Journal of Preventive Veterinary Medicine

The Korean Society of Preventive Veterinary Medicine (한국예방수의학회)
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Toxicity of a combination of florfrenicol and acetaminophen in pigs administered at overdose

  • Chae, Won-Seok (Schools of Life-Chemistry, Daejin University) ;
  • Yoo, Chang-Yeul (Department of Computer Software Science, Gyeongnam Provincial Namhae College) ;
  • Tutkun, Lutfiye (Department of Medical Biochemistry, Bozok University) ;
  • Kim, Suk (Institute of Animal Medicine, College of Veterinary Medicine, Gyeongsang National University) ;
  • Lee, Hu-Jang (Institute of Animal Medicine, College of Veterinary Medicine, Gyeongsang National University)
  • Received : 2018.10.17
  • Accepted : 2018.12.07
  • Published : 2018.12.31
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Abstract

This study examined the overdose toxicity of Super-Neophensan, containing florfenicol and acetaminophen, upon pigs. SNP-3.0 (n=10) was administered at the dosage level of 3 kg/ton feed for 7 consecutive days, which is 3 times the recommended dose based on the guidelines of the manufacturer, and the control group (CON) (n=10) was administered the normal diet without the drug. The body weight, weight gain and feed efficiency in SNP-3.0 treated with the drug for 14 days post-administration showed no significant differences compared with those in CON. In hematological and blood biochemical analyses, all parameters were not affected by over-dosage of the drug. In the same way, there were no significant differences between SNP-3.0 and CON on markers for liver and kidney functions. As no adverse effects were observed with the drug in an overdose oral toxicity test, this study suggests that the drug was identified as a safe agent in pigs administered with three times the recommended dose.

Keywords

Acknowledgement

Supported by : Dae Han New Pharm Co., LTD.

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