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Effects of Bicycle Exercise on Inflammation Related Factor and Growth Hormone in Obese Middle aged Women

자전거 운동이 비만 중년여성의 염증관련인자 및 성장호르몬에 미치는 영향

  • 김종혁 (중원대학교 뷰티헬스학과)
  • Received : 2018.08.16
  • Accepted : 2018.10.20
  • Published : 2018.10.28

Abstract

The purpose of this study was to identify the effects of bicycling exercise by analyzing the changes of inflammation-related factors and growth hormone with obese middle-aged women for 8 weeks to identify the effects of bicycle exercise. In this study, 15 middle aged obese women were divided into exercise group and control group. Changes in inflammation-related factors and growth hormone were analyzed as a measurement variable were analyzed by employing two-way ANOVA with repeated measures. This study finds that $TNF-{\alpha}$ and IL-6 were significantly decreased in the exercise group and increased in the control group. Growth hormone was increased in the exercise group but not in the control group. The results of this study suggest that bicycling exercise is an exercise program to prevent cardiovascular and chronic diseases of obese middle-aged women.

본 연구는 비만 중년여성을 대상으로 8주간 자전거 운동을 통한 염증관련인자와 성장호르몬의 변화를 분석함으로써 자전거 운동의 효과를 규명하고 효율적인 운동을 위한 과학적 근거를 제시하는데 그 목적이 있다. 15명의 비만 중년 여성들은 자전거 운동군과 통제군으로 구분하여 8주간 주당 3회 60분간 자전거를 이용한 유산소 운동 프로그램을 실시하였다. 측정변인으로는 염증관련인자와 성장호르몬의 변화를 분석하였으며 통계처리는 이원 반복측정 분산분석(two-way ANOVA with repeated measure)을 실시하였다. 분석 결과 염증관련인자는에서 $TNF-{\alpha}$ 및 IL-6는 운동군에서 유의한 감소를 보였으며 통제군에서 증가하였다. 성장호르몬은 운동군에서 증가하였으나 유의한 차이가 나타나지 않았으며 통제군에서 감소하였다. 이와 같은 결과는 본 연구에서 실시한 자전거 운동이 비만 중년여성들의 심혈관계 및 만성질환을 예방 할 수 있는 운동 프로그램이라고 사료된다.

