한국해양바이오학회지 (Journal of Marine Bioscience and Biotechnology)

한국해양바이오학회 (The Korean Society for Marine Biotechnology)
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Red Sea Cucumber (Stichopus japonicus) Suppresses Cancer Progression by Promoting the ROS-Me diated Inhibition of the MAPK Pathway

  • Kim, Jusnseong (Jeju Marine Research Center, Korea Institute of Ocean Science and Technology (KIOST)) ;
  • Kim, Eun-A (Jeju Marine Research Center, Korea Institute of Ocean Science and Technology (KIOST)) ;
  • Kang, Nalae (Jeju Marine Research Center, Korea Institute of Ocean Science and Technology (KIOST)) ;
  • Choi, Youn Kyung (Department of Medicine, School of Medicine, Jeju National University) ;
  • Heo, Soo-Jin (Jeju Marine Research Center, Korea Institute of Ocean Science and Technology (KIOST))
  • 투고 : 2020.07.03
  • 심사 : 2020.12.24
  • 발행 : 2020.12.31
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초록

Stichopus japonicas (red sea cucumbers) inhabit the coastal sea surrounding Jeju Island, South Korea, and are thought to have various medicinal properties. In this study, we investigated the anticancer activity of a red sea cucumber (S. japonicus) collected from Jeju Island. We obtained the red sea cucumber extract (RSCE), and observed that it inhibited the tumor cell growth and increased reactive oxygen species (ROS) production associated with the induction of apoptosis through the mitogen-activated protein kinase (MAPK) pathway in murine colon carcinoma cells (CT-26). Treatment with RSCE and N-acetylcysteine, which is a ROS scavenger, increased ROS production and apoptosis via the regulation by the MAPK pathway on the ERK and JNK compared with the nontreated group. Therefore, RSCE promotes ROS-mediated suppression of the ERK and JNK activation, and subsequently inhibits cancer progression, suggesting that RSCE may be beneficial in treating colon carcinoma.

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