Natural Product Sciences

The Korean Society of Pharmacognosy (한국생약학회)
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Chemical Constituents of Impatiens balsamina Stems and Their Biological Activities

  • Kim, Dong Hyun (Natural Products Laboratory, School of Pharmacy, Sungkyunkwan University) ;
  • Lee, Tae Hyun (Natural Products Laboratory, School of Pharmacy, Sungkyunkwan University) ;
  • Subedi, Lalita (Gachon Institute of Parmaceutical Science, Gachon University) ;
  • Kim, Sun Yeou (Gachon Institute of Parmaceutical Science, Gachon University) ;
  • Lee, Kang Ro (Natural Products Laboratory, School of Pharmacy, Sungkyunkwan University)
  • Received : 2018.11.27
  • Accepted : 2018.12.12
  • Published : 2019.06.30
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Abstract

The purification of the MeOH extract from Impatiens basamina by repeated column chromatography led to the isolation of one new tetrahydronaphthalene (1), together with eleven known compounds (2 - 12). The structure of the new compound (1) was determined by spectral data analysis ($^1H$ and $^{13}C$-NMR, $^1H-^1H$ COSY, HSQC, HMBC, NOESY, and HR-ESI-MS). Isolated compounds (1 - 12) were evaluated for their inhibitory effects on NO production in LPS-activated murine microglial BV-2 cells and their effects on NGF secretion from C6 glioma cells. Compounds 3, 7, and 10 reduced NO levels in LPS-activated murine microglial cells with $IC_{50}$ values of 26.89, 25.59, and $44.21{\mu}M$, respectively. Compounds 1, 5, and 9 upregulated NGF secretion to $153.09{\pm}4.66$, $156.88{\pm}8.86$, and $157.34{\pm}3.30%$, respectively.

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