Journal of Oriental Neuropsychiatry (동의신경정신과학회지)

The Korean Society of Oriental Neuropsychiatry (대한한방신경정신과학회)
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A Study on the Combination Effect of Herbal Medicine and Western Medicine on BPSD in Patients with Alzheimer's Disease: A Systematic Review

알츠하이머병 환자의 이상행동심리증상(BPSD)에 대한 한약과 양약의 병용 효과에 대한 연구: 체계적 문헌 고찰

  • Kim, Man-Gi (Department of Oriental Neuropsychiatry, College of Korean Medicine, Dongguk University) ;
  • Chang, Seok-Joo (Department of Pediatrics, College of Korean Medicine, Dongguk University) ;
  • Hong, Min-Ho (Department of Oriental Neuropsychiatry, College of Korean Medicine, Dongguk University) ;
  • Kim, Geun-Woo (Department of Oriental Neuropsychiatry, College of Korean Medicine, Dongguk University) ;
  • Koo, Byung-Soo (Department of Oriental Neuropsychiatry, College of Korean Medicine, Dongguk University)
  • 김만기 (동국대학교 한의과대학 한방신경정신과학교실) ;
  • 장석주 (동국대학교 한의과대학 한방소아청소년과학교실) ;
  • 홍민호 (동국대학교 한의과대학 한방신경정신과학교실) ;
  • 김근우 (동국대학교 한의과대학 한방신경정신과학교실) ;
  • 구병수 (동국대학교 한의과대학 한방신경정신과학교실)
  • Received : 2020.11.30
  • Accepted : 2020.12.18
  • Published : 2020.12.30
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Abstract

Objectives: The purpose of this study was to provide clinical evidence to support the use of herbal medicine combined with western medicine for BPSD. Methods: Studies were identified by searching CNKI, Pubmed, EMBASE, Cochrane Library, SCIENCEON, RISS, KMbase, KISS, OASIS. Literature searches of Chinese, English, and Korean databases were performed. Two authors independently extracted the data and evaluated the quality of each study. Results: The literature search identified 203 articles. Of these, 7 were selected for the analysis. The risk of bias in most studies was unclear. The most frequently used diagnostic tools were the NINCDS-ADRDA and DSM-IV. The most commonly used results indicator was NPI. In 6 of the 7 papers, combination treatment (herbal & Western medicine) was statistically significantly more effective than single treatment (Western medicine alone) for BPSD. No significant adverse events were reported. Conclusions: Herbal medicine in combination with Western medicine is more effective for treating BPSD than Western medicine alone. However, the quality of the studies used in this study was uncertain and the sample size was too small. Based on the findings of this study, more high-quality clinical trials are needed to confirm the efficacy of combination treatment.

Keywords

Acknowledgement

This study was supported by the Convergence of Conventional Medicine and Traditonal Korean Medicine R&D Program funded by the Ministry of Health & Welfare through the Korea Health Industry Development Institute (KHIDI) (HI20C0866).

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