The Journal of Korean Medicine (대한한의학회지)

The Society of Korean Medicine (대한한의학회)
권호 표지
DOI QR코드

DOI QR Code

Clinical Characteristics of Pain in Patients with Parkinson's Disease Who Have Visited a Korean Medical Hospital : A Retrospective Chart Review

한방병원에 내원한 파킨슨병 환자의 통증의 임상적 특성에 관한 후향적 의무기록 분석 연구

  • Jeong, Hye-Seon (Stroke and Neurological Disorders Center, Kyung Hee University Korean Medicine Hospital at Gangdong) ;
  • Kim, Ha-Ri (Department of Cardiology and Neurology of Clinical Korean Medicine, Graduate School, Kyung Hee University) ;
  • Kim, Seo-Young (Department of Cardiology and Neurology of Clinical Korean Medicine, Graduate School, Kyung Hee University) ;
  • Yim, Tae-Bin (Department of Cardiology and Neurology of Clinical Korean Medicine, Graduate School, Kyung Hee University) ;
  • Jin, Chul (Department of Cardiology and Neurology of Clinical Korean Medicine, Graduate School, Kyung Hee University) ;
  • Kwon, Seung-Won (Department of Cardiology and Neurology of Clinical Korean Medicine, Graduate School, Kyung Hee University) ;
  • Cho, Seung-Yeon (Stroke and Neurological Disorders Center, Kyung Hee University Korean Medicine Hospital at Gangdong) ;
  • Jung, Woo-Sang (Department of Cardiology and Neurology of Clinical Korean Medicine, Graduate School, Kyung Hee University) ;
  • Moon, Sang-Kwan (Department of Cardiology and Neurology of Clinical Korean Medicine, Graduate School, Kyung Hee University) ;
  • Park, Jung-Mi (Stroke and Neurological Disorders Center, Kyung Hee University Korean Medicine Hospital at Gangdong) ;
  • Ko, Chang-Nam (Stroke and Neurological Disorders Center, Kyung Hee University Korean Medicine Hospital at Gangdong) ;
  • Park, Seong-Uk (Stroke and Neurological Disorders Center, Kyung Hee University Korean Medicine Hospital at Gangdong)
  • 정혜선 (강동경희대학교한방병원 뇌신경센터 한방내과) ;
  • 김하리 (경희대학교 대학원 한방순환신경내과학교실) ;
  • 김서영 (경희대학교 대학원 한방순환신경내과학교실) ;
  • 임태빈 (경희대학교 대학원 한방순환신경내과학교실) ;
  • 진철 (경희대학교 대학원 한방순환신경내과학교실) ;
  • 권승원 (경희대학교 대학원 한방순환신경내과학교실) ;
  • 조승연 (강동경희대학교한방병원 뇌신경센터 한방내과) ;
  • 정우상 (경희대학교 대학원 한방순환신경내과학교실) ;
  • 문상관 (경희대학교 대학원 한방순환신경내과학교실) ;
  • 박정미 (강동경희대학교한방병원 뇌신경센터 한방내과) ;
  • 고창남 (강동경희대학교한방병원 뇌신경센터 한방내과) ;
  • 박성욱 (강동경희대학교한방병원 뇌신경센터 한방내과)
  • Received : 2020.04.07
  • Accepted : 2020.05.21
  • Published : 2020.06.01
Download PDF
⟨ Previous Next ⟩

Abstract

Objectives: To investigate the prevalence of pain, clinical characteristics of pain, association between clinical features and pain of patients with Parkinson's Disease(PD). Methods: We undertook a retrospective review of the medical records of patients diagnosed with PD between 2012 and 2019 at Kyung Hee University Korean Medicine Hospital at Gangdong in South Korea. Results: A total of 172 PD patients met entry criteria and 147 out of 172 patients(85.5%) reported pain. In comparison with general population, PD patients has high prevalence of pain. Female PD patients more frequently reported pain than male (P=0.03). 102 out of 147patients(69.3) complained of musculoskeletal pain, and musculoskeletal pain show significant difference depending on the PD motor subtypes (P=0.039). Pain was mainly locatedin the leg (57.8%) in all PD motor subtypes. Tremor-dominant PD more frequently felt pain in upper limb than postural instability-gait difficulty dominant(PIGD) PD, but it was not statistically significant. Conclusions: These findings showed high prevalence of pain in PD patients, the correlation between female and pain, and the relationship between PD motor subtype and pain type. Our study can contribute to the clinical approach based on a more in-depth understanding of PD patients with pain.

