Kosin Medical Journal (고신대학교 의과대학 학술지)

Kosin University College of Medicine (고신대학교 의과대학)
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The effect of short-term particular matter2.5 exposure on asthma attacks in asthma children in Fukuoka, Japan

  • Lee, Song Han (Department of Pediatrics, Busan St. Mary's Hospital) ;
  • Lee, Koh Woon (Department of Pediatrics, Busan St. Mary's Hospital) ;
  • Hwang, Yoon Ha (Department of Pediatrics, Busan St. Mary's Hospital) ;
  • Odajima, Hiroshi (Department of Pediatrics, Fukuoka National Hospital)
  • Received : 2016.09.21
  • Accepted : 2016.10.24
  • Published : 2018.12.31
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Abstract

Objectives: We investigated whether asthma attacks in asthmatic children were caused by short-term exposure to particulate $matter(PM)_{2.5}$. Methods: Subjects were 411 patients who received inhalation therapy in National Fukuoka Hospital, from March to May 2013. All subjects were outpatients. We surveyed the air quality measurement results in the stations closest to the address of the patients. Data were used from the City of Fukuoka website data on air pollution. We carried out a case-crossover study and compared $PM_{2.5}$ concentration between 7 days after asthma attack occurred and the day asthma attack occurred and 1, 2 and 3 days before asthma attack occurred. Results: Highest hourly concentration of the day (OR 1.013, 95%CI 1.000-1.025) showed a significant association with 1 day before $PM_{2.5}$ concentration statistically. And 0-1 year-old infants were more vulnerable to the highest concentration of 1 day before $PM_{2.5}$ concentration(P < 0.05). Average concentration of $NO_2$ and $O_3$ and asthma attack also showed a significant association. Conclusions: Maximal daily $PM_{2.5}$ concentrations within 24 hours prior to the attack affect asthma exacerbation. 0-1 year-old infants are particularly vulnerable to $PM_{2.5}$ concentration. Asthma exacerbation is aggravated by $NO_2$ and $O_3$ concentration on the day of the asthma attack.

Keywords

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