Journal of Life Science (생명과학회지)

Korean Society of Life Science (한국생명과학회)
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Anti-obesity and Anti-diabetes Effects of the Fermented White Jelly Fungus (Tremella fuciformis Berk) Using Lactobacillus rhamnosus BHN-LAB 76

유산균을 이용한 흰목이 버섯의 발효를 통한 항비만과 항당뇨 효과

  • Lee, Jun-Hyeong (Institute for Development of Bioindustrial Materials, BHNBIO Co., LTD.) ;
  • Kim, Byung-Hyuk (Institute for Development of Bioindustrial Materials, BHNBIO Co., LTD.) ;
  • Yoon, Yeo-Cho (Institute for Development of Bioindustrial Materials, BHNBIO Co., LTD.) ;
  • Kim, Jung-Gyu (Institute for Development of Bioindustrial Materials, BHNBIO Co., LTD.) ;
  • Park, Ye-Eun (Institute for Development of Bioindustrial Materials, BHNBIO Co., LTD.) ;
  • Park, Hye-Suk (Institute for Development of Bioindustrial Materials, BHNBIO Co., LTD.) ;
  • Hwang, Hak-Soo (Kyochon F&B Co., LTD.) ;
  • Kwun, In-Sook (Department of Food Science and Nutrition, Andong National University) ;
  • Kwon, Gi-Seok (Divistion of Horticulture & Medicinal Plant, Andong National University) ;
  • Lee, Jung-Bok (Institute for Development of Bioindustrial Materials, BHNBIO Co., LTD.)
  • 이준형 (비에이치앤바이오 기업부설 생물산업소재개발연구소) ;
  • 김병혁 (비에이치앤바이오 기업부설 생물산업소재개발연구소) ;
  • 윤여초 (비에이치앤바이오 기업부설 생물산업소재개발연구소) ;
  • 김중규 (비에이치앤바이오 기업부설 생물산업소재개발연구소) ;
  • 박예은 (비에이치앤바이오 기업부설 생물산업소재개발연구소) ;
  • 박혜숙 (비에이치앤바이오 기업부설 생물산업소재개발연구소) ;
  • 황학수 (교촌 F&B) ;
  • 권인숙 (안동대학교 식품영양학과) ;
  • 권기석 (안동대학교 원예.생약융합학부) ;
  • 이중복 (비에이치앤바이오 기업부설 생물산업소재개발연구소)
  • Received : 2018.11.27
  • Accepted : 2019.04.19
  • Published : 2019.04.30
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Abstract

White jelly fungus (Tremella fuciformis Berk) is effective for hypertension, diabetes, obesity, lung disease, beauty, and has been known as an elixir of life in ancient Chinese dynasty. In this study, we investigated the anti-obesity and diabetic effects of the fermented white jelly fungus extract by the bioconversion process. We fed an obesity-inducing mouse with 5% non-fermented Tremella fuciformis (TF), 2.5% fermented Tremella fuciformis (FTF), and 5% FTF containing High Fats Diet (HFD) and HFD for 8 weeks, respectively. The oral glucose tolerance test (OGTT) was performed analysis after 7 weeks of feeding and the dietary intake, food efficiency ratio, body weight, liver, epididymal fat weight, and serum insulin level were measured after 8 weeks of feeding. Also, HOMA-IR was analyzed. The concentrations of serum total cholesterol, triglycerides test was analyzed. The FTF compare with 5% TF and HFD confirmed that 5% FTF reduced body weight, tissue weight, triglycerides concentration, HOMA-IR, respectively. As a result, we confirmed that the fermented white jelly fungus has the anti-obesity effect. Finally, this study can be used a basic data for obesity treatment using fermented white jelly fungus.

흰목이 버섯(Tremella fuciformis Berk)은 고혈압, 당뇨병, 비만, 폐질환, 미용에 효과가 있으며, 고대 중국에서는 불로장생약이라고 알려져 있다. 본 연구에서는 생물전환공정을 통해 발효된 흰목이 버섯 추출물의 항비만 및 당뇨병 효과를 조사하였다. 우리는 비만 유도 시킨 C57BL / 6N 마우스에 High Fats Diet (HFD), 5% non-fermented Tremella fuciformis (TF), 2.5% fermented Tremilla fuciformis (FTF), 5% FTF를 8주간 투여하였다. 경구당 부하검사는 7주간 식이섭취 후 실시하였으며, 8주간 식이섭취 후 섭취량, 식이섭취효율, 체중, 간, 부고환 지방량 및 혈청 인슐린 수치 및 HOMA-IR을 분석하였다. 또한, 혈청 총콜레스테롤 함량 및 중성지방 함량을 분석하였다. FTF (실험)군과 TF (실험)군 및 HFD (실험)군과 비교한 결과 5% FTF (실험)군이 체중, 조직 중량, 중성지방 함량 및 HOMA-IR을 감소시키는 것을 확인하였다. 이 결과를 통해 발효 흰목이 버섯은 항비만 효과를 확인하였다. 마지막으로, 본 연구는 발효 흰목이 버섯을 이용한 비만 치료의 기초자료로 사용하고자 한다.

Keywords

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Fig. 1. Liver and epididymal fat weight of mice fed experimental diets supplemented with fermented White jelly fungus (Tremella fuciformis Berk) at 1% of diets for 8 weeks.

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Fig. 2. AUC (Area under the curve) calculation after glucose treatment in mice fed experimental diets supplemented with fermented White jelly fungus (Tremella fuciformis Berk) at 1% of diets for 8 weeks.

Table 1. Composition of experimental diets

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Table 2. Effect of fermented white jelly fungus (Tremella fuciformis Berk) powder on final body weight, food intake and food efficiency ratio

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Table 3. The lipid profiles of each experimental group after 8 weeks

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Table 4. Effects of the fermented white jelly fungus (Tremella fuciformis Berk) on serum glucose and insulin levels in mouse

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