Journal of the Korean Society of Radiology (대한영상의학회지)

The Korean Society of Radiology (대한영상의학회)
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Microbleeds in the Corpus Callosum in Anoxic Brain Injury

저산소 뇌 손상에서의 뇌량 미세출혈

  • Chang Su Kim (Department of Radiology, College of Medicine, Hanyang University Guri Hospital) ;
  • Dong Woo Park (Department of Radiology, College of Medicine, Hanyang University Guri Hospital) ;
  • Tae Yoon Kim (Department of Radiology, College of Medicine, Hanyang University Guri Hospital) ;
  • Young-Jun Lee (Department of Radiology, College of Medicine, Hanyang University Hospital) ;
  • Ji Young Lee (Department of Radiology, College of Medicine, Hanyang University Hospital)
  • 김창수 (한양대학교 의과대학 구리병원 영상의학과) ;
  • 박동우 (한양대학교 의과대학 구리병원 영상의학과) ;
  • 김태윤 (한양대학교 의과대학 구리병원 영상의학과) ;
  • 이영준 (한양대학교 의과대학 한양대학교병원 영상의학과) ;
  • 이지영 (한양대학교 의과대학 한양대학교병원 영상의학과)
  • Received : 2019.06.07
  • Accepted : 2019.10.18
  • Published : 2020.09.01
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Abstract

Purpose This study was performed to evaluate the relationship between callosal microbleeds and anoxic brain injury. Materials and Methods Twenty-seven patients with anoxic brain injuries were analyzed and retrospectively compared to the control group of patients without a history of anoxic brain injury using Fisher's exact test regarding comorbidities and cerebral microbleeds. The patient group was subdivided according to the presence of callosal microbleeds. Fisher's exact test was used to compare the presence of typical MRI findings of anoxic brain injury, use of cardiopulmonary resuscitation, and prognosis. The Mann-Whitney U test was used to compare the interval between the occurrence of anoxic brain injury to MRI acquisition. Results The prevalence of cerebral microbleeds in the patient group was 29.6%, which was significantly higher than that in the control group at 3.7% (p = 0.012). All cerebral microbleeds in the patient group were in the corpus callosum. Compared with the callosal microbleed-absent group, the callosal microbleed-present group showed a tendency of good prognosis (6/8 vs. 11/19), fewer typical MRI findings of anoxic brain injury (2/8 vs. 10/19), and more cardiopulmonary resuscitation (6/8 vs. 12/19), although these differences did not reach statistical significance (p = 0.35, p = 0.19, and p = 0.45, respectively). Conclusion Callosal microbleeds may be an adjunctive MRI marker for anoxic brain injury.

목적 뇌량 미세출혈이 저산소 뇌 손상과 상관관계가 있는지 알아보고자 하였다. 대상과 방법 임상적으로 진단된 27명의 저산소 뇌 손상 환자군을 대상으로 후향적으로 연구를 진행하였다. 나이와 성별을 매칭한 대조군과 Fisher's exact test로 동반 질환, 뇌 미세출혈 유무를 비교하였다. 환자군은 뇌량 미세출혈의 유무로 나누어 비교하였다. Fisher's exact test로 두 그룹 간의 저산소 뇌 손상의 전형적인 자기공명영상 특징 유무, 심폐소생술 유무, 예후 정도를 비교하였고, Mann-Whitney U test로 저산소 뇌 손상 사건 발생 후 자기공명영상 획득까지의 시간 간격을 비교하였다. 결과 환자군에서 뇌 미세출혈은 29.6%에서 보였으며, 이는 대조군의 3.7%보다 통계적으로 유의하게 높았다(p = 0.012). 환자군에서의 모든 뇌 미세출혈은 뇌량에 국한됐다. 비뇌량 미세출혈군과 비교하여, 뇌량 미세출혈군은 좋은 예후를 보이는 경우가 많았고(6/8 vs. 11/19), 저산소 뇌 손상의 전형적인 자기공명영상 특징을 작은 비율에서 보이며(2/8 vs. 10/19), 심폐소생술이 많은 비율에서 시행됐으나(6/8 vs. 12/19) 통계적 유의성을 보이진 못하였다(p = 0.35, p = 0.19, p = 0.45, respectively). 결론 뇌량 미세출혈은 저산소 뇌 손상을 시사하는 부수적인 자기공명영상 특징이 될 수 있겠다.

Keywords

Acknowledgement

The authors would like to thank research professor Eunwoo Nam for grateful statistical consultation.

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