대한한의학방제학회지 (Herbal Formula Science)

  • 제28권4호
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  • Pages.451-458
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  • 2020
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  • 1229-1218(pISSN)
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  • 2288-5641(eISSN)
대한한의학방제학회 (The Korean Medicine Society for the Herbal Formula Study)
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뇌졸중 후 발생한 뇌전증 환자에 우황청심원과 진간식풍탕가감방을 활용한 한의 치료 증례 보고 1례

A Case Report on Post-stroke Epilepsy Treated by Korean Medicine with Uwhangchungsimwon and Jingansikpungtang-gagambang

  • 박지원 (원광대학교 전주한방병원) ;
  • 김서희 (원광대학교 광주한방병원) ;
  • 이지은 (원광대학교 전주한방병원) ;
  • 임지성 (원광대학교 전주한방병원) ;
  • 유영수 (원광대학교 전주한방병원) ;
  • 조은희 (원광대학교 전주한방병원)
  • Park, Jiwon (Jeonju Korean Medicine Hospital of Wonkwang University) ;
  • Kim, Seo-Hee (Gwangju Korean Medicine Hospital of Wonkwang University) ;
  • Lee, Jieun (Jeonju Korean Medicine Hospital of Wonkwang University) ;
  • Im, Jisung (Jeonju Korean Medicine Hospital of Wonkwang University) ;
  • Lyu, Yeoung-Su (Jeonju Korean Medicine Hospital of Wonkwang University) ;
  • Jo, Eun-Heui (Jeonju Korean Medicine Hospital of Wonkwang University)
  • 투고 : 2020.11.06
  • 심사 : 2020.11.30
  • 발행 : 2020.11.30
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초록

뇌졸중 후 발생한 뇌전증 환자에서 항경련제와 함께 진간식풍탕가감방(鎭肝熄風湯加減方), 우황청심원(牛黃淸心元)을 위주로 하는 한의 치료를 병행하여 발작 억제 효과를 확인하였다.

Post-stroke epilepsy (PSE) slows the recovery process and reduces the quality of life of stroke survivors. Antiepileptic drugs are empirically prescribed to prevent PSE. However, the long-term use of antiepileptic drugs increases the risk of atherosclerosis, and up to 25% of patients have drug-resistant epilepsy. Herein, We report a patient with PSE who was treated with Korean medicine including Jingansikpungtang-gagambang and Uwhangchungsimwon. A 51-year-old patient had a past medical history of cerebral infarction that occurred in 2014. His first seizure occurred in January 2020 and he was diagnosed with PSE through a brain magnetic resonance imaging. The patient had a partial seizure with secondary generalization. After the initiation of taking Korean medicine, both the rate of progression to generalized seizures and the frequency of seizures was progressively and significantly reduced. This case report suggests that Korean medicine-based treatment may be safe and effective for PSE.

