DOI QR코드

DOI QR Code

Ocular complications in patients with anti-adhesion barrier agent during arthroscopic shoulder surgery

견관절경 수술에서 사용된 유착방지제와 수술 후 안구 합병증의 연관성

  • Heo, Hyun Joo (Department of Anesthesiology and Pain Medicine, Presbyterian Medical Center) ;
  • Lee, Ji Hye (Department of Anesthesiology and Pain Medicine, Presbyterian Medical Center) ;
  • Kim, Yu Yil (Department of Anesthesiology and Pain Medicine, Presbyterian Medical Center) ;
  • Baek, Seung Min (Department of Anesthesiology and Pain Medicine, Presbyterian Medical Center) ;
  • Jung, Da Wa (Department of Anesthesiology and Pain Medicine, Presbyterian Medical Center)
  • 허현주 (예수병원 마취통증의학과) ;
  • 이지혜 (예수병원 마취통증의학과) ;
  • 김유일 (예수병원 마취통증의학과) ;
  • 백승민 (예수병원 마취통증의학과) ;
  • 정다와 (예수병원 마취통증의학과)
  • Received : 2020.08.24
  • Accepted : 2020.10.20
  • Published : 2020.10.28

Abstract

Background: Intraoperative and postoperative ocular complications are rare. We retrospectively investigated the abnormal ocular findings in patients who underwent arthroscopic shoulder surgery. Methods: The records were investigated of patients who underwent shoulder arthroscopic surgery at our hospital between January 2018 and March 2019. Ocular complications were confirmed by review of medical records. We performed logistic regression analysis to defined the main factors associated with ocular complications. Results: The overall prevalence of postoperative ocular complications was 8.5% (18/211). A significant association was found between anti-adhesion barrier agent and ocular complications (p=0.020). Conclusions: Anti-adhesion barrier agent used during surgery may be the cause of postoperative ocular complication.

배경; 수술 중, 후에 안과적 문제가 발생하는 경우는 매우 드물다. 이 연구는 견관절 수술 후 눈에 이상이 발견된 환자를 확인하고 그의 원인을 후향적으로 조사하였다. 방법; 2018년 1월에서 2019년 3월까지 본원에서 견관절경 수술을 받은 환자를 대상으로 후향적 연구방법을 통해 환자의 의무기록, 사용 약물들을 확인하였다. 로지스틱회귀분석을 통해 눈의 이상과 관련될 수 있는 여러 인자들을 가지고 연관성을 확인하였다. 결과; 8.5% (18/211)의 환자에서 눈의 이상이 발견되었고, 유착방지제와 안과적 합병증이 통계적 연관성을 보였다(p=0.020). 결론; 수술부위의 유착방지를 위해 사용되는 유착방지제에 젤라틴과 키토산 성분이 포함되어 알레르기 반응을 일으켜 안과적 합병증을 발생시킬 수 있을 것으로 생각된다.

Keywords

References

  1. P. G. Barash et al. (2017). Clinical anesthesia. 8th ed. Philadelphia : Wolters Kluwer.
  2. S. Roth, R. A. Thisted, J. P. Erickson, S. Black. & B. D. Schreider. (1996) Eye injuries after nonocular surgery. A study of 60,965 anesthetics from 1988 to 1992. Anesthesiology, 85(5), 1020-1027. https://doi.org/10.1097/00000542-199611000-00009
  3. K. L. Segal et al. (2014) Evaluation and treatment of perioperative corneal abrasions. Journal of Ophthalmology, 2014. DOI: 10.1155/2014/901901
  4. H. D. Yu, A. H. Chou, M. W. Yang & C. J. Chang. (2010). An analysis of perioperative eye injuries after nonocular surgery. Acta Anaesthesiologica Taiwanica, 48(3), 122-129. DOI:10.1016/S1875-4597(10)60043-4
  5. D. Pavan-Langston. (2008). Manual of Ocular Diagnosis and Therapy. 6th edition. Philadelphia: Lippincott Williams & Wilkins.
  6. A. M. Bodratti & P. Alexandridis. (2018). Formulation of poloxamers for drug delivery. Journal of Functional Biomaterials, 9(1), 11. DOI:10.3390/jfb9010011
  7. E. Russo & C. Villa. (2019). Poloxamer hydrogels for biomedical applications. Pharmaceutics, 11(12), 671. DOI:10.3390/pharmaceutics11120671
  8. T. K. Giri, A. Thakur, A. Alexander, H. Badwaik & D. K. Tripathi. (2012). Modified chitosan hydrogels as drug delivery and tissue engineering systems: present status and applications. Acta Pharmaceutica Sinica B, 2(5), 439-449. DOI:10.1016/j.apsb.2012.07.004
  9. J. Kim, S. Y. Cheon, D. I. Shin, C. M. Lee & K. Y. Lee. (2017). Adhesion barrier of methylcellulose based thermo-responsive sol-gel. Polymer(Korea), 41(2), 318-323. DOI:10.7317/pk.2017.41.2.318
  10. R. A. A. Muzzarelli. (2010). Chitins and chitosans as immunoadjuvants and non-allergenic drug carriers. Marine drugs, 8(2), 292-312. DOI:10.3390/md8020292
  11. C. A. Acevedo, P. Diaz-Calderon, D. Lopez & J. Enrione. (2015). Assessment of gelatin-chitosan interactions in films by a chemometrics approach. CyTA-Journal of Food, 13(2), 227-234. DOI:10.1080/19476337.2014.944570
  12. S. D. Ray. (2011). Potential aspects of chitosan as pharmaceutical excipient. Acta Pol. Pharm, 68(5), 619-622.
  13. S. Ahmed & S. Ikram. (2016). Chitosan based scaffolds and their application in wound healing. Achievements in the Life Sciences, 10(1), 27-37. DOI:10.1016/j.als.2016.04.001
  14. M. Sakaguchi & S. Inouye. (2000). Systemic allergic reactions to gelatin included in vaccines as a stabilizer. Japanese Journal of Infectious Diseases, 53(5), 189-195.
  15. M. Sakaguchi & S.Inouye. (2001). Anaphylaxis to gelatin-containing rectal suppositories. Journal of allergy and clinical immunology, 108(6), 1033-1034. DOI: 10.1067/mai.2001.119412