Journal of Korean Neurosurgical Society

  • 제62권2호
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  • Pages.166-174
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  • 2019
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  • 2005-3711(pISSN)
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  • 1598-7876(eISSN)
대한신경외과학회 (The Korean Neurosurgical Society)
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Change of Extracellular Glutamate Level in Striatum during Deep Brain Stimulation of the Entopeduncular Nucleus in Rats

  • Lee, Hyun-ju (Department of Science in Korean Medicine, Graduate School, College of Korean Medicine, Kyung Hee University) ;
  • Sung, Jae Hoon (Department of Neurosurgery, St. Vincent's Hospital, College of Medicine, The Catholic University of Korea) ;
  • Hong, Jae Taek (Department of Neurosurgery, St. Vincent's Hospital, College of Medicine, The Catholic University of Korea) ;
  • Kim, Il Sup (Department of Neurosurgery, St. Vincent's Hospital, College of Medicine, The Catholic University of Korea) ;
  • Yang, Seung Ho (Department of Neurosurgery, St. Vincent's Hospital, College of Medicine, The Catholic University of Korea) ;
  • Cho, Chul Bum (Department of Neurosurgery, St. Vincent's Hospital, College of Medicine, The Catholic University of Korea)
  • 투고 : 2018.05.31
  • 심사 : 2018.07.24
  • 발행 : 2019.03.01
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초록

Objective : Globus pallidus interna (GPi) is acknowledged as an essential treatment for advanced Parkinson's disease (PD). Nonetheless, the neurotransmitter study about its results is undiscovered. The goal of this research was to examine influences of entopeduncular nucleus (EPN) stimulation, identical to human GPi, in no-lesioned (NL) rat and 6-hydroxydopamine (6-HD)-lesioned rat on glutamate change in the striatum. Methods : Extracellular glutamate level changes in striatum of NL category, NL with deep brain stimulation (DBS) category, 6-HD category, and 6-HD with DBS category were examined using microdialysis and high-pressure liquid chromatography. Tyrosine hydroxylase (TH) immunoreactivities in substantia nigra and striatum of the four categories were also analyzed. Results : Extracellular glutamate levels in the striatum of NL with DBS category and 6-HD with DBS category were significantly increased by EPN stimulation compared to those in the NL category and 6-HD category. EPN stimulation had no significant effect on the expression of TH in NL or 6-HD category. Conclusion : Clinical results of GPi DBS are not only limited to direct inhibitory outflow to thalamus. They also include extensive alteration within basal ganglia.

