Journal of Sasang Constitutional Medicine (사상체질의학회지)

The Society Of Sasang Constitutional Medicine (사상체질의학회)
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Clinical Study on Nonalcoholic Fatty Liver Disease Related Factors: Tumor Marker, Heart Rate Variability, Sasang Constitution

비알코올성지방간의 유관 인자 임상 연구: 종양표지자, 심박변이도, 사상체질

  • Gwak, Si-Ra (Dept. of Sasang Constitutional Medicine, College of Korean Medicine, Wonkwang University) ;
  • Shen, Lei (Dept. of Sasang Constitutional Medicine, College of Korean Medicine, Wonkwang University) ;
  • Park, Soo-Jung (Dept. of Sasang Constitutional Medicine, College of Korean Medicine, Woosuk University) ;
  • Kwon, Young-Mi (Dept. of Radiology, College of Korean Medicine, Wonkwang University) ;
  • Joo, Jong-Cheon (Dept. of Sasang Constitutional Medicine, College of Korean Medicine, Wonkwang University)
  • 곽시라 (원광대학교 한의과대학 사상체질과) ;
  • 신뢰 (원광대학교 한의과대학 사상체질과) ;
  • 박수정 (우석대학교 한의과대학 사상체질과) ;
  • 권영미 (원광대학교 한의과대학 영상의학과) ;
  • 주종천 (원광대학교 한의과대학 사상체질과)
  • Received : 2019.06.14
  • Accepted : 2019.06.25
  • Published : 2019.06.30
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Abstract

Objectives The aim of this study is to investigate the related factors of nonalcoholic fatty liver disease (NAFLD). Methods The subjects were 187 persons diagnosed as fatty liver by abdominal ultrasonography. They were divided into three groups according to the severity of fatty liver: control, mild, moderate or severe. The three groups' general characteristics, laboratory results, liver function indexes, metabolic syndrome indexes, tumor markers, heart rate variability values and Sasang constitution distribution were compared and analyzed. Results Male ratio, height, weight, body mass index, red blood cell count, hemoglobin level and creatinine level were higher in NAFLD groups than in control group. The levels of sodium and amylase were higher in control than in NAFLD. In liver function, the levels of aspartate transaminase, alanine transaminase and gamma-glutamyl transpepsidase of NAFLD were higher. In metabolic syndrome index, systolic blood pressure, diastolic blood pressure, waist circumference, total cholesterol, triglyceride and low density lipoprotein cholesterol levels were higher in NAFLD, while high density lipoprotein cholesterol level was higher in control. The alpha-feto protein level was higher in NAFLD, and the heart rate variability was not different between NAFLD and control groups. In Sasang constitution, Taeeumin ratio of NAFLD was higher than of control. Conclusions The results suggest that nonalcoholic fatty liver is clinically related to liver dysfunction, metabolic syndrome, tumor markers, and Sasang constitution. Further studies are needed to control nonalcoholic fatty liver disease and prevent severe disease such as cirrhosis and cancer caused by fatty liver.

Keywords

Table 1. General Characteristics and Other Laboratory Results of Nonalcoholic Fatty Liver Disease and Control Groups

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Table 2. Liver Function Indexes of Nonalcoholic Fatty Liver Disease and Control Groups

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Table 3. Metabolic Syndrome Indexes of Nonalcoholic Fatty Liver Disease and Control Groups

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Table 4. Tumor Markers of Nonalcoholic Fatty Liver Disease and Control Groups

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Table 5. Heart Rate Variability Values of Nonalcoholic Fatty Liver Disease and Control Groups

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Table 6. Sasang Constitution Distribution of Nonalcoholic Fatty Liver Disease and Control Groups

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