DOI QR코드

DOI QR Code

A Case Report of Korean Medicine Treatment of a Lung Cancer Patient with Chemotherapy-induced Peripheral Neuropathy

편평상피세포 폐암 환자의 항암화학요법에 의해 유발된 말초신경병증에 대한 한방치험 1례

  • Kim, Kyun Ha (National Clinical Research Center for Korean Medicine, Korean Medicine Hospital of Pusan National University) ;
  • Kim, Min-hwa (Dept. of Korean Internal Medicine, Korean Medicine Hospital of Pusan National University) ;
  • Heo, Gi-yoon (Dept. of Korean Internal Medicine, Korean Medicine Hospital of Pusan National University) ;
  • Lee, Chan (Dept. of Korean Internal Medicine, Korean Medicine Hospital of Pusan National University) ;
  • Cho, Im-hak (Dept. of Korean Internal Medicine, Korean Medicine Hospital of Pusan National University) ;
  • Kang, Hee-kyung (Dept. of Korean Internal Medicine, Korean Medicine Hospital of Pusan National University) ;
  • Kim, So-yeon (Dept. of Korean Internal Medicine, Korean Medicine Hospital of Pusan National University) ;
  • Park, Seong-ha (Dept. of Korean Internal Medicine, Korean Medicine Hospital of Pusan National University) ;
  • Yun, Young-ju (Dept. of Korean Internal Medicine, Korean Medicine Hospital of Pusan National University) ;
  • Lee, In (Dept. of Korean Internal Medicine, Korean Medicine Hospital of Pusan National University) ;
  • Han, Chang-woo (Dept. of Korean Internal Medicine, Korean Medicine Hospital of Pusan National University) ;
  • Hong, Jin-woo (Dept. of Korean Internal Medicine, Korean Medicine Hospital of Pusan National University) ;
  • Kwon, Jung-nam (Dept. of Korean Internal Medicine, Korean Medicine Hospital of Pusan National University) ;
  • Choi, Jun-Yong (National Clinical Research Center for Korean Medicine, Korean Medicine Hospital of Pusan National University)
  • 김균하 (부산대학교 한방병원 한의약임상연구센터) ;
  • 김민화 (부산대학교 한방병원 한방내과) ;
  • 허기윤 (부산대학교 한방병원 한방내과) ;
  • 이찬 (부산대학교 한방병원 한방내과) ;
  • 조임학 (부산대학교 한방병원 한방내과) ;
  • 강희경 (부산대학교 한방병원 한방내과) ;
  • 김소연 (부산대학교 한방병원 한방내과) ;
  • 박성하 (부산대학교 한방병원 한방내과) ;
  • 윤영주 (부산대학교 한방병원 한방내과) ;
  • 이인 (부산대학교 한방병원 한방내과) ;
  • 한창우 (부산대학교 한방병원 한방내과) ;
  • 홍진우 (부산대학교 한방병원 한방내과) ;
  • 권정남 (부산대학교 한방병원 한방내과) ;
  • 최준용 (부산대학교 한방병원 한의약임상연구센터)
  • Received : 2021.11.23
  • Accepted : 2021.12.17
  • Published : 2021.12.30

Abstract

The purpose of this study is to report the effect of Korean medicine on a squamous cell lung cancer patient with chemotherapy induction peripheral neuropathy (CIPN). A 61-year old male patient, who had received 4 cycles of chemotherapy after lung surgery from squamous cell lung cancer, was treated with acupuncture and herbal medicines, including Uchasingi-hwan and Samchilchoongcho-capsule, to control CIPN and dyspnea on exertion. The degree of pain was assessed by a numeric rating scale (NRS). After receiving acupuncture and herbal medicines, the NRS score for CIPN symptoms was reduced from 4 to 1 and the NRS score for dyspnea on exertion decreased from 3 to less than 1. Korean medicine could therefore be useful in reducing peripheral neuropathy occurring after chemotherapy and dyspnea after lobectomy.

Keywords

Acknowledgement

본 연구는 2020년도 부산대학교병원 임상연구비 지원으로 이루어졌습니다.

