Journal of Clinical Otolaryngology Head and Neck Surgery (임상이비인후과)

The Busan, Ulsan, Gyeoungnam Branch of Korean Society of Otolaryngology-Head and Neck Surgery (대한이비인후과학회 부산,울산,경남 지부회)
권호 표지

A Case of Immunotherapy in Small Cell Type Malignant Melanoma of Nasal Cavity

비강 내 소세포형 악성 흑색종의 면역치료 1예

  • Kim, Chang Hoi (Department of Otolaryngology-Head and Neck Surgery, College of Medicine, Kosin University) ;
  • Kwon, Jae Hwan (Department of Otolaryngology-Head and Neck Surgery, College of Medicine, Kosin University) ;
  • Kim, Ju Yeon (Department of Otolaryngology-Head and Neck Surgery, College of Medicine, Kosin University)
  • 김창회 (고신대학교 의과대학 이비인후과학교실) ;
  • 권재환 (고신대학교 의과대학 이비인후과학교실) ;
  • 김주연 (고신대학교 의과대학 이비인후과학교실)
  • Received : 2018.09.13
  • Accepted : 2018.11.28
  • Published : 2018.12.30

⟨ Previous Next ⟩

Abstract

There are many treatment options for the malignant melanoma. Wide excisional surgery is one of the most acceptable treatments for locoregional treatment. Depending on the pathologic classification, however, some other treatment option can be included such as chemotherapy, radiotherapy and immunotherapy as adjuvant treatment. Small cell type malignant melanoma is a rare variant of malignant melanoma. It is known that melanomas manifesting this morphology are invariably in vertical growth phase and have an aggressive course. The authors encountered small cell type malignant melanoma and would like to share the experience of successful treatment with surgery plus immunotherapy as one of adjuvant treatment options.

Keywords

References

  1. Hong SL, Kim SW, Won TB, Shim WS, Kim YM, Kim JW, et al. Clinical Features and Treatment Outcomes of Mucosal Malignant Melanomas of Nasal Cavity and Paranasal Sinuses. Korean Journal of Otorhinolaryngology-Head and Neck Surgery 2006;49(12):1176-80.
  2. Chang AE, Karnell LH, Menck HR. The National Cancer Data Base report on cutaneous and noncutaneous melanoma: a summary of 84,836 cases from the past decade. Cancer: Interdisciplinary International Journal of the American Cancer Society 1998;83(8):1664-78.
  3. Banerjee SS, Harris M. Morphological and immunophenotypic variations in malignant melanoma. Histopathology 2000;36(5):387-402. https://doi.org/10.1046/j.1365-2559.2000.00894.x
  4. Lian B, Guo J. Adjuvant therapy of mucosal melanoma. Chinese Clinical Oncology 2014;3(3):33.
  5. Snow G, Van Esch ED, Van Slooten E. Mucosal melanomas of the head and neck. Head & Neck Surgery 1978;1(1):24-30. https://doi.org/10.1002/hed.2890010104
  6. Edge SB, Compton CC. The American Joint Committee on Cancer: the 7th edition of the AJCC cancer staging manual and the future of TNM. Annals of Surgical Oncology 2010;17(6):1471-4. https://doi.org/10.1245/s10434-010-0985-4
  7. Koivunen P, Back L, Pukkila M, Laranne J, Kinnunen I, Grenman R, et al. Accuracy of the current TNM classification in predicting survival in patients with sinonasal mucosal melanoma. The Laryngoscope 2012;122(8):1734-8. https://doi.org/10.1002/lary.23343
  8. Prasad ML, Patel S, Hoshaw-Woodard S, Stacy, Escrig, Margarita, Shah, Jatin P, et al. Prognostic factors for malignant melanoma of the squamous mucosa of the head and neck. The American Journal of Surgical Pathology 2002;26(7):883-92. https://doi.org/10.1097/00000478-200207000-00006
  9. Blessing K, Grant JJH, Sanders DSA, Kennedy MM, Husain A, Coburn P. Small cell malignant melanoma: a variant of naevoid melanoma. Clinicopathological features and histological differential diagnosis. Journal of Clinical Pathology. 2000;53(8):591-5. https://doi.org/10.1136/jcp.53.8.591
  10. Cocconi G, Bella M, Calabresi F, Tonato M, Canaletti R, Boni C, et al. Treatment of metastatic malignant melanoma with dacarbazine plus tamoxifen. New England Journal of Medicine 1992;327 (8):516-23. https://doi.org/10.1056/NEJM199208203270803
  11. Barth A, Morton DL. The role of adjuvant therapy in melanoma management. Cancer 1995;75(S2):726-34. https://doi.org/10.1002/1097-0142(19950115)75:2+<726::AID-CNCR2820751417>3.0.CO;2-R
  12. Garbe C, Peris K, Hauschild A, Hauschild A, Saiag P, Middleton M, et al. Diagnosis and treatment of melanoma: European consensus-based interdisciplinary guideline. European Journal of Cancer 2010;46(2):270-83. https://doi.org/10.1016/j.ejca.2009.10.032
  13. Coit DG, Thompson JA, Algazi A, Andtbacka R, Christopher K, Bichakjian, et al. Melanoma, version 2.2016, NCCN clinical practice guidelines in oncology. Journal of the National Comprehensive Cancer Network 2016;14(4):450-73. https://doi.org/10.6004/jnccn.2016.0051
  14. Verma S, Quirt I, McCready D, Bak K, Charette M, Iscoe N, et al. Systematic review of systemic adjuvant therapy for patients at high risk for recurrent melanoma. Cancer 2006;106(7):1431-42. https://doi.org/10.1002/cncr.21760
  15. Owens JM, Roberts DB, Myers JN. The role of postoperative adjuvant radiation therapy in the treatment of mucosal melanomas of the head and neck region. Archives of Otolaryngology-Head & Neck Surgery 2003;129(8):864-8. https://doi.org/10.1001/archotol.129.8.864
  16. 최병철 Issue& Trend 면역항암제; 2017. http://www.health.kr/Menu.PharmReview/_uploadfiles/%EB%A9%B4%EC%97%AD%ED%95%AD%EC%95%94%EC%A0%9C(Cancer%20Immunotherapy)%20(2).pdf. Accessed 2018.07.31.