Journal of Microbiology and Biotechnology

The Korean Society for Microbiology and Biotechnology (한국미생물·생명공학회)
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Antifungal Activity of Silver Salts of Keggin-Type Heteropolyacids Against Sporothrix spp.

  • Mathias, Luciana Da Silva (Laboratorio de Sanidade Animal, Hospital Veterinario, Centro de Ciencias e Tecnologias Agropecuarias, Universidade Estadual do Norte Fluminense Darcy Ribeiro) ;
  • Almeida, Joao Carlos De Aquino (Laboratorio de Fisiologia e Bioquimica de Microrganismos, Centro de Biociencias e Biotecnologia, Universidade Estadual do Norte Fluminense Darcy Ribeiro) ;
  • Passoni, Luis Cesar (Laboratorio de Ciencias Quimicas, Centro de Ciencias e Tecnologias, Universidade Estadual do Norte Fluminense Darcy Ribeiro) ;
  • Gossani, Cristiani Miranda David (Laboratorio de Sanidade Animal, Hospital Veterinario, Centro de Ciencias e Tecnologias Agropecuarias, Universidade Estadual do Norte Fluminense Darcy Ribeiro) ;
  • Taveira, Gabriel Bonan (Laboratorio de Fisiologia e Bioquimica de Microrganismos, Centro de Biociencias e Biotecnologia, Universidade Estadual do Norte Fluminense Darcy Ribeiro) ;
  • Gomes, Valdirene Moreira (Laboratorio de Fisiologia e Bioquimica de Microrganismos, Centro de Biociencias e Biotecnologia, Universidade Estadual do Norte Fluminense Darcy Ribeiro) ;
  • Vieira-Da-Motta, Olney (Laboratorio de Sanidade Animal, Hospital Veterinario, Centro de Ciencias e Tecnologias Agropecuarias, Universidade Estadual do Norte Fluminense Darcy Ribeiro)
  • Received : 2019.07.26
  • Accepted : 2019.12.24
  • Published : 2020.04.28
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Abstract

Sporotrichosis is a chronic and subacute mycosis causing epidemiological outbreaks involving sick cats and humans in southeastern Brazil. The systemic disease prevails in cats and in humans, with the symptoms restricted to the skin of immunocompetent individuals. Under these conditions, the prolonged treatment of animals and cases of recurrence justify the discovery of new treatments for sporotrichosis. This work addresses the antifungal activity of silver salts of Keggin-type heteropolyacid salts (Ag-HPA salts) such as Ag3[PW12O40], Ag6[SiW10V2O40], Ag4[SiW12O40] and Ag3[PMo12O40] and interactions with the antifungal drugs itraconazole (ITC), terbinafine (TBF) and amphotericin B (AMB) on the yeast and mycelia forms of Sporothrix spp. Sporothrix spp. yeast cells were susceptible to Ag-HPA salts at minimum inhibitory concentration (MIC) values ranging from 8 to 128 ㎍/ml. Interactions between Ag3[PW12O40] and Ag3[PMo12O40] with itraconazole and amphotericin B resulted in higher antifungal activity with a reduction in growth and melanization. Treated cells showed changes in cell membrane integrity, vacuolization, cytoplasm disorder, and membrane detachment. Promising antifungal activity for treating sporotrichosis was observed for the Ag-HPA salts Ag3[PMo12O40] and Ag3[PW12O40], which have a low cost, high yield and activity at low concentrations. However, further evaluation of in vivo tests is still required.

Keywords

References

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