References

  1. Siegel RL, Miller KD, Fuchs HE, Jemal A. Cancer Statistics 2021. CA Cancer J Clin 2021;71(1):7-33. https://doi.org/10.3322/caac.21654
  2. Ding PN, Lord SJ, Gebski V, Links M, Bray V, Gralla RJ, et al. Risk of Treatment-Related Toxicities from EGFR Tyrosine Kinase Inhibitors: A Meta-analysis of Clinical Trials of Gefitinib, Erlotinib, and Afatinib in Advanced EGFR-Mutated Non-Small Cell Lung Cancer. J Thorac Oncol 2017;12(4):633-43. https://doi.org/10.1016/j.jtho.2016.11.2236
  3. Trivedi MS HD, Crew KD. Management of chemotherapy-induced peripheral neuropathy. Am J Hematol Oncol 2015;11(1):4-10.
  4. Seretny M, Currie GL, Sena ES, Ramnarine S, Grant R, MacLeod MR, et al. Incidence, prevalence, and predictors of chemotherapy-induced peripheral neuropathy: A systematic review and meta-analysis. Pain 2014;155(12):2461-70. https://doi.org/10.1016/j.pain.2014.09.020
  5. Brami C, Bao T, Deng G. Natural products and complementary therapies for chemotherapy-induced peripheral neuropathy: A systematic review. Crit Rev Oncol Hematol 2016;98:325-34. https://doi.org/10.1016/j.critrevonc.2015.11.014
  6. Loprinzi CL, Lacchetti C, Bleeker J, Cavaletti G, Chauhan C, Hertz DL, et al. Prevention and Management of Chemotherapy-Induced Peripheral Neuropathy in Survivors of Adult Cancers: ASCO Guideline Update. J Clin Oncol 2020;38(28):3325-48. https://doi.org/10.1200/jco.20.01399
  7. Hu LY MW, Wu GC, Wang YQ, Mao-Ying QL. Prevention and treatment for chemotherapy-induced peripheral nueropathy: Therapies based on CIPN mechanisms. Curr neropharmacol 2019;17(2):184-96. https://doi.org/10.2174/1570159X15666170915143217
  8. Derksen TM, Bours MJ, Mols F, Weijenberg MP. Lifestyle-Related Factors in the Self-Management of Chemotherapy-Induced Peripheral Neuropathy in Colorectal Cancer: A Systematic Review. Evid Based Complement Alternat Med 2017;2017:7916031.
  9. Kim MK, Kim BR, Choi YH, Han DJ, Jung CH, Shin SH, et al. A Case Study of a Patient Diagnosed as Diabetic Cystopathy with Dysuria. Korean J Orient Int Med 2008;29(4):1123-9.
  10. Shin H, Seo W, An SH, Won JH, Song BK. Case Report of Chemotherapy-Induced Peripheral Neuropathy Treated with Korean Medicine. Korean J Orient Int Med 2021;42(2):104-13. https://doi.org/10.22246/jikm.2021.42.2.104
  11. Lee SY, Ham YH, Ok ON, Kim EJ, Kwon IG, Hwang MS, et al. The Effects of Foot Reflexology on Peripheral Neuropathy, Symptom Distress, Anxiety and Depression in Cancer Patients Treated with Oxaliplatin. Asian Oncol Nurs 2012;12(4):305-13. https://doi.org/10.5388/aon.2012.12.4.305
  12. Tofthagen CS MS, Kip KE. Development and psychometric evaluation of the chemotherapy-induced peripheral neuropathy assessment tool. Cancer Nurs 2011;34(4):E10-20. https://doi.org/10.1097/NCC.0b013e31820251de
  13. Miltenburg NC, Boogerd W. Chemotherapy-induced neuropathy: A comprehensive survey. Cancer Treat Rev 2014;40(7):872-82. https://doi.org/10.1016/j.ctrv.2014.04.004
  14. Zhang S. Chemotherapy-induced peripheral neuropathy and rehabilitation: A review. Semin Oncol 2021;48(3):193-207. https://doi.org/10.1053/j.seminoncol.2021.09.004
  15. Schiller JH, Harrington D, Belani CP, Langer C, Sandler A, Krook J, et al. Comparison of four chemotherapy regimens for advanced non-small-cell lung cancer. N Engl J Med 2002;346(2):92-8. https://doi.org/10.1056/NEJMoa011954
  16. Litscher G, Wang L, Huber E, Nilsson G. Changed skin blood perfusion in the fingertip following acupuncture needle introduction as evaluated by laser Doppler perfusion imaging. Lasers Med Sci 2002;17(1):19-25. https://doi.org/10.1007/s10103-002-8262-9
  17. Kim EH, Yoon JH, Lee JY, Yoon SW. Efficacy of Acupuncture for Chemotherapy-Induced Peripheral Neuropathy: A Systematic Review and Meta-Analysis. Korean J Orient Int Med 2020;41(3):350-61. https://doi.org/10.22246/jikm.2020.41.3.350
  18. Je BS, Lim LC, Oh MS. The Literatural Study on Acupuncture and Moxibustion Therapy of Arthalgia Syndrome. Journal of Haehwa Medicine 2004;13(1):61-9.
  19. 황도윤. 방약합편. 서울: 도서출판 영림사; 2010, p. 681.
  20. Pearce A, Haas M, Viney R, Pearson SA, Haywood P, Brown C, et al. Incidence and severity of self-reported chemotherapy side effects in routine care: A prospective cohort study. PLoS One 2017;12(10):e0184360. https://doi.org/10.1371/journal.pone.0184360
  21. Kim JY, Bae K, Park SJ, Yoo HS. A Case of Patient with Recurring Non-Small Cell Lung Carcinoma Treated with Samchilchoongcho-Jung in Conjunction with Afatinib. Korean J Orient Int Med 2017;38(1):72-80.
  22. Ko MH, Myong JS, Park SJ, Jeon HJ, Lee YW, Cho CK, et al. A Case Report of Advanced Non-Small Cell Lung Cancer Patient Treated with Samchilchoongcho-Jung in Conjunction with Alectinib. J of Kor Traditional concology 2019;24(1):1-9.
  23. Cleeland C. The Brief Pain Inventory: A Users Guide. 2009. http://www.mdanderson.org/education-and-research/departments-programs-and-labs/departments-and-divisions/symptom-research/symptom-assessment-tools/BPI_UserGuide.pdf. Assessed 16 Dec, 2021.
  24. Cavaletti G, Frigeni B, Lanzani F, Piatti M, Rota S, Briani C, et al. The Total Neuropathy Score as an assessment tool for grading the course of chemotherapy-induced peripheral neurotoxicity: comparison with the National Cancer Institute-Common Toxicity Scale. J Peripher Nerv Syst 2007;12(3):210-5. https://doi.org/10.1111/j.1529-8027.2007.00141.x