Nutrition Research and Practice

The Korean Nutrition Society (한국영양학회)
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Corni Fructus attenuates testosterone-induced benign prostatic hyperplasia by suppressing 5α-reductase and androgen receptor expression in rats

  • Hwangbo, Hyun (Anti-Aging Research Center, Dongeui University) ;
  • Kwon, Da He (Anti-Aging Research Center, Dongeui University) ;
  • Choi, Eun Ok (Anti-Aging Research Center, Dongeui University) ;
  • Kim, Min Yeong (Anti-Aging Research Center, Dongeui University) ;
  • Ahn, Kyu Im (Anti-Aging Research Center, Dongeui University) ;
  • Ji, Seon Yeong (Anti-Aging Research Center, Dongeui University) ;
  • Kim, Jong Sik (Department of Anatomy, Kosin University College of Medicine) ;
  • Kim, Kyung-Il (Gurye Sansooyu Farming Association Corporation) ;
  • Park, No-Jin (Gurye-gun Agricultural Center) ;
  • Kim, Bum Hoi (Department of Anatomy, Dongeui University College of Korean Medicine) ;
  • Kim, Gi-Young (Laboratory of Immunobiology, Department of Marine Life Sciences, Jeju National University) ;
  • Hong, Su-Hyun (Anti-Aging Research Center, Dongeui University) ;
  • Park, Cheol (Department of Molecular Biology, College of Natural Sciences, Dongeui University) ;
  • Jeong, Ji-Suk (Gurye-gun Agricultural Center) ;
  • Choi, Yung Hyun (Anti-Aging Research Center, Dongeui University)
  • Received : 2018.02.05
  • Accepted : 2018.06.19
  • Published : 2018.10.01
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Abstract

BACKGROUND/OBJECTIVES: Benign prostatic hypertrophy (BPH) is a major cause of abnormal overgrowth of the prostate mainly in the elderly. Corni Fructus has been reported to be effective in the prevention and treatment of various diseases because of its strong antioxidant effect, but its efficacy against BPH is not yet known. This study was designed to evaluate the therapeutic efficacy of Corni Fructus water extract (CF) in testosterone-induced BPH rats. MATERIALS/METHODS: To induce BPH, rats were intraperitoneal injected with testosterone propionate (TP). Rats in the treatment group were orally administered with CF with TP injection, and finasteride, which is a selective inhibitor of $5{\alpha}$-reductase type 2, was used as a positive control. RESULTS: Our results showed that the increased prostate weight and histopathological changes in BPH model rats were suppressed by CF treatment. CF, similar to the finasteride-treated group, decreased the levels of testosterone and dihydrotestosterone by TP treatment in the serum, and it also reduced $5{\alpha}$-reductase expression and concentration in prostate tissue and serum, respectively. In addition, CF significantly blocked the expression of the androgen receptor (AR), AR co-activators, and proliferating cell nuclear antigen in BPH rats, and this blocking was associated with a decrease in prostate-specific antigen levels in serum and prostate tissue. CONCLUSIONS: These results suggest that CF may weaken the BPH status through the inactivation of at least $5{\alpha}$-reductase and AR activity and may be useful for the clinical treatment of BPH.

Keywords

References

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