Biomedical Science Letters (대한의생명과학회지)

The Korean Society for Biomedical Laboratory Sciences (대한의생명과학회)
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Effect of Euterpe oleracea Mart. (acai berry) Extract on Skin Flap Survival in Mice

  • Jung, Sangbong (Department of Medical Laboratory Science, Dongeui Institute of Technology) ;
  • Kim, Jongsik (Department of Anatomy, College of Medicine, Kosin University) ;
  • Kim, Eun-Joong (Department of Clinical Laboratory Science, Chungbuk Health and Science University) ;
  • Rhee, Ki-Jong (Department of Biomedical Laboratory Science, Yonsei University MIRAE Campus)
  • Received : 2019.08.05
  • Accepted : 2019.09.16
  • Published : 2019.09.30
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Abstract

Skin flap necrosis remains a major complication of reconstructive surgery. Euterpe oleracea Mart., popularly known as "acai berry" contains hydroxybenzoic acid, antioxidant polyphenolics and anthocyanins. These and other compounds within the acai berry confer anti-inflammatory and anti-oxidative effects. In this current study, we evaluated the protective effect of acai berry extracts on survival of random-pattern skin flaps in a murine model by histologic analysis. ICR mice were subjected to skin elevation surgery and orally administered acai berry extract (100 mg/kg) daily for 7 days. Tissues were stained with hematoxylin-eosin or Masson's trichrome to observe tissue integrity and collagen deposition. In addition, $TGF-{\beta}$ and VEGF was stained by immunofluorescence to determine anti-inflammatory cell infiltration and neovascularization, respectively. We found a decrease in inflammatory cell infiltration and increase in collagen deposition in the acai berry extract treated mice compared to control mice. Immunofluorescence staining reveal a higher number of $TGF-{\beta}$ positive cells and enhanced VEGF staining in the acai berry extract treated mice. The results from this study indicate that oral uptake of acai berry extract can promote healing and survival of surgical skin flaps in mice providing an augmentative therapeutic approach to enhancing skin flap survival.

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References

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