Keywords

References

  1. Haydari F, Mohammadkhan Keshavarz S, Vanaki Z & Kazemnejad A. (2011). A Survey the effect of planned program of health promotion on stress management in middle-aged women (In Persian). Iranian Journal of Nursing Research, 6(22), 16-22.
  2. Azh N & Danesh M. (2012). Effect of education on middle aged women on premenopausal side effect. Zahedan Journal of Research in Medical Sciences, 13(1), 12.
  3. Kase N. G. (2009). Impact of hormone therapy for women aged 35 to 65 years, from contraception to hormone replacement. Gender Medicine, 6(1), 37-59. https://doi.org/10.1016/j.genm.2009.02.001
  4. Zahedi M & Deris F. (2014). The quality of life in pregnant women in Farokhshahr city (In Persian). Journal of Clinical Nursing and Midwifery, 3(3), 63-69.
  5. Keshavarz Z, Simbar M & Ramezankhani A. (2014). The impact of educational interventions based on "integrated model of planned behavior and self-efficacy" on health promotion behaviors of female workers in reproductive age (In Persian). Knowledge and Health, 9(3), 54-61.
  6. Lee T. W, Ko I. S & Lee K. J. (2006). Health promotion behaviors and quality of life among community-dwelling elderly in Korea: a cross-sectional survey. International Journal of Nursing Studies, 43(3), 293-300. https://doi.org/10.1016/j.ijnurstu.2005.06.009
  7. Rafiee A, Doostifar K & Tavasoli E. (2013). The lifestyle of married women referring to health centers in West of Ahvaz. Journal of Ilam University of Medical Sciences, 22(3), 1-9.
  8. Leitão M. B, Lazzoli J. K, Oliveira M. A. B, Nóbrega A. C. L, Silveira G. G, Carvalho T, Fernandes E. O, Leite N, Ayub A. V, Michels G, Drummond F. A, Magni J. R. T, Macedo C & De Rose E. H. (2000). Posicionamento Oficial da Sociedade Brasileira de Medicina do Esporte: Atividade Física e Saude na Mulher. Revista brasileira de medicina do esporte, 6(6), 215-220. https://doi.org/10.1590/S1517-86922000000600001
  9. Lee I. M, Shiroma E. J, Lobelo F, Puska P, Blair S. N & Katzmarzyk P. T. (2012). Effect of physical inactivity on major non-communicable diseases worldwide: an analysis of burden of disease and life expectancy. Lancet, 380(9838), 219-229. https://doi.org/10.1016/S0140-6736(12)61031-9
  10. Miles L. (2007). Physical activity and health. Nutrition Bulletin, 32(4), 314-63. https://doi.org/10.1111/j.1467-3010.2007.00668.x
  11. Nelson M. E, Rejeski W. J, Blair S. N, Duncan P. W, Judge J. O, King A. C, Macera C. A & Castaneda-Sceppa C. (2007). Physical Activity and public health in older adults: recommendation from the American Heart from the American College of Sport Medicine and the American Heart Association. Circulation, 116(9), 1094-1195. https://doi.org/10.1161/CIRCULATIONAHA.107.185650
  12. Dinas P. C, Koutedakis Y & Flouris A. D. (2011). Effects of exercise and physical activity on depression. Irish Journal of Medical Science, 180(2), 319-325. https://doi.org/10.1007/s11845-010-0633-9
  13. Schulz K. H, Meyer A & Langguth N. (2012). Exercise and psychological well-being. Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz, 55(1), 55-65. https://doi.org/10.1007/s00103-011-1387-x
  14. Oja P, Titze S, Bauman A, de Geus B, Krenn P, Reger-Nash B & Kohlberger T. (2011). Health benefits of cycling: a systematic review. Scandinavian Journal Of Medicine & Science In Sports, 21(4), 496-509. https://doi.org/10.1111/j.1600-0838.2011.01299.x
  15. Engbers L. H & Hendriksen I. J. (2010). Characteristics of a population of commuter cyclists in the Netherlands: perceived barriers and facilitators in the personal, social and physical environment. The international journal of behavioral nutrition and physical activity, 7, 89. https://doi.org/10.1186/1479-5868-7-89
  16. Garrard J, Crawford S & Hakman N. (2006). Revolutions for Women: Increasing Women's Participation in Cycling for Recreation and Transport. Melbourne: Deakin University.
  17. Bonham J & Koth B. (2010). Universities and the cycling culture. Transportation Research Part D: Transport and Environment, 15(2), 94-102. https://doi.org/10.1016/j.trd.2009.09.006
  18. Oja P, Titze S, Bauman A, de Geus B, Krenn P, Reger-Nash B & Kohlberger T. (2011). Health benefits of cycling: a systematic review. Scandinavian Journal of Medicine and Science in Sports, 21(4), 496-509. https://doi.org/10.1111/j.1600-0838.2011.01299.x
