대한조현병학회지 (Korean Journal of Schizophrenia Research)

  • 제23권2호
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  • Pages.51-57
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  • 2020
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  • 2287-6995(pISSN)
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  • 2671-7786(eISSN)
대한조현병학회 (Korean Society for Schizophrenia Research)
권호 표지
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치료 위저항성 조현병: 치료 비순응을 중심으로

Pseudo-Resistant Schizophrenia: Non-Adherence to Treatment

  • 김혜림 (경북대학교 의과대학 정신건강의학교실) ;
  • 이승재 (경북대학교 의과대학 정신건강의학교실)
  • Kim, Hyerim (Department of Psychiatry, School of Medicine, Kyungpook National University) ;
  • Lee, Seung Jae (Department of Psychiatry, School of Medicine, Kyungpook National University)
  • 투고 : 2020.10.09
  • 심사 : 2020.10.12
  • 발행 : 2020.10.30
⟨ 이전 논문 다음 논문 ⟩

초록

Treatment-resistant schizophrenia (TRS) has been defined as the persistence of positive symptoms despite two or more trials of antipsychotic medication of adequate dose and duration. TRS is a serious clinical problem and occurs in approximately 30% of patients with schizophrenia. It is important that patients who do not adequately respond to antipsychotics be reevaluated to exclude or address causes other than non-responsiveness to medication, that is, the possibility of pseudo-resistance. In particular, non-adherence to oral antipsychotic treatment should be monitored to rule out pseudo-resistant cases of TRS. Moreover, patients with TRS who take their medication as required may have subtherapeutic antipsychotic plasma levels, secondary to pharmacokinetic factors. In this paper, we review the concept and exclusion of pseudo-resistance, especially owing to non-adherence or pharmacokinetic factors, and present methods to enhance drug adherence.

키워드

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