생명과학회지 (Journal of Life Science)

  • 제29권6호
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  • Pages.740-746
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  • 2019
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  • 1225-9918(pISSN)
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  • 2287-3406(eISSN)
한국생명과학회 (Korean Society of Life Science)
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운동이 치매 환자의 수면 관련 인자, 치매 관련 인자에 미치는 영향

Effects of Exercise on Sleep Quality and Dementia-related Factors of Dementia Patients

  • Yoon, Byung Kon (DEU Exe-Physio Lab, Department of Physical Education, Dong-Eui University) ;
  • Kim, Jong Jin (DEU Exe-Physio Lab, Department of Physical Education, Dong-Eui University) ;
  • Kwak, Yi Sub (DEU Exe-Physio Lab, Department of Physical Education, Dong-Eui University)
  • 투고 : 2019.06.04
  • 심사 : 2019.06.21
  • 발행 : 2019.06.30
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⟨ 이전 논문 다음 논문 ⟩

초록

운동은 치매에 긍정적인 영향을 줄 수 있다고 잘 알려져 있다. 그러나 대부분의 치매 관련 연구에서는 치매의 증상 완화, 치매에 관한 다양한 치료 및 약물 치료에 대한 연구가 대부분이었다. 규칙적인 운동은 뇌 기능과 치매예방에 중요한 역할을 하지만, 치매와 뇌 기능에 대한 운동의 효과를 나타내는 연구는 부족한 실정이다. 본 연구에서는 운동이 수면 관련 인자(melatonin, serotonin), 치매 관련 인자(BDNF, beta-amyloid, IGF-1, Irisin, GLUT)에 미치는 영향에 대해 연구하고자 한다. 본 연구는 Myokine (Irisin, IGF-1), GLUT 및 Melatonin이 지구성 운동을 통한 BDNF 활성화를 통해 치매 증상을 개선하거나 지연시키는 중요한 인자라는 것을 밝혀냈다. 그러나 이러한 결과는 다양한 종류의 운동 유형, 형태, 기간 및 운동 강도 등에 따라 다른 결과가 나타나서 논란의 여지가 있다. 그러므로 추후 운동과 치매에 관한 기전적인 연구분석이 필요하다.

It is well known that exercise may have a positive effects on dementia. However, most of dementia-related studies were performed about symptom care, diverse treatment and drug treatment. Although regular physical exercise plays an important role of brain function and dementia prevention, only a few research studies showed the effect of physical exercise on dementia and brain function. This study is to investigate about the sleep-related factors (melatonin, serotonin), dementia-related factors (BDNF, beta-amyloid, IGF-1, Irisin, GLUT) with physical exercise. This study revealed that Myokine (Irisin, IGF-1), GLUT and Melatonin is an important factors to improve or sometimes delay the symptoms of dementia through BDNF activation following endurance exercise. However, these results were controversal following the various kinds of exercise type, mode, duration and exercise intensity and so forth. Therefore, further mechanism study about exercise and dementia is urgently needed in this area.

키워드

SMGHBM_2019_v29n6_740_f0001.png 이미지

Fig. 1. Mechanisms of cause to different type of dementia.

SMGHBM_2019_v29n6_740_f0002.png 이미지

Fig. 2. Mechanisms of STZ cause to dementia.

SMGHBM_2019_v29n6_740_f0003.png 이미지

Fig. 3. Combined effects of physical exercise, dementia and sleep-related factors on dementia.

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