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Potential Implications of Long Noncoding RNAs in Autoimmune Diseases

  • Keun Hur (Department of Biochemistry and Cell Biology, School of Medicine, Kyungpook National University) ;
  • Sang-Hyon Kim (Division of Rheumatology, Department of Internal Medicine, Keimyung University Dongsan Medical Center, Keimyung University College of Medicine) ;
  • Ji-Min Kim (Division of Rheumatology, Department of Internal Medicine, Keimyung University Dongsan Medical Center, Keimyung University College of Medicine)
  • Received : 2018.11.15
  • Accepted : 2019.02.17
  • Published : 2019.02.28
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Abstract

Long noncoding RNAs (lncRNAs) are non-protein coding RNAs of more than 200 nucleotides in length. Despite the term "noncoding", lncRNAs have been reported to be involved in gene expression. Accumulating evidence suggests that lncRNAs play crucial roles in the regulation of immune system and the development of autoimmunity. lncRNAs are expressed in various immune cells including T lymphocytes, B lymphocytes, macrophages, neutrophils, dendritic cells, and NK cells, and are also involved in the differentiation and activation of these immune cells. Here, we review recent studies on the role of lncRNAs in immune regulation and the differential expression of lncRNAs in various autoimmune diseases.

Keywords

Acknowledgement

This work was supported by the National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIP) (No. 2016R1C1B1016617).

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