  19. Maachi M, Piéroni L, Bruckert E, Jardel C, Fellahi S, Hainque B, Capeau J & Bastard J. P. (2004). Systemic low-grade inflammation is related to both circulating and adipose tissue TNF alpha, leptin and IL-6 levels in obese women. International journal of obesity and related metabolic disorders, 28(8), 993-997. https://doi.org/10.1038/sj.ijo.0802718
  20. Denollet J, Conraads V. M, Brutsaert D. L, De Clerck L. S, Stevens W. J & Vrints C. J. (2003). Cytokines and immune activation in systolic heart failure: the role of Type D personality. Brain, behavior, and immunity, 17(4), 304-309. https://doi.org/10.1016/S0889-1591(03)00060-6
  21. Pedersen S. S & Denollet J. (2004). Validity of the Type D personality construct in Danish post-MI patients and healthy controls. Journal of psychosomatic research, 57(3), 265-272. https://doi.org/10.1016/S0022-3999(03)00614-7
  22. Weaver J. U, Monson J. P, Noonan K, John W. G, Edwards A, Evans K. A & Cunningham J. (1995). The effect of low dose recombinant human growth hormone replacement on regional fat distribution, insulin sensitivity, and cardiovascular risk factors in hypopituitary adults. The Journal of clinical endocrinology and metabolism, 80(1), 153-159. https://doi.org/10.1210/jc.80.1.153
  23. Jung H. J & Oh J. K. (2007). The effect of cycling exercise on serum IGF-I, body composition, and BMD in peri-menopausal women. Korea Sport Research, 18(4), 397-406.
  24. Ko SK. (2004). The ischemic cardiac symptom during the treadmill exercise in the adolescent cycle athletes. Korea Sport Research, 15(1), 1191-1200.
  25. Kim K. A, Choi H. M, Nho H. S & Kim J. K. (2011). Cardiovascular Responses During Graded Cycling Exercise in Postmenopausal Women. Korean Journal of Physical Education, 50(3), 603-609.
  26. Min B. I, Jo H. B & Choi S. R. (2003). Effect of obese woman student in bicycle exercise. Korea Sport Research, 14(4), 1297-1308.
  27. Lee M. S & Nho H. S. (2005). Characteristics of lipid metabolism during and after a bout of prolonged exercise in two types of obese women. Korean Journal of Sport Science, 16(2), 64-73.
  28. Lee H. Y. (2012). Effect of resistance muscle exercise and bicycle exercise on blood pressure and body COG(Center of Gravity) in hypertensive patients with women's. Korean Journal of Physical Education, 51(4), 489-495.
  29. Ko S. K. (2002). The effects of bicycle exercise on blood composition, cardiorespiratory function and leg muscle power in male adolescence. Journal of Sport and Leisure Studies, 17, 643-652.
  30. Park D. S & Chun S. Y. (2015). Effect of unicycle exercise on body composition, physical fitness and isokinetic strength of knee joint in male university students. Journal of Sport and Leisure Studies, 60, 739-748.
  31. Borrestad L. A, Ostergaard L, Andersen L. B & Bere E. (2012). Experiences from a randomized, controlled trial on cycling to school: Does cycling increase cardiorespiratory fitness?. Scandinavian journal of public health, 40(3), 245-252. https://doi.org/10.1177/1403494812443606
  32. Lusk A, Mekary R, Feskanich D & Willett, W. (2010). Bicycle riding, walking, and weight gain in premenopausal women. Archives of Internal Medicine, 170(12), 1050-1056. https://doi.org/10.1001/archinternmed.2010.171
  33. Pucher J, Buehler R & Seinen M. (2011). Bicycling renaissance in North America? An update and reappraisal of cycling trends and policies. Transportation Research Part A: Policy and Practice, 45(6), 451-457. https://doi.org/10.1016/j.tra.2011.03.001
  34. Huy C, Becker S, Gomolinsky U, Klein T & Thiel, A. (2008). Health, medical risk factors, and bicycle use in everyday life in the over-50 population. Journal of aging and physical activity, 16(4), 454-464. https://doi.org/10.1123/japa.16.4.454
  35. Lauwerys B. R & Houssiau F. A. (2003). Involvement of cytokines in the pathogenesis of systemic lupus erythematosus. Advances in Experimental Medicine and Biology, 520, 237-251.
  36. Tackey E, Lipsky P. E & Illei G. G. (2004). Rationale for interleukin-6 blockade in systemic lupus erythematosus. Lupus, 13(5), 339-343. https://doi.org/10.1191/0961203304lu1023oa
  37. Lee D. H, O. h D. H, Zhang S. A & Lee J. K. (2016). Effect of exercise type and intensity on insulin resistance and cardiovascular disease risk factors in obese middle aged women. Journal of the Korea Academia-Industrial cooperation Society, 17(6), 181-191. https://doi.org/10.5762/KAIS.2016.17.6.181
