대한방사선기술학회지:방사선기술과학 (Journal of radiological science and technology)

  • 제43권2호
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  • Pages.97-103
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  • 2020
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  • 2288-3509(pISSN)
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  • 2384-1168(eISSN)
대한방사선과학회 (Korean Society of Radiological Science)
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핵의학과에서 99mTc를 이용한 방사성의약품의 투여율 측정 비교

Comparison of the Measurement of the Injection Rate of Radioactive Drugs Using 99mTc in Nuclear Medicine

  • 손상준 (대구파티마병원 핵의학과) ;
  • 박정규 (대구보건대학교 방사선과) ;
  • 정동경 (대구보건대학교 방사선과) ;
  • 박명환 (대구보건대학교 방사선과)
  • Son, Sang-Joon (Department of Nuclear Medicine, Daegu Patima Hospital) ;
  • Park, Jeong-Kyu (Department of Radiological Technology, Daegu Health College) ;
  • Jung, Dong-Kyung (Department of Radiological Technology, Daegu Health College) ;
  • Park, Myeong-Hwan (Department of Radiological Technology, Daegu Health College)
  • 투고 : 2020.03.02
  • 심사 : 2020.04.22
  • 발행 : 2020.04.30
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초록

This study was conducted by SPECT test at the Department of Nuclear Medicine at Daegu P Hospital from June 1 to October 31, 2019. A 3-way injection material was mounted among inpatients, and a syringe that was administered with radiopharmaceuticals using a 99mTc labeled compound was secured. We tried to find a way to calculate the dose rate of each radiopharmaceutical and increase the dose rate. As a result of measuring the radioactivity of radio-pharmaceuticals using 99mTc, the average dose rate of 60 syringes of all 6 radiopharmaceuticals was 93.26±7.34%, and the average dose rate of 99mTc-DMSA was 77.72%, 15.54% lower than the total. As a way to increase the dosing rate, the average dose rate diluted twice with the remaining amount of syringe after administration using normal saline increased to 95.37±6.99%, and the average dose rate diluted three times increased to 96.32±6.86%. The corresponding sample t-test to compare the pre- and post-dose rates at 1 dilution and 2 and 3 dilutions. As a result of the dilution and 2 dilutions, the probability of significance was 0.013, which was significantly higher than the dilution(p<0.05). The probability of significance for dilution 1 and dilution 3 was 0.016, which was significantly higher than in one dilution(p<0.05). The sum of the average dose rate using the experimental 3-way line was the highest with 98.85±1.42% of 99mTc, 99mTc-ECD 98.82±1.26%, 99mTc-Mebrofenin 98.82 ± 1.16%, 99mTc-HDP 98.74 ± 1.91%, 99mTc -MIBI was 98.69 ± 1.48%, and 99mTc-DMSA was the lowest with 86.47 ± 4.74%. When the number of dilutions was 5 times using 0.5 cc of normal saline and when the number of dilutions was 5 times using 1 cc of normal saline, when the number of dilutions was 5 times using 0.5 cc of normal saline and 1 cc of nomal saline When the number of dilutions was 5 times and the syringe volume was 0.5 cc, there was a statistically significant difference (p<0.05). There was a statistically significant difference when the number of dilutions was 5 times using 1 cc of nomal saline and the number of dilutions was 5 times using 1 cc of normal saline, and the syringe volume was 0.5 cc (p<0.05).

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참고문헌

  1. Chung JK, Lee MC. Nuclear Medicine. Seoul: Korea Medical Book publisher; 2008.
  2. Kim GJ, Bae SH, Kim KJ, Oh HK. Effect of Gamma Energy of Positron Emission Radionuclide on X-Ray CT Image. Journal of the Korea Academia-Industrial cooperation Society. 2011;12(10):4418-24. https://doi.org/10.5762/KAIS.2011.12.10.4418
  3. Seon CR, Gil JW. Study on Development of Patient Effective Dose Calculation Program of Nuclear Medicine Examination. Journal of the Korea Academia-Industrial cooperation Society. 2017;18(3):657-65. https://doi.org/10.5762/KAIS.2017.18.3.657
  4. Choi SY, Go Sj, Kang SS, Kim CS, Kim JH. Automated Functional Morphology Measurement Using Cardiac SPECT Images. Journal of Radiological Science and Technology. 2012:35(2):133-9.
  5. Choi DC, Kim YS, Cho KM, Kim HJ, Seo HG. Consideration of a bacteria contamination management in the dispensation of 99mTc radiopharmaceutical. Nuclear Medicine and Technology Society. 2018;22(2):84-7.
  6. James RB, Clemens D, Brit F, Brendan M, Geraldine OR, Helen R, et al. The Radiopharmacy A technologist's Guide. Vienna: European Association of Nuclear Medicine; 2008.
  7. https://blog.naver.com/qcci?Redirect=Log&logNo=140006256548
  8. Kim JH, Choi SY, Go Sj, Kang SS, Kim CS. Automated Functional Morphology Measurement Using Cardiac SPECT Images. Journal of Radiological Science and Technology. 2012;35(2):133-9.
  9. Pandey AK, Sharma SK, Sharma P, Gupta P, Kumar P. Development of a radiopharmaceutical dose calculator for pediatric patients undergoing diagnostic nuclear medicine studies. Indian J Nucl Med. 2013;28(2):75-8. https://doi.org/10.4103/0972-3919.118230
  10. Treves ST. Pediatric Nuclear Medicine. 2nd ed. New York: Springer-Verlag; 1995.
  11. Pandey AK, Sharma SK, Sharma P, Gupta P, Kumar P, Development of a radiopharmaceutical dose calculator for pediatric patients undergoing diagnostic nuclear medicine studies. Indian J Nucl Med. 2013;28(2):75-78. https://doi.org/10.4103/0972-3919.118230
  12. Treves ST. Pediatric Nuclear Medicine. 2nd ed. New York: Springer-Verlag; 1995.
  13. Galbraith W, Chen X, Talley K, Grantham V. Assessment of $^{99m}Tc$-succimer residual activity using inert nonreactive syringes. Journal of Nuclear Medicine Technology. 2015;43(1):61-3. https://doi.org/10.2967/jnmt.114.147983
  14. Bauwens M. Retention of $^{99m}Tc$-DMSA(III) and $^{99m}Tc$-nanocolloid in different syringes affects imaging quality. Nuclear Medicine Communications. 2014;35(4):433-7. https://doi.org/10.1097/mnm.0000000000000073
  15. Go CS. Nuclear medicine. 4rd ed. Seoul: Korea medicine; 2013.
  16. Gil JW. Comparing of the Administered Activities and the Effective Dose of the Various Pediatric Dose Formulas of Nuclear Medicine. Journal of the Korean Society for Convergence. 2017;8(8):147-54.