Keywords

References

  1. Association of Korean Medicine Professors for Cardiovascular and Neurologic Medicine. Cardiovascular and Neurological Medicine in Korean Medicine 3.Seoul: WOORI Medical Books. 2016:113-114.
  2. Gelb DJ, Oliver E, Gilman S. Diagnostic Criteria for Parkinson Disease. JAMA Neurol. 1999;56(1):33-39.
  3. Buhmann C, Wrobel N, Grashorn W, et al. Pain in Parkinson disease: a cross-sectional survey of its prevalence, specifics, and therapy. J Neurol. 2017;264(4):758-769. https://doi.org/10.1007/s00415-017-8426-y
  4. Broen MPG, Braaksma MM, Patijn J, Weber WEJ. Prevalence of pain in Parkinson's disease: a systematic review using the modified QUADAS tool. Mov Disord. 2012;27(4):480-484. https://doi.org/10.1002/mds.24054
  5. Zhang LM, Chen YQ, Li WJ, Sun W, Huang Y, Zou HQ. Association between mutations of SCN9A gene and pain related to Parkinsonism. Chinese J Med Genet. 2013;30(1):17-20.
  6. Greenbaum L, Tegeder I, Barhum Y, Melamed E, Roditi Y, Djaldetti R. Contribution of genetic variants to pain susceptibility in Parkinson disease. Eur J Pain. 2012;16(9):1243-1250. https://doi.org/10.1002/j.1532-2149.2012.00134.x
  7. Rukavina K, Leta V, Sportelli C, et al. Pain in Parkinson's disease: New concepts in pathogenesis and treatment. Curr Opin Neurol. 2019;32(4):579-588. https://doi.org/10.1097/WCO.0000000000000711
  8. Trenkwalder C, Chaudhuri KR, Martinez MP, et al. Prolonged-release oxycodone-naloxone for treatment of severe pain in patients with Parkinson's disease (PANDA): A double-blind, randomised, placebo-controlled trial. Lancet Neurol. 2015;14(12):1161-1170. https://doi.org/10.1016/S1474-4422(15)00243-4
  9. Valkovic P, Minar M, Singliarova H, et al. Pain in Parkinson's disease: A cross-sectional study of its prevalence, types, and relationship to depression and quality of life. PLoS One. 2015;10(8).
  10. Jankovic J, McDermott M, Carter J, et al. Variable expression of Parkinson's disease: A base-line analysis of the DAT ATOP cohort. Neurology. 1990;40(10):1529-1529. https://doi.org/10.1212/WNL.40.10.1529
  11. Pont-Sunyer C, Hotter A, Gaig C, et al. The onset of nonmotor symptoms in parkinson's disease (the onset pd study). Mov Disord. 2015;30(2):229-237. https://doi.org/10.1002/mds.26077
  12. Chaudhuri KR, Rizos A, Trenkwalder C, et al. King's Parkinson's disease pain scale, the first scale for pain in PD: An international validation. Mov Disord. 2015;30(12):1623-1631. https://doi.org/10.1002/mds.26270
  13. Ministry of Employment and Labor. 2012 Korean Longitudinal Study of Ageing(KLoSA). Korea Employment Information Service. 2013.
  14. Duvoisin RC, Marsden CD. Note on the scoliosis of Parkinsonism. J Neurol Neurosurg Psychiatry. 1975;38(8):787-793. https://doi.org/10.1136/jnnp.38.8.787
  15. Djaldetti R, Shifrin A, Rogowski Z, Sprecher E, Melamed E, Yarnitsky D. Quantitative measurement of pain sensation in patients with Parkinson disease. Neurology. 2004;62(12):2171-2175. https://doi.org/10.1212/01.WNL.0000130455.38550.9D