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참고문헌

  1. Abosch A, Kapur S, Lang AE, Hussey D, Sime E, Miyasaki H, et al. : Stimulation of the subthalamic nucleus in Parkinson's disease does not produce striatal dopamine release. Neurosurgery 53 : 1095-1102; discussion 1102-1105, 2003 https://doi.org/10.1227/01.NEU.0000088662.69419.1B
  2. Agnesi F, Blaha CD, Lin J, Lee KH : Local glutamate release in the rat ventral lateral thalamus evoked by high-frequency stimulation. J Neural Eng 7 : 26009, 2010 https://doi.org/10.1088/1741-2560/7/2/026009
  3. Bar-Gad I, Elias S, Vaadia E, Bergman H : Complex locking rather than complete cessation of neuronal activity in the globus pallidus of a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated primate in response to pallidal microstimulation. J Neurosci 24 : 7410-7419, 2004 https://doi.org/10.1523/JNEUROSCI.1691-04.2004
  4. Barneoud P, Parmentier S, Mazadier M, Miquet JM, Boireau A, Dubedat P, et al. : Effects of complete and partial lesions of the dopaminergic mesotelencephalic system on skilled forelimb use in the rat. Neuroscience 67 : 837-848, 1995 https://doi.org/10.1016/0306-4522(95)00112-V
  5. Boulet S, Lacombe E, Carcenac C, Feuerstein C, Sgambato-Faure V, Poupard A, et al. : Subthalamic stimulation-induced forelimb dyskinesias are linked to an increase in glutamate levels in the substantia nigra pars reticulata. J Neurosci 26 : 10768-10776, 2006 https://doi.org/10.1523/JNEUROSCI.3065-06.2006
  6. Bruet N, Windels F, Carcenac C, Feuerstein C, Bertrand A, Poupard A, et al. : Neurochemical mechanisms induced by high frequency stimulation of the subthalamic nucleus: increase of extracellular striatal glutamate and GABA in normal and hemiparkinsonian rats. J Neuropathol Exp Neurol 62 : 1228-1240, 2003 https://doi.org/10.1093/jnen/62.12.1228
  7. DeLong MR : Primate models of movement disorders of basal ganglia origin. Trends Neurosci 13 : 281-285, 1990 https://doi.org/10.1016/0166-2236(90)90110-V
  8. DeLong MR, Wichmann T : Basal ganglia circuits as targets for neuromodulation in Parkinson disease. JAMA Neurol 72 : 1354-1360, 2015 https://doi.org/10.1001/jamaneurol.2015.2397
  9. Gubellini P, Eusebio A, Oueslati A, Melon C, Kerkerian-Le Goff L, Salin P : Chronic high-frequency stimulation of the subthalamic nucleus and L-DOPA treatment in experimental parkinsonism: effects on motor behaviour and striatal glutamate transmission. Eur J Neurosci 24 : 1802-1814, 2006 https://doi.org/10.1111/j.1460-9568.2006.05047.x
  10. Hazrati LN, Parent A : Differential patterns of arborization of striatal and subthalamic fibers in the two pallidal segments in primates. Brain Res 598 : 311-315, 1992 https://doi.org/10.1016/0006-8993(92)90199-J
  11. Jonkers N, Sarre S, Ebinger G, Michotte Y : MK801 suppresses the LDOPA-induced increase of glutamate in striatum of hemi-Parkinson rats. Brain Res 926 : 149-155, 2002 https://doi.org/10.1016/S0006-8993(01)03147-X
  12. Lanciego JL, Gonzalo N, Castle M, Sanchez-Escobar C, Aymerich MS, Obeso JA : Thalamic innervation of striatal and subthalamic neurons projecting to the rat entopeduncular nucleus. Eur J Neurosci 19 : 1267-1277, 2004 https://doi.org/10.1111/j.1460-9568.2004.03244.x
  13. Lang AE, Widner H : Deep brain stimulation for Parkinson's disease: patient selection and evaluation. Mov Disord 17 Suppl 3 : S94-S101, 2002 https://doi.org/10.1002/mds.10149
  14. Lee KH, Kristic K, van Hoff R, Hitti FL, Blaha C, Harris B, et al. : Highfrequency stimulation of the subthalamic nucleus increases glutamate in the subthalamic nucleus of rats as demonstrated by in vivo enzymelinked glutamate sensor. Brain Res 1162 : 121-129, 2007 https://doi.org/10.1016/j.brainres.2007.06.021
  15. Lee KJ, Shim I, Sung JH, Hong JT, Kim IS, Cho CB : Striatal glutamate and GABA after high frequency subthalamic stimulation in parkinsonian rat. J Korean Neurosurg Soc 60 : 138-145, 2017 https://doi.org/10.3340/jkns.2016.0202.020
  16. Liu Y, Li W, Tan C, Liu X, Wang X, Gui Y, et al. : Meta-analysis comparing deep brain stimulation of the globus pallidus and subthalamic nucleus to treat advanced Parkinson disease. J Neurosurg 121 : 709-718, 2014 https://doi.org/10.3171/2014.4.JNS131711
  17. McConnell GC, So RQ, Hilliard JD, Lopomo P, Grill WM : Effective deep brain stimulation suppresses low-frequency network oscillations in the basal ganglia by regularizing neural firing patterns. J Neurosci 32 : 15657-15668, 2012 https://doi.org/10.1523/JNEUROSCI.2824-12.2012
  18. McIntyre CC, Savasta M, Kerkerian-Le Goff L, Vitek JL : Uncovering the mechanism(s) of action of deep brain stimulation: activation, inhibition, or both. Clin Neurophysiol 115 : 1239-1248, 2004 https://doi.org/10.1016/j.clinph.2003.12.024
  19. Meissner W, Paul G, Reum T, Reese R, Sohr R, Morgenstern R, et al. : The influence of pallidal deep brain stimulation on striatal dopaminergic metabolism in the rat. Neurosci Lett 296 : 149-152, 2000 https://doi.org/10.1016/S0304-3940(00)01659-1
  20. Moon HC, Won SY, Kim EG, Kim HK, Cho CB, Park YS : Effect of optogenetic modulation on entopeduncular input affects thalamic discharge and behavior in an AAV2-${\alpha}$-synuclein-induced hemiparkinson rat model. Neurosci Lett 662 : 129-135, 2018 https://doi.org/10.1016/j.neulet.2017.10.019
  21. Odekerken VJ, van Laar T, Staal MJ, Mosch A, Hoffmann CF, Nijssen PC, et al. : Subthalamic nucleus versus globus pallidus bilateral deep brain stimulation for advanced Parkinson's disease (NSTAPS study): a randomised controlled trial. Lancet Neurol 12 : 37-44, 2013 https://doi.org/10.1016/S1474-4422(12)70264-8
  22. Papa SM, Engber TM, Kask AM, Chase TN : Motor fluctuations in levodopa treated parkinsonian rats: relation to lesion extent and treatment duration. Brain Res 662 : 69-74, 1994 https://doi.org/10.1016/0006-8993(94)90796-X
  23. Paxinos G : The rat nervous system, ed 3. San Diego : Elsevier Academic Press, 2004, pp49-56
  24. Sgambato-Faure V, Cenci MA : Glutamatergic mechanisms in the dyskinesias induced by pharmacological dopamine replacement and deep brain stimulation for the treatment of Parkinson's disease. Prog Neurobiol 96 : 69-86, 2012 https://doi.org/10.1016/j.pneurobio.2011.10.005
  25. Shipton EA : Movement disorders and neuromodulation. Neurol Res Int 2012 : 309431, 2012 https://doi.org/10.1155/2012/309431
  26. Stefani A, Fedele E, Galati S, Pepicelli O, Frasca S, Pierantozzi M, et al. : Subthalamic stimulation activates internal pallidus: evidence from cGMP microdialysis in PD patients. Ann Neurol 57 : 448-452, 2005 https://doi.org/10.1002/ana.20402
  27. Tan ZG, Zhou Q, Huang T, Jiang Y : Efficacies of globus pallidus stimulation and subthalamic nucleus stimulation for advanced Parkinson's disease: a meta-analysis of randomized controlled trials. Clin Interv Aging 11 : 777-786, 2016
  28. Temel Y, Visser-Vandewalle V, Aendekerk B, Rutten B, Tan S, Scholtissen B, et al. : Acute and separate modulation of motor and cognitive performance in parkinsonian rats by bilateral stimulation of the subthalamic nucleus. Exp Neurol 193 : 43-52, 2005 https://doi.org/10.1016/j.expneurol.2004.12.025
  29. Wichmann T, Delong MR : Deep-brain stimulation for basal ganglia disorders. Basal Ganglia 1 : 65-77, 2011 https://doi.org/10.1016/j.baga.2011.05.001