Molecules and Cells

Korean Society for Molecular and Cellular Biology (한국분자세포생물학회)
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Structural Basis for LAR-RPTP-Mediated Synaptogenesis

  • Won, Seoung Youn (Department of Chemistry, Korea Advanced Institute of Science and Technology (KAIST)) ;
  • Kim, Ho Min (Graduate School of Medical Science & Engineering, Korea Advanced Institute of Science and Technology (KAIST))
  • Received : 2018.05.10
  • Accepted : 2018.06.25
  • Published : 2018.07.31
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Abstract

Leukocyte common antigen-related protein tyrosine phosphatases (LAR-RPTPs) are cellular receptors of heparan sulfate (HS) and chondroitin sulfate (CS) proteoglycans that regulate neurite outgrowth and neuronal regeneration. LAR-RPTPs have also received particular attention as the major presynaptic hubs for synapse organization through selective binding to numerous postsynaptic adhesion partners. Recent structural studies on LAR-RPTP-mediated trans-synaptic adhesion complexes have provided significant insight into the molecular basis of their specific interactions, the key codes for their selective binding, as well as the higher-order clustering of LAR-RPTPs necessary for synaptogenic activity. In this review, we summarize the structures of LAR-RPTPs in complex with various postsynaptic adhesion partners and discuss the molecular mechanisms underlying LAR-RPTP-mediated synaptogenesis.

Keywords

References

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