북대학교) ;
  • 고결 (KH메디케어) ;
  • 권병안 (웨스트민스터대학원대학교 카이로건강교육학과)
  • Received : 2020.09.23
  • Accepted : 2021.03.20
  • Published : 2021.03.28

Abstract

The purpose of study was to evaluate the usefulness a skin patch containing chlorogenic acid to the skin to identify changes in body fat and weight. 16 volunteers, consisting of 8 experimental groups and 8 control groups, participated in the study, and the study period was conducted for 4 weeks from Aug 03, 2020 to Aug 31, 2020. As a result of the inter-group effect test, there was no significant difference in body fat (F=4.38, p<.055), but it can be said that the experimental group had a positive effect because the difference in posterior score was larger than that of the control group. In the change of body weight, it was found that there was a significant difference in weight loss in the experimental group (F=9.43, p<.008). It will be meaningful as a preliminary study applying patches to studies related to obesity, and we hope that the results of the study will be used as basic data for research on patch materials in the future.

본 연구의 목적은 클로로겐산이 함유된 피부 패치를 피부에 부착하여 체지방과 체중에 미치는 변화를 규명하여, 유용성을 평가하는 것이다. 시험군 8명, 대조군 8명으로 총 16명의 대상자가 연구에 참여하였고, 연구 기간은 2020년 08월 03일부터 2020년 08월 31일까지 4주간 실시하였다. 군-간 효과검정 결과 체지방의 변화는 전체적으로 유의한 차이가 없었으나(F=4.38, p<.055), 1주 후와 4주 후 검사에서는 의미있는 변화(p<.001)가 있었다. 또한, 체중은 유의미한 차이로 시험군이 대조군보다 체중 감소가 큰 것으로 나타났다(F=9.43, p<.008). 이번 연구의 결과는 비만 관련 연구에 패치를 적용한 예비연구로써 의미가 있다고 할 수 있으며, 연구의 결과가 향후 연구될 피부 패치 연구의 기초 자료로 활용될 수 있을 것으로 판단된다.

