Journal of Oriental Neuropsychiatry (동의신경정신과학회지)

The Korean Society of Oriental Neuropsychiatry (대한한방신경정신과학회)
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Clinical Effect of Acupuncture Combined with Herbal Medicine in Treatment of PSD: A Systematic Review and Meta-Analysis

뇌졸중 후 우울증에 대한 침과 한약의 결합 치료 효과: 체계적 문헌 고찰 및 메타분석 연구

  • Sakong, Jong-Won (Department of Oriental Neuropsychiatry, College of Korean Medicine, Daegu Hanny University) ;
  • Lim, Su-Yeon (Department of Oriental Neuropsychiatry, Jaseng Hospital of Korean Medicine) ;
  • Kim, Sang-Ho (Department of Oriental Neuropsychiatry, College of Korean Medicine, Daegu Hanny University) ;
  • Chung, Dae-kyoo (Department of Oriental Neuropsychiatry, College of Korean Medicine, Daegu Hanny University)
  • 사공종원 (대구한의대학교 한의과대학 한방신경정신과교실) ;
  • 임수연 (자생한방병원 한방신경정신과) ;
  • 김상호 (대구한의대학교 한의과대학 한방신경정신과교실) ;
  • 정대규 (대구한의대학교 한의과대학 한방신경정신과교실)
  • Received : 2020.09.02
  • Accepted : 2020.09.11
  • Published : 2020.09.30
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Abstract

Objectives: The purpose of this study was to provide clinical evidence to support the use of acupuncture combined herbal medicine for post-stroke depression. Methods: Studies were identified by searching Pubmed, EMBASE, Cochrane Library, NDSL, RISS, KMbase, KISS, and CNKI. Randomized controlled trials that verified effects of the acupuncture combined with the herbal medicine for PSD were included in this study. Literature searches of English, Chinese, and Korean databases were performed. Two authors independently extracted the data and assembled the study quality. Results: Of 698 RCTs screened, 17 RCTs were selected. Most of the studies had unclear risk of bias. Among the 17 RCTs, 10 were meta-analyzed. As for the outcome measurement, the effective rate and the HAMD were most commonly used. The meta-analysis of the studies revealed that the PSD cure effective rate in the acupuncture combined with herbal medicine group was higher than that in the Western medicine group (RR: 1.23, 95% CI: 1.14 to 1.33, p<0.00001, I2=0%). Also, the HAMD in the acupuncture combined with herbal medicine group was significantly different compared to the Western medicine group (MD -5.54, 95% CI -9.80 to -1.29, p=0.01, I2=99%). The quality of the selected RCTs was low. Conclusions: Acupuncture combined with herbal medicine is effective for treating post-stroke depression. However, It is worth noting that the included studies were of relatively poor quality. The sample sizes were also small. Based on the findings of this study, further investigations into the diagnosis and treatment of PSD are warranted.

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