Journal of Radiation Industry (방사선산업학회지)

Korean Society of Radiation Industry (한국방사선산업학회)
권호 표지

Synthesis and Characterization of Manuka Honey Loaded Carboxymethyl Cellulose Hydrogel Prepared by Gamma-ray Irradiation

  • Park, Jong-Seok (Advanced Radiation Technology Institute, Korea Atomic Energy Research Institute) ;
  • Jeong, Jin-Oh (Advanced Radiation Technology Institute, Korea Atomic Energy Research Institute) ;
  • Gwon, Hui-Jeong (Advanced Radiation Technology Institute, Korea Atomic Energy Research Institute) ;
  • Jeong, Sung-In (Advanced Radiation Technology Institute, Korea Atomic Energy Research Institute) ;
  • Nho, Young-Chang (EB TECH CO., LTD) ;
  • Lim, Youn-Mook (Advanced Radiation Technology Institute, Korea Atomic Energy Research Institute)
  • Received : 2019.07.04
  • Accepted : 2019.08.16
  • Published : 2019.09.30

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Abstract

Manuka honey differs from normal honey because of its additional existence of non-peroxide antibacterial activity which has been used to treat infections in a wide range of wound types. In this study, Manuka honey mixed with carboxymethyl cellulose (CMC) was crosslinked and sterilized by using a γ-irradiation of 50 kGy from a 60Co source to make a new hydrogel wound dressing. The effects of various parameters such as honey concentration (0~20 wt%), gel content, and the absorption ratio in water were investigated in detail. The antibacterial properties were evaluated by paper diffusion test. The antibacterial tests indicated that the manuka/CMC hydrogels have a good antibacterial activity against Escherichia coli (E. coli) and Staphylococcus aureus(S. aureus). As effective therapeutic evidence, the rate of vivo wound healing process in db/db mice was investigated based on real-time photographs and wound area contraction.

Keywords

Acknowledgement

This work was supported by National Research Foundation of Korea (NRF) grant funded by the Ministry of Science, ICT (Information & Communication Technology) and Future Planning, Korea government.

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