Natural Product Sciences

The Korean Society of Pharmacognosy (한국생약학회)
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Calyxaprenols A-D, New Merohexaprenoid Metabolites from the Marine Sponge Calyx sp.

  • Kim, Chang-Kwon (Molecular Targets Program, Center for Cancer Research, National Cancer Institute) ;
  • Gustafson, Kirk R. (Molecular Targets Program, Center for Cancer Research, National Cancer Institute)
  • Received : 2020.09.19
  • Accepted : 2020.11.26
  • Published : 2020.12.31
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Abstract

Four new merohexapenoids named calyxaprenols A-D (1 - 4), together with the known compound haliclotriol A (5), have been isolated from the marine sponge Calyx sp. which was collected from the southwest islands of Palau. Based on comprehensive spectroscopic analyses, calyxaprenols A (1) and B (2) were determined to be pentacyclic hexaprenoids that are appended to a glycolic acid-substituted phenol moiety, whereas calyxaprenols C (3) and D (4) possess a tricyclic hexaprenoid skeleton joined to a hydroquinone ring. Identification of new merohexaprenoids from a Calyx sponge expands the known taxonomic distribution of this sparsely distributed class of marine metabolites and increases the chemical diversity described for this genus of marine sponge.

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References

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