Journal of The Korean Society of Clinical Toxicology (대한임상독성학회지)

Korean society of Clincal Toxicology (대한임상독성학회)
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Predicting Factors Associated with Large Amounts of Glyphosate Intoxication in the Early-Stage Emergency Department: QTc Interval Prolongation

응급실 초기에 다량의 글라이포세이트 중독과 관련된 예측인자: QTc 간격 연장

  • Kyung, Dong-Soo (Department of Emergency Medicine, Keimyung University Dongsan Medical Center) ;
  • Jeon, Jae-Cheon (Department of Emergency Medicine, Keimyung University Dongsan Medical Center) ;
  • Choi, Woo Ik (Department of Emergency Medicine, Keimyung University Dongsan Medical Center) ;
  • Lee, Sang-Hun (Department of Emergency Medicine, Keimyung University Dongsan Medical Center)
  • 경동수 (계명대학교 의과대학 응급의학교실) ;
  • 전재천 (계명대학교 의과대학 응급의학교실) ;
  • 최우익 (계명대학교 의과대학 응급의학교실) ;
  • 이상훈 (계명대학교 의과대학 응급의학교실)
  • Received : 2020.07.31
  • Accepted : 2020.09.16
  • Published : 2020.12.31
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Abstract

Purpose: Taking large amounts of glyphosate is life-threatening, but the amounts of glyphosate taken by patients for suicide are not known precisely. The purpose of this study was to find the predictors of large amounts of glyphosate ingestion. Methods: This retrospective study analyzed patients presenting to an emergency department with glyphosate intoxication between 2010 and 2019, in a single tertiary hospital. The variables associated with the intake amounts were investigated. The parameters were analyzed by multivariate variate logistic regression analyses and the receiver operating characteristic (ROC) curve. Results: Of the 28 patients with glyphosate intoxication, 15 (53.6%) were in the large amounts group. Univariate analysis showed that metabolic acidosis, lactic acid, and corrected QT (QTc) interval were significant factors. In contrast, multivariate analysis presented the QTc interval as the only independent factor with intoxication from large amounts of glyphosate. (odds ratio, 95% confidence interval: 1.073, 1.011-1.139; p=0.020) The area under the ROC curve of the QTc interval was 0.838. Conclusion: The QTc interval is associated significantly with patients who visit the emergency department after being intoxicated by large amounts of glyphosate. These conclusions will help in the initial triage of patients with glyphosate intoxication.

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References

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