  38. Park M. S, Zang S. A & Lee J. K. (2017). Effect of 4 Weeks' Walking Exercise with Blood Flow Restriction on Inflammatory index, Isokinetic Muscle Function, and Thigh Circumference in Obese Women. Journal of the Korea Academia-Industrial cooperation Society, 18(10), 480-489. https://doi.org/10.5762/KAIS.2017.18.10.480
  39. Kim D. H & Kang H. S. (2015). The Effects of Cardio Tennis Program for 10 Weeks on Cardiovascular Disease Risk Factors, Inflammatory markers and Aerobic Capacity in Middle-Age Females. The Korea Journal of Sports Science, 24(6), 1127-1141.
  40. Joo H. C & Yang S. W. (2015). The Effect of Combined Exercise Program on Body Shape, Health-Related Physical Fitness, and Inflammatory Markers in Postmenopausal Obese Middle-Aged Women. The Korean Journal of Sport, 13(2), 403-412.
  41. Ko K. K, Seon B. S & Kang S. J. (2015). Effects of Exercise Intensity on Inflammatory Response Index and Insulin Resistance in Obese Middle-aged Women. The Asian Journal of Kinesiology, 17(2), 49-56.
  42. Peake J. M, Suzuki K, Wilson G, Hordern M, Nosaka K, Mackinnon L & Coombes J. S. (2005). Exercise-induced muscle damage, plasma cytokines, and markers of neutrophil activation. Medicine & Science in Sports & Exercise, 37(5), 737-345. https://doi.org/10.1249/01.MSS.0000161804.05399.3B
  43. Tomiya A, Aizawa T, Nagatomi R, Sensui H & Kokubun S. (2004). Myofibers express IL-6 after eccentric exercise. The American Journal of Sports Medicine, 32(2), 503-508. https://doi.org/10.1177/0095399703258788
  44. Filteau S. M, Menzies R. A, Kaido T. J, O’Grady M. P, Gelderd J. B & Hall N. R. (1992). Effects of exercise on immune functions of undernourished mice. Life Sciences, 51(8), 565-574. https://doi.org/10.1016/0024-3205(92)90225-E
  45. Shepard R. J & Shek P. N. (1997). Autoimmune disorders, physical activity, and training, with particular reference to rheumatoid arthritis. Exercise Immunology Review, 3, 53-67.
  46. Nicklas B. J, You T & Pahor M. (2005). Behavioral treatments for chronic systemic inflammation: effects of dietary weight loss and exercise training. Canadian Medical Association Journal, 172(9), 1199-209. https://doi.org/10.1503/cmaj.1040769
  47. Vijayaraghava A, Doreswamy V, Narasipur O. S, Kunnavil R & Srinivasamurthy N. (2015). Effect of yoga practice on levels of inflammatory markers after moderate and strenuous exercise. Journal of Clinical and Diagnostic Research, 9(6), CC08-12.
  48. Newsholme E. A & Leech A. R. (2010). Functional biochemistry in health and disease. 1st Ed. Oxford: John Wiley and Sons.
  49. Lee J. K. (2017). Effect of Walking Exercise with Blood Flow Restriction on Body Composition, Growth Hormone, and Muscle Damage Markers in Obese Women. Journal of the Korea Academia-Industrial cooperation Society, 18(4), 183-190. https://doi.org/10.5762/KAIS.2017.18.4.183
  50. Kim C. H & Lee H. W. (2016). The Effects of Trunk Stabilization Exercise Program on Serum Density of Lipids, GH, Pelvic Tilt Angle for Middle Aged Obese Women. The Journal of Korea Society for Wellness, 11(4), 499-509. https://doi.org/10.21097/ksw.2016.11.11.4.499
  51. Baek S. K & Min Y. S. (2015). Effects of Using Digital Content for High-Intensity Interval Exercise on Growth Hormone and fatigue Elements in Middle Aged Women. Journal of Digital Convergence, 13(9), 523-530. https://doi.org/10.14400/JDC.2015.13.9.523
  52. Sung, J. M, Bang G. H., Kong M. A., Kim J. S & Kang H. S. (2012). The effects of aerobic exercise on blood lip ids, s tress and growth hormones of middle-aged women based on NaB golf training. Exercise Science, 21(4), 445-454. https://doi.org/10.15857/ksep.2012.21.4.445
  53. Yeo N. H, Oh K. S, Cha Y. R & Kang S. H. (2008). Effect of Yoga Exercise Program on Catecholamine and Growth Hormone in Pre and Postmenopausal Middle Aged Women. Korean Journal of Sport Science, 19(1), 31-40.
  54. Kim. H. J. Kim. J. W & Park G. H. (2007). The effects of aquatic exercise program on obese index, growth hormone, igf-1 and vas in obese women with osteoarthritis of the knee. Korean journal of physical education, 46(4), 579-591.
  55. Felsing N. E., Brasel J. A & Cooper D. M. (1992). Effect of low and high intensity exercise on circulating growth hormone in men. The Journal of Clinical Endocrinology & Metabolism, 75(1), 157-162. https://doi.org/10.1210/jc.75.1.157
  56. Reinehr. T. De Sousa G & Roth. C. L. (2008). Obestatin and ghrelin levels in obese children and adolescents before and after reduction of overweight. Clinical endocrinology, 68(2), 304-310. https://doi.org/10.1111/j.1365-2265.2007.03042.x