Journal of The Korean Society of Clinical Toxicology (대한임상독성학회지)

Korean society of Clincal Toxicology (대한임상독성학회)
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Initial Serum Ammonia as a Predictor of Mortality in Patients with Acute Glufosinate Ammonium Herbicide Poisoning

글루포시네이트 암모늄 제초제 중독환자에서 혈중 암모니아 농도와 사망률과의 연관성에 대한 연구

  • Ko, Eun Na Lae (Department of Emergency Medicine, Gyeongsang National University School of Medicine) ;
  • Kim, Dong Hoon (Department of Emergency Medicine, Gyeongsang National University School of Medicine) ;
  • Lee, Soo Hoon (Department of Emergency Medicine, Gyeongsang National University School of Medicine) ;
  • Jeong, Jin Hee (Department of Emergency Medicine, Gyeongsang National University School of Medicine) ;
  • Lee, Sang Bong (Department of Emergency Medicine, Gyeongsang National University School of Medicine) ;
  • Sung, Aejin (Department of Emergency Medicine, Gyeongsang National University School of Medicine) ;
  • Suh, Ja Hyoen (Department of Emergency Medicine, Gyeongsang National University School of Medicine) ;
  • Kang, Changwoo (Department of Emergency Medicine, Gyeongsang National University School of Medicine)
  • 고은나래 (경상대학교 의과대학/의학전문대학원 응급의학교실) ;
  • 김동훈 (경상대학교 의과대학/의학전문대학원 응급의학교실) ;
  • 이수훈 (경상대학교 의과대학/의학전문대학원 응급의학교실) ;
  • 정진희 (경상대학교 의과대학/의학전문대학원 응급의학교실) ;
  • 이상봉 (경상대학교 의과대학/의학전문대학원 응급의학교실) ;
  • 성애진 (경상대학교 의과대학/의학전문대학원 응급의학교실) ;
  • 서자현 (경상대학교 의과대학/의학전문대학원 응급의학교실) ;
  • 강창우 (경상대학교 의과대학/의학전문대학원 응급의학교실)
  • Received : 2020.08.11
  • Accepted : 2020.10.21
  • Published : 2020.12.31
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Abstract

Purpose: The association of the initial serum ammonia level with in-hospital mortality in patients with acute glufosinate-ammonium herbicide poisoning was studied. Methods: This retrospective cohort study was conducted between March 2012 and August 2019 in the emergency department after glufosinate-ammonium herbicide poisoning. Survivors and non-survivors were analyzed using a Mann-Whitney U test and Fisher's exact test. Multivariate logistic regression analysis was performed to determine the independent risk factors for mortality. Results: One hundred and six patients were enrolled; 11 died, yielding a mortality of 10.4%. The serum bicarbonate level was significantly lower in the non-survival group than the survival group. Age, serum ammonia, blood urea nitrogen, creatinine levels, SOFA score, and APACHE II score were significantly higher in the non-survival group than the survival group. Age, serum ammonia, and creatinine level were independent risk factors for mortality in multivariate logistic regression analysis. Conclusion: The initial serum ammonia level is associated with mortality in patients with acute glufosinate herbicide poisoning.

Keywords

References

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