임상이비인후과 (Journal of Clinical Otolaryngology Head and Neck Surgery)

  • 제29권2호
  • /
  • Pages.295-300
  • /
  • 2018
  • /
  • 1225-0244(pISSN)
  • /
  • 2713-833X(eISSN)
대한이비인후과학회 부산,울산,경남 지부회 (The Busan, Ulsan, Gyeoungnam Branch of Korean Society of Otolaryngology-Head and Neck Surgery)
권호 표지

측경부에 발생한 다형성 지방육종 1예

A Case of Pleomorphic Liposarcoma of the Lateral Neck

  • 손정협 (인제대학교 의과대학 상계백병원 이비인후과) ;
  • 김현정 (인제대학교 의과대학 상계백병원 병리과)
  • Sohn, Jung Heob (Department of Otorhinolaryngology-Head and Neck Surgery, Sanggye Paik Hospital, College of Medicine, Inje University) ;
  • Kim, Hyun-Jung (Department of Pathology, Sanggye Paik Hospital, College of Medicine, Inje University)
  • 투고 : 2018.09.13
  • 심사 : 2018.11.16
  • 발행 : 2018.12.30

⟨ 이전 논문 다음 논문 ⟩

초록

Pleomorphic liposarcoma is extremely rare in the head and neck region. It can be diagnosed by identifying multivacuolated lipoblast with pleomorphism. Most studies have reported that pleomorphic liposarcoma shows an aggressive behavior with poor prognosis. The treatment of choice is wide resection to ensure negative margin. The authors report a case of pleomorphic liposarcoma in a 67-year-old female, who was treated with primary resection of tumor and postoperative radiation therapy. The patient is well without any recurrence or metastasis after 1 year of follow-up.

키워드

참고문헌

  1. Hong HS, Kim TS, Cho HW, Eom JW. A case of primary myxoid liposarcoma of the neck. Korean J Otolaryngol 1999;42(11):1465-8.
  2. Hornick JL, Bosenberg MW, Mentzel T, McMenamin ME, Oliveira AM, Fletcher CD. Pleomorphic liposarcoma: clinicopathologic analysis of 57 cases. Am J Surg Pathol 2004;28(10):1257-67. https://doi.org/10.1097/01.pas.0000135524.73447.4a
  3. Khurana J, Mertens F, Boree Jr. Adipocytic tumors. In: Fletcher CD, Unni KK, Mertens F, editors. World Health Organization classification of tumors. Pathology and genetics of tumors of soft tissue and bone. Lyon: IARC press; 2002. p.35-46.
  4. Downes KA, Goldblum JR, Montgomery EA, Fisher C. Pleomorphic liposarcoma: a clinicopathologic analysis of 19 cases. Mod Pathol 2001;14:179-84. https://doi.org/10.1038/modpathol.3880280
  5. Gebhard S, Coindre JM, Michels JJ, Terrier P, Bertrand G, Trassard M, et al. Pleomorphic liposarcoma: clinicopathologic, immunohistochemical, and follow-up analysis of 63 cases. A study from the French Federation of Cancer Centers Sarcoma Group. Am J Surg Pathol 2002;26(5):601-16. https://doi.org/10.1097/00000478-200205000-00006
  6. Golledge J, Fisher C, Rhys-Evans PH Head and neck liposarcoma. Cancer 1995;76(6):1051-8. https://doi.org/10.1002/1097-0142(19950915)76:6<1051::AID-CNCR2820760620>3.0.CO;2-4
  7. Reitan JB, Kaalhus O, Brennhovd IO, Sager EM, Stenwiq AE, Talle K. Prognostic factors in liposarcoma: Cancer 1985;55(10):2482-90. https://doi.org/10.1002/1097-0142(19850515)55:10<2482::AID-CNCR2820551029>3.0.CO;2-R
  8. Wang L, Ren W, Zhou X, Sheng W, Wang J. Pleomorphic liposarcoma: a clinicopathological, immunohistochemical and molecularcytogenetic study of 32 additional cases. Pathol Int 2013;63(11):523-31. https://doi.org/10.1111/pin.12104
  9. Mertens F, Fletcher CDM, Dal Cin P, De Wever I, Mandahl N, Mitelman F, et al. Cytogenetic analysis of 46 pleomorphic soft tissue sarcomas and correlation with morphologic and clinical features: a report of the CHAMP study group. Genes Chromosomes Cancer 1998;22(1):16-25. https://doi.org/10.1002/(SICI)1098-2264(199805)22:1<16::AID-GCC3>3.0.CO;2-A
  10. Boland JM, Weiss SW, Oliveira AM, Erickson-Johnson ML, Folpe AL. Liposarcomas with mixed well-differentiated and pleomorphic features: a clinicopathologic study of 12 cases. Am J Surg Pathol 2010;34(6):837-43. https://doi.org/10.1097/PAS.0b013e3181dbf2f7
  11. Marino-Enriquez A, Fletcher CD, Dal Cin P, Hornick JL. Dedifferentiated liposarcoma with 'homologous' lipoblastic (pleomorphic liposarcoma-like) differentiation: clinicopathologic and molecular analysis of a series suggesting revised diagnostic criteria. Am J Surg Pathol 2010;34(8):1122-31. https://doi.org/10.1097/PAS.0b013e3181e5dc49
  12. Fletcher CDM. Pleomorphic malignant fibrous histiocytoma: fact or fiction? A critical reappraisal based on 159 tumors diagnosed as pleomorphic sarcoma. Am J Surg Pathol 1992;16(3):213-28. https://doi.org/10.1097/00000478-199203000-00001
  13. Shimada S, Ishizawa T, Ishizawa K, Matsumura T, Hasegawa T, Hirose T. The value of MDM2 and CDK4 amplification levels using real-time polymerase chain reaction for the differential diagnosis of liposarcomas and their histologic mimickers. Hum Pathol 2006;37(9):1123-9. https://doi.org/10.1016/j.humpath.2006.04.010
  14. Weaver J, Downs-Kelly E, Goldblum JR, Turner S, kulkarni S, Tubbs RR, et al. Fluorescence in situ hybridization for MDM2 gene amplification as a diagnostic tool in lipomatous neoplasms. Mod Pathol 2008;21(8):943-9. https://doi.org/10.1038/modpathol.2008.84
  15. Pearlstone D, Pisters PW, Bold RJ, Feig BW, Hunt KK, Yasko AW, et al. Patterns of recurrence in extremity liposarcoma: implications for staging and follow-up. Cancer. 1999;85(1):85-92. https://doi.org/10.1002/(SICI)1097-0142(19990101)85:1<85::AID-CNCR12>3.0.CO;2-A
  16. Chandan VS, Fung EK, Woods CI, de la Roza G. Primary pleomorphic liposarcoma of the parotid gland: a case report and review of the literature. Am J Otolaryngol 2004; 25(6):432-7. https://doi.org/10.1016/j.amjoto.2004.06.003
  17. Ham SJ, van der Graaf WT, Pras E, Molenaar WM, van den Berg E, Hoekstra HJ Soft tissue sarcoma of the extremities: a multimodality diagnostic and therapeutic approach. Cancer Treat Rev 1998;24(6):373-91. https://doi.org/10.1016/S0305-7372(98)90001-9
  18. Seynaeve C, Verweij J. High-dose chemotherapy in adult sarcomas: No standard yet. Semin Oncol 1999;26(1):119-13.