Journal of Digestive Cancer Reports

Korean Society of Gastrointestinal Cancer Research (대한소화기암연구학회)
권호 표지

Irreversible Electroporation in Patients with Pancreatic Cancer :Angel and Devil

비가역적 전기 천공술을 시행한 국소 진행형 췌장암 환자 2례

  • Keum, Jiyoung (Division of Gastroenterology, Department of Internal Medicine, Yonsei University College of Medicine) ;
  • Lee, Hee Seung (Division of Gastroenterology, Department of Internal Medicine, Yonsei University College of Medicine) ;
  • Kang, Huapyong (Division of Gastroenterology, Department of Internal Medicine, Yonsei University College of Medicine) ;
  • Jo, Jung Hyun (Division of Gastroenterology, Department of Internal Medicine, Yonsei University College of Medicine) ;
  • Chung, Moon Jae (Division of Gastroenterology, Department of Internal Medicine, Yonsei University College of Medicine) ;
  • Park, Jeong Youp (Division of Gastroenterology, Department of Internal Medicine, Yonsei University College of Medicine) ;
  • Park, Seung Woo (Division of Gastroenterology, Department of Internal Medicine, Yonsei University College of Medicine) ;
  • Song, Si Young (Division of Gastroenterology, Department of Internal Medicine, Yonsei University College of Medicine) ;
  • Bang, Seungmin (Division of Gastroenterology, Department of Internal Medicine, Yonsei University College of Medicine)
  • 금지영 (연세대학교 의과대학 내과학교실, 세브란스병원 소화기내과) ;
  • 이희승 (연세대학교 의과대학 내과학교실, 세브란스병원 소화기내과) ;
  • 강화평 (연세대학교 의과대학 내과학교실, 세브란스병원 소화기내과) ;
  • 조중현 (연세대학교 의과대학 내과학교실, 세브란스병원 소화기내과) ;
  • 정문재 (연세대학교 의과대학 내과학교실, 세브란스병원 소화기내과) ;
  • 박정엽 (연세대학교 의과대학 내과학교실, 세브란스병원 소화기내과) ;
  • 박승우 (연세대학교 의과대학 내과학교실, 세브란스병원 소화기내과) ;
  • 송시영 (연세대학교 의과대학 내과학교실, 세브란스병원 소화기내과) ;
  • 방승민 (연세대학교 의과대학 내과학교실, 세브란스병원 소화기내과)
  • Received : 2019.05.16
  • Accepted : 2019.06.11
  • Published : 2019.06.30

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Abstract

Pancreatic cancer has a very poor prognosis. Complete surgical resection remains the only current curative treatment. Locally advanced pancreatic cancer (LAPC) is considered as unresectable because of involvement of celiac and/or mesenteric vessels. The treatment of LAPC is a challenge. Current guidelines suggest systemic therapy. However, the majority of patients will never experience conversion to surgical resection. Thus, in these patients, ablation is an alternative therapy for local control, which causes local destruction while ideally avoiding injury to surrounding healthy tissue. Irreversible electroporation (IRE) is an energy delivery system, effective in ablating tumors by inducing irreversible membrane destruction of cells. IRE demonstrated to be safe in previous studies. However, it is not free from complications, even serious. Here, we reported two cases of the IRE in LAPC patients.

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