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A Case of Synchronous Lung Squamous Cell Carcinoma and Diffuse Large B-cell Lymphoma

동시성으로 발생한 폐 편평세포암종과 흉곽내 광범위큰B세포림프종 1예

  • Lee, Seung Jae (Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine) ;
  • Lim, Si Young (Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine) ;
  • Yoo, Tae Kyung (Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine) ;
  • Kim, Seul Ki (Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine) ;
  • Kim, You Gyung (Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine) ;
  • Lee, Hyun Joo (Department of Pathology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine) ;
  • Song, Jae Uk (Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine)
  • 이승재 (성균관대학교 의과대학 강북삼성병원 내과) ;
  • 임시영 (성균관대학교 의과대학 강북삼성병원 호흡기내과) ;
  • 유태경 (성균관대학교 의과대학 강북삼성병원 내과) ;
  • 김슬기 (성균관대학교 의과대학 강북삼성병원 내과) ;
  • 김유경 (성균관대학교 의과대학 강북삼성병원 내과) ;
  • 이현주 (성균관대학교 의과대학 강북삼성병원 병리과) ;
  • 송재욱 (성균관대학교 의과대학 강북삼성병원 호흡기내과)
  • Received : 2017.05.23
  • Accepted : 2017.11.08
  • Published : 2018.06.01

Abstract

A 65-year-old male was referred to our hospital for evaluation of a right pleural effusion. Thoracic computed tomography (CT) revealed a huge central mass with right hilar and subcarinal lymph node conglomerates. An endobronchial mass was incidentally found in the right upper lobe bronchus, and endobronchial ultrasound-guided transbronchial needle biopsy of the mediastinal lymph nodes was thus also performed at the time of bronchoscopy. The two biopsies revealed squamous cell carcinoma and diffuse large B-cell lymphoma (DLBCL), respectively. As the pathology of the mediastinal lymph nodes was unknown, the lung cancer could not be accurately staged. Thus, we treated the DLBCL; follow-up positron emission tomography/CT after two cycles of chemotherapy showed that the conglomerate mass had disappeared but the right upper lobe lesion remained. Lung cancer staging thus became more accurate and radical treatment could be considered. To the best of our knowledge, this is the first report of a co-existing squamous cell carcinoma of the lung and DLBCL of the intrapulmonary lymph nodes.

동시성 다발성 중복암의 경우 각각의 암종별 병기 설정과 치료 계획을 결정하기 어려운 경우가 많다. 특히 폐암과 비호지킨림프종 모두 종격동과 폐문 림프절을 침범할 수 있기 때문에, 이 두 암종이 동시에 공존하는 경우는 폐암의 병기를 결정 짓기 어렵다. 본 증례는 국내에서 동시성으로 발생한 편평상피세포 폐암과 종격동 림프종을 진단한 첫 번째 보고로써, 조직학적 확인의 중요성과 동시 다발성 중복암의 가능성을 간과해서는 안됨을 제시하고 있다. 이에 저자들은 우측 흉수를 주소로 내원한 65세 남자에서 기관지경 생검 및 초음파 유도하 경기관지 세침흡인술을 통해 폐의 편평세포 암종과 흉곽의 광범위큰B세포림프종이 동시성으로 발생한 중복암을 진단한 1예를 문헌고찰과 함께 보고하는 바이다.

Keywords

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