키워드

참고문헌

  1. Hauser WA, Annegers JF, Kurland LT. Incidence of epilepsy and unprovoked seizures in Rochester, Minnesota: 1935-1984. Epilepsia. 1993;34(3): 453-68. https://doi.org/10.1111/j.1528-1157.1993.tb02586.x
  2. Roivainen R, Haapaniemi E, Putaala J, Kaste M, Tatlisumak T. Young adult ischaemic stroke related acute symptomatic and late seizures: risk factors. Eur J Neurol. 2013;20(9): 1247-55. https://doi.org/10.1111/ene.12157
  3. Tanaka T, Yamagami H, Ihara M, Motoyama R, Fukuma K, Miyagi T, et al. Seizure Outcomes and Predictors of Recurrent Post-Stroke Seizure: A Retrospective Observational Cohort Study. PLoS One. 2015;10(8):e0136200. https://doi.org/10.1371/journal.pone.0136200
  4. Huang CW, Saposnik G, Fang J, Steven DA, Burneo JG. Influence of seizures on stroke outcomes: a large multicenter study. Neurology. 2014;82(9):768-76. https://doi.org/10.1212/WNL.0000000000000166
  5. Sander JW, Hart YM, Johnson AL, Shorvon SD. National General Practice Study of Epilepsy: newly diagnosed epileptic seizures in a general population. Lancet. 1990;336(8726): 1267-71. https://doi.org/10.1016/0140-6736(90)92959-L
  6. Arboix A, Comes E, Massons J, Garcia L, Oliveres M. Relevance of early seizures for in-hospital mortality in acute cerebrovascular disease. Neurology. 1996;47(6):1429-35. https://doi.org/10.1212/WNL.47.6.1429
  7. Tan TY, Lu CH, Chuang HY, Lin TK, Liou CW, Chang WN, et al. Long-term antiepileptic drug therapy contributes to the acceleration of atherosclerosis. Epilepsia. 2009;50(6):1579-86. https://doi.org/10.1111/j.1528-1167.2009.02024.x
  8. Ferlazzo E, Gasparini S, Beghi E, Sueri C, Russo E, Leo A, et al. Epilepsy in cerebrovascular diseases: Review of experimental and clinical data with meta-analysis of risk factors. Epilepsia. 2016;57(8):1205-14. https://doi.org/10.1111/epi.13448
  9. Lee JE, Bae HH, Han YJ, Lim DH, Hwang JH, Jeong IC, et al. A case report of patient with epileptic seizure. Korean Orient Int Med. 2005;26(2):453-458.
  10. Cho CH, Cho YS, Yoon JW, Lee SK. Case of 'Dianxian' patient induced by Eum Deficiency of Liver & Kidney who was considered as complex partial seizure treated by acupuncture. Korean Journal of Oriental Physiology & Pathology. 2007;21(1):328-332.
  11. Yi JH. A case report of the poststroke seizure. The Journal of Korea CHUNA Manual Medicine for Spine & Nerves. 2006;1(1): 27-33.
  12. Kim KS, Sung GK, Moon BS. An Experimental Study on the Antiepileptic Effects of Ukgansan. KIMS. 1998;19(1):57-72.
  13. Menon B, Shorvon SD. Ischaemic stroke in adults and epilepsy. Epilepsy Res. 2009;87(1):1-11. https://doi.org/10.1016/j.eplepsyres.2009.08.007
  14. Vezzani A, Friedman A, Dingledine RJ. The role of inflammation in epileptogenesis. Neuropharmacology. 2013;69:16-24. https://doi.org/10.1016/j.neuropharm.2012.04.004
  15. Pitkanen A, Roivainen R, Lukasiuk K. Development of epilepsy after ischaemic stroke. Lancet Neurol. 2016;15(2):185-197. https://doi.org/10.1016/S1474-4422(15)00248-3
  16. zhang xi chun. yi xue zhong zhong sen xi lu. shi jia zhuang shi, hebei science technology publishing company, China. 1985;113-116.
  17. Ryu HH, Lee SG, Lee KS. The Regulatory Effect of Zhengan Xifeng-tang on Proinflammatory Cytokine in Human Brain Astrocytes. Journal of Physiology & Pathology in Korean Medicine. 2004;18(2):490-495.
  18. Cho TS, Lee SM, Lee EB, Cho SI, Kim YK, Shin DH, et al. Pharmacological Actions of New Woohwangchungsimwon Pill on Cerebral Ischemia and Central Nervous System. Yakhak Hoeji. 1997;41(6):817-828.
  19. Choi JH, Jang M, Kim EJ, Kim H, Ye SK, Cho IH. Oriental Medicine Woohwangchungsimwon Attenuates Kainic Acid-Induced Seizures and Neuronal Cell Death in the Hippocampus. Rejuvenation Res. 2016;19(5):394-405. https://doi.org/10.1089/rej.2015.1779
  20. Lee WY, Jang SW, Lee JS, Kim YH, Kim HG, Han JM, et al. Uwhangchungsimwon, a traditional herbal medicine, protects brain against oxidative injury via modulation of hypothalamus-pituitary-adrenal (HPA) response in a chronic restraint mice model. J Ethnopharmacol. 2014;151(1):461-9. https://doi.org/10.1016/j.jep.2013.10.066