Keywords

References

  1. World Health Organization. (2000). Obesity: preventing and managing the global epidemic (No. 894). World Health Organization.
  2. G. A. Bray. (2004). Medical consequences of obesity. The Journal of Clinical Endocrinology & Metabolism, Volume, 89(6): 2583-2589. https://doi.org/10.1210/jc.2004-0535.
  3. https://knhanes.cdc.go.kr/knhanes/sub03/sub03_02_05.do, Ministry of health and welfare, Korea National Health and Nutrition Examination Survey, 2010-2018.
  4. K. J. Kim, S. K. Park. (2006). Changes in major chemical constituents of green coffee beans during the roasting. Korean Journal of Food Science and Technology, 38(2), 153-158.
  5. T. Ranheim & B. Halvorsen. (2005). Coffee consumption and human health-beneficial or detrimental-Mechanisms for effects of coffee consumption on different risk factors for cardiovascular disease and type 2 diabetes mellitus. Molecular nutrition & food research, 49(3), 274-284.. https://doi.org/10.1002/mnfr.200400109.
  6. J. A. Greenberg, C. N. Boozer & A. Geliebter. (2006). Coffee, diabetes, and weight control. The American journal of clinical nutrition, 84(4), 682-693. https://doi.org/10.1093/ajcn/84.4.682
  7. R. M. Van Dam & E. J. Feskens. (2002). Coffee consumption and risk of type2 diabetes mellitus. Lancet 360(9344): 1477-1478. doi: 10.1016/S0140-6736(02)11436-X.
  8. A. Farah, M. Monteiro, C. M. Donangelo & S. Lafay. (2008). Chlorogenic acids from green coffee extract are highly bioavailable in humans. The Journal of nutrition, 138(12), 2309-2315. https://doi.org/10.3945/jn.108.095554
  9. A. Suzuki, D. Kagawa, R. Ochiai, I. Tokimitsu & I. Saito. (2002). Green coffee bean extract and its metabolites have a hypotensive effect in spontaneously hypertensive rats. Hypertension Research, 25(1), 99-107. Doi: https://doi.org/10.1291/hypres.25.99
  10. R. Ochiai, H. Jokura, A. Suzuki, I. Tokimitsu, M. Ohishi, N. Komai, H. Rakugi & T. Ogihara. (2004). Green coffee bean extract improves human vasoreactivity. Hypertens Res, 27(10): 731-737. Doi: https://doi.org/10.1291/hypres.27.731.
  11. H. E. Ghadieh, Z. N. Smiley, M. W. Kopfman, M. G. Najjar, M. J. Hake & S. M. Najjar. (2015). Chlorogenic acid/chromium supplement rescues diet-induced insulin resistance and obesity in mice. Nutrition & Metabolism, 12(19).
  12. S. H. Yoon. (2020). Effect and Safety of Combined Treatment of Gambihwanand Garcinia Cambogia on Weight Loss: A Retrospective Observational Study, Journal of Korean Medicine for Obesity Research 20(1):31-39. https://doi.org/10.15429/jkomor.2020.20.1.31.
  13. G. Marti-Mestres(2007), The "in vitro" percutaneous penetration of three antioxidant compounds. International Journal of Pharmaceutics, 331, 139-144.. Doi :10.1016/j.ijpharm.2006.09.020
  14. Z. Wang & S.Lin (2018). Chlorogenic acid alleviates obesity and modulates gut microbiota in high-fat-fed mice. NFood Sci Nutr.,579-588. Doi : 10.1002/fsn3.868.
  15. J. H. Lee. (2017). The effect of taping therapy on knee pain and depression in elderly women. Journal of the Korean Academic-Industrial Technology Society, 18(2), 619-624. DOI: https://doi.org/10.5762/KAIS.2017.18.2.619.
  16. M. N. Pastore, Y. N. Kalia, M. Horstmann., (2015). Roberts MS. Transdermal patches: history, development and pharmacology. British Journal of Pharmacology. 172(9):2179-209. doi: 10.1111/bph.13059.
  17. J. E. Rose, M. E. Jarvik & K. D. Rose. (1984). Transdermal administration of nicotine. Drug and alcohol dependence, 13(3), 209-213. https://doi.org/10.1016/0376-8716(84)90061-9..
  18. D. A. Sica & R. Grubbs. (2005). Transdermal clonidine: therapeutic considerations. The Journal of Clinical Hypertension, 7(9), 558-562. https://doi.org/10.1111/j.1524-6175.2005.04133.x.
  19. F. S. MacMillan, H. H. Reller & F. H. Synder (1964). The antiperspirant action of topically applied anticholinergics.. The Journal of Investigative Dermatology, 43, 363-377. DOI: 10.1038/jid.1964.167.
  20. Y. Zhang, Q. Liu, J. Yu, S. Yu∥, J. Wang, L. Qiang, & Z. Gu., (2017). Locally Induced Adipose Tissue Browning by Microneedle Patch for Obesity Treatment. ACS Nano, 9223-9230. https://doi.org/10.1021/acsnano.7b04348.
  21. Jeffrey M Friedman(2009). Obesity: Causes and control of excess body fat. Nature. 21;459(7245):340-2. doi: 10.1038/459340a.
  22. D. K. Han, H. N. Yang., & J. H. Seo. (2018). The Effect of 12 Weeks of Combined Training on Body Composition, Health-Related Physical Fitness, and Bone Mineral Density of Obese and Osteoporotic Intellectual Disabilities-Case study. Journal of Digital Convergence, 16(2), 375-383. https://doi.org/10.14400/JDC.2018.16.2.375
  23. S. S. Kim, (2012). Influences of Aerobic Exercise Training and Half Bath on Blood Component, Cardiorespiratory Function, and Vascular Compliance of Middle-aged Obese Men PDF icon. Journal of Digital Convergence, 10(11), 541-550. UCI : G704-002010.2012.10.11.037. https://doi.org/10.14400/JDPM.2012.10.11.541
  24. W. H. Kim, S. S. Kim.,(2016). The effects of combined exercise training 12weeks on body composition and basic physical strength in obese college women PDF icon. Journal of Digital Convergence, 14(4), 471-478. DOI : 10.14400/JDC.2016.14.4-471.
  25. D. Rucker, R. Padwal, S. K. Li, C. Curioni., & D. C. Lau. (2007). Long term pharmacotherapy for obesity and overweight: updated meta-analysis. The British Medical Journal, 335(7631), 1194-1199. doi: https://doi.org/10.1136/bmj.39385.413113.25.
  26. M. O. Dietrich & T. L. Horvath. (2012). Limitations in anti-obesity drug development: the critical role of hunger-promoting neurons. Nature reviews Drug discovery, 11(9), 675-691. https://doi.org/10.1038/nrd3739