Natural Product Sciences

The Korean Society of Pharmacognosy (한국생약학회)
권호 표지
DOI QR코드

DOI QR Code

A New Cytotoxic Compound from Methanol Extract of Koordersiodendron pinnatum Merr. Leaves

  • Fajriah, Sofa (Research Center for Chemistry, Indonesian Institute of Sciences, Kawasan PUSPIPTEK) ;
  • Megawati, Megawati (Research Center for Chemistry, Indonesian Institute of Sciences, Kawasan PUSPIPTEK) ;
  • Darmawan, Akhmad (Research Center for Chemistry, Indonesian Institute of Sciences, Kawasan PUSPIPTEK) ;
  • Lotulung, Puspa Dewi N. (Research Center for Chemistry, Indonesian Institute of Sciences, Kawasan PUSPIPTEK) ;
  • Salahuddin, Salahuddin (Research Center for Chemistry, Indonesian Institute of Sciences, Kawasan PUSPIPTEK) ;
  • Hanafi, Muhammad (Research Center for Chemistry, Indonesian Institute of Sciences, Kawasan PUSPIPTEK)
  • Received : 2020.04.12
  • Accepted : 2020.10.15
  • Published : 2020.12.31
Download PDF
⟨ Previous Next ⟩

Abstract

Chemical investigation of the methanol extract of Koordersiodendron pinnatum Merr. leaves resulted a new naphthalene derivative, (Z)-4-(tetradec-3-enyl)naphthalene-1,2,7-triol (1), together with three known compounds, ��-sitosterol (2), 20-epibryonolic acid (3), and scopoletin (4). The structure of the new compound was elucidated based on spectroscopic evidence. The isolated compounds (1-4) were tested their cytotoxic activities against the P-388 murine leukemia cell line and compound 1 has highest activity with IC50 1.94 μM.

Keywords

References

  1. Boer, E.; Hildebrand, J. W.; Alonzo, D. S.; Fundter, J. M. In Plant Resources of South-East Asia No 5(2); Lemmens, R. H. M. J.; Soerianegara, I.; Wong, W. C. Ed; Backhuys Publishers; Leiden, 1995, pp 277-281.
  2. Banjarnahor, S. D. S.; Dewijanti, I. D.; Angelina, M.; Fajriah, S. J. Trop. Life Science 2016, 6,190-195. https://doi.org/10.11594/jtls.06.03.10
  3. Praptiwi, H. M. Majalah Farmasi Indonesia 2004, 15, 151-157.
  4. Megawati; Fajriah, S.; Hanafi, M.; Lotulung, P. D. N.; Darmawan, A.; Salahuddin. In Proceedings of International Conference on Drug Development of Natural Resources; Wahyuningsih, I.; Widyaningsih, W.; Sulistyani, M.; Utami, D. Ed; Faculty of Pharmacy Ahmad Dahlan University; Yogyakarta, 2012, pp. 255-260.
  5. Sahidin.; Hakim, E. H.; Juliawaty, L. D.; Syah, Y. M.; bin Din, L.; Ghisalberti, E. L.; Latip, J.; Said, I. M.; Achmad, S. A. Z. Naturforsch C. J. Biosci. 2005, 60, 723-727. https://doi.org/10.1515/znc-2005-9-1011
  6. Alley, M. C.; Scudiero, D. A.; Monks, A.; Hursey, M. L.; Czerwinski, M. J.; Fine, D. L.; Abbott, B. J.; Mayo, J. G.; Shoemaker, R. H.; Boyd, M. R. Cancer Res. 1988, 48, 589-601.
  7. McCarthy, F. O.; Chopra, J.; Ford, A.; Hogan, S. A.; Kerry, J. P.; O'Brien, N. M.; Ryan, E.; Maguire, A. R. Org. Biomol. Chem. 2005, 3, 3059-3065. https://doi.org/10.1039/b505069c
  8. Chang, Y. S.; Lin, M. S.; Jiang, R. L.; Huang, S. C.; Ho, L. K. Phytochemistry 1996, 42, 559-560. https://doi.org/10.1016/0031-9422(95)00935-3
  9. Khan, N. M. M. U.; Hossain, M. S. J. Pharmacognosy & Phytochemistry 2015, 4, 05-07.
  10. Gallo, M. B. C.; Cavalcanti, B. C.; Barros, F. W. A.; de Moraes, M. O.; Costa-Lotufo, L.V.; Pessoa, C.; Bastos, J. K.; Pupo, M. T. Chem. Biodivers. 2010, 7, 2941-2950. https://doi.org/10.1002/cbdv.201000011