  16. Gerdelat-Mas A, Simonetta-Moreau M, Thalamas C, et al. Levodopa raises objective pain threshold in Parkinson's disease: A RIII reflex study. J Neurol Neurosurg Psychiatry. 2007;78(10):1140-1142. https://doi.org/10.1136/jnnp.2007.120212
  17. Gandolfi M, Geroin C, Antonini A, Smania N, Tinazzi M. Understanding and Treating Pain Syndromes in Parkinson's Disease. In: International Review of Neurobiology. Vol 134. Academic Press Inc.; 2017:827-858.
  18. Jarcho JM, Mayer EA, Jiang ZK, Feier NA, London ED. Pain, affective symptoms, and cognitive deficits in patients with cerebral dopamine dysfunction. Pain. 2012;153(4):744-754. https://doi.org/10.1016/j.pain.2012.01.002
  19. Hanagasi HA, Akat S, Gurvit H, Yazici J, Emre M. Pain is common in Parkinson's disease. Clin Neurol Neurosurg. 2011;113(1):11-13. https://doi.org/10.1016/j.clineuro.2010.07.024
  20. Tinazzi M, Del Vesco C, Fincati E, et al. Pain and motor complications in Parkinson's disease. J Neurol Neurosurg Psychiatry. 2006;77(7):822-825. https://doi.org/10.1136/jnnp.2005.079053
  21. Muller T, Muhlack S, Woitalla D. Pain perception, pain drug therapy and health status in patients with Parkinson's disease. Neuroepidemiology. 2011;37(3-4):183-187. https://doi.org/10.1159/000331911
  22. Scott B, Borgman A, Engler H, Johnels B, Aquilonius SM. Gender differences in Parkinson's disease symptom profile. Acta Neurol Scand. 2000;102(1):37-43. https://doi.org/10.1034/j.1600-0404.2000.102001037.x
  23. Han CS, Pae CU. Pain and Depression: A Neurobiological Perspective of Their Relationship. Psychiatry Investig. 2015;12(1):1-8. https://doi.org/10.4306/pi.2015.12.1.1
  24. Beiske AG, Loge JH, Ronningen A, Svensson E. Pain in Parkinson's disease: Prevalence and characteristics. Pain. 2009;141(1-2):173-177. https://doi.org/10.1016/j.pain.2008.12.004
  25. Jankovic J, McDermott M, Carter J, et al. Variable expression of Parkinson's disease: A base-line analysis of the DAT ATOP cohort. Neurology. 1990;40(10):1529-1529. https://doi.org/10.1212/WNL.40.10.1529
  26. Jankovic J, Kapadia AS. Functional decline in Parkinson disease. Arch Neurol. 2001;58(10):1611-1615. https://doi.org/10.1001/archneur.58.10.1611
  27. Stebbins GT, Goetz CG, Burn DJ, Jankovic J, Khoo TK, Tilley BC. How to identify tremor dominant and postural instability/gait difficulty groups with the movement disorder society unified Parkinson's disease rating scale: comparison with the unified Parkinson's disease rating scale. Mov Disord. 2013;28(5):668-670. https://doi.org/10.1002/mds.25383
  28. Eisinger RS, Hess CW, Martinez-Ramirez D, et al. Motor subtype changes in early Parkinson's disease. Park Relat Disord. 2017;43:67-72. https://doi.org/10.1016/j.parkreldis.2017.07.018
  29. Kotagal V. Is PIGD a legitimate motor subtype in Parkinson disease? Ann Clin Transl Neurol. 2016;3(6):473-477. https://doi.org/10.1002/acn3.312
  30. Zella MAS, May C, Muller T, et al. Landscape of pain in Parkinson's disease: impact of gender differences. Neurol Res. 2019;41(1):87-97. https://doi.org/10.1080/01616412.2018.1531208

Cited by

  1. 파킨슨병 환자의 통증에 대한 한의치료의 효과 : 후향적 연구 vol.41, pp.6, 2020, https://doi.org/10.22246/jikm.2020.41.6.947