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Cellmed Orthocellular Medicine and Pharmaceutical Association (셀메드 세포교정의약학회)
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Therapeutic potential of traditional Korean music, Daegeum Sanjo in atopic dermatitis-like murine model

  • Ko, Kyung Ja (Department of Pharmacology, College of Korean Medicine, Kyung Hee University) ;
  • Yoou, Myoung-schook (Department of Pharmacology, College of Korean Medicine, Kyung Hee University) ;
  • Han, Na-Ra (Department of Pharmacology, College of Korean Medicine, Kyung Hee University)
  • Received : 2019.02.23
  • Accepted : 2019.02.27
  • Published : 2019.02.28
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Abstract

Atopic dermatitis (AD) is an allergic and inflammatory skin. Recently, the limitations and side effects of drug therapy, and possibility of alternative therapies, such as music therapy are emerging in the treatment of AD. Thus, the present study determined whether traditional Korean music, Daegeum Sanjo, regulates AD symptoms by comparing the rhythm, Jinyangjo-jangdan and Jungmori-jangdan in an AD-like murine model. Jinyangjo-jangdan and Jungmori-jangdan of Daegeum Sanjo reduced the duration of scratching behavior increased by DNFB challenge. Jinyangjo-jangdan and Jungmori-jangdan of Daegeum Sanjo attenuated clinical symptoms. However, Jinyangjo-jangdan and Jungmori-jangdan of Daegeum Sanjo did not inhibit IgE, histamine, interleukin (IL)-4, IL-6, or thymic stromal lymphopoietin levels in serum or AD-like skin lesions. In conclusion, the present study suggests that it is possible for Jinyangjo-jangdan and Jungmori-jangdan of Daegeum Sanjo to ameliorate AD symptoms. However, further study is needed to clarify significant mechanisms of Jinyangjo-jangdan and Jungmori-jangdan of Daegeum Sanjo therapy for AD symptoms.

Keywords

TJHOBI_2019_v9n1_5.1_f0001.png 이미지

Fig. 2 Atopic inflammatory mediators in serum of AD mice.

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Fig. 1 Scratching behavior in AD mice.

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Fig.3 Atopic inflammatory mediators in skin lesions of AD mice.

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