The Pharmacognosical Study on the Citrus Fruit Peels cultivated in Jeju Island by Chemotaxonomy

성분분류학적 방법에 의한 제주도산 감귤류 과피의 생약학적 연구

  • Received : 2018.04.16
  • Accepted : 2018.05.10
  • Published : 2018.06.30

Abstract

The application of 112 samples of Citrus fruit peel, which is commonly cultivated in Korea as crude drug, has been limited due to the absence of criteria concerning chemical constituents and application of itself. In the context, this study is on the analysis of 11 flavonoid compounds. As a result, the flavonoid pattern could be classified into 5 groups. Furthermore, by utilizing this HPLC data, this study could provide a basis for fruit peel applications of not only Citrus unshiu, but also its cultivars, hybrids and some of Citrus plants which has been cultivated in Jeju Island for a long time. Moondan could be used for the same purposes as Chinese Huajuhong, and Poncirus trifoliata of Korean Jisil origin are effective enough, in terms of ingredients and function, compared with C. aurantium. Based on the content and composition of the PMF region in this study, C. unshiu and C. reticulata, as Tanaka System shows, should be considered as different hortcultural speicies. Also, Jikak, which is known as 'sour orange' until now, is confirmed as Chosen-daidai, C. tenuissima, that was reported by Tanaka in 1970, and this C. tenuissima could be used for the same purposes as sour orange.

Keywords

References

  1. Engler, A. (1931) Rutaceae. In Engler, A. and Pratl K. (ed), Die Naturlichen Pflanzenfamilien, 187-359. Engelmann, Leipzig.
  2. Swingle, W. T. (1943) The botany of Citrus and its wild relatives. In Reuther, W., Webber, H. J. and Batchelor, L. D. (ed.), The Citrus Industry, 190-430. Univ. Calif. Washington D. C.
  3. Tanaka, T. (1969) Misunderstanding with Regards Citrus Classification and Nomenclature. Bull. Univ. Osaka Pref., Ser. B. 21: 133-145.
  4. Hodgson. R. W. (1961) Taxonomy and Nomenclature in Citrus. Proceedings of IOCV 2: 1-7.
  5. Albach, R. F. and Redman, G. H. (1969) Composition and inheritance of flavanones in citrus fruit. Phytochemistry 8: 127-143. https://doi.org/10.1016/S0031-9422(00)85805-7
  6. 國家藥典委員會 (2015) 中華人民共和國藥典 2015年版, 中國醫藥科技出版社, 北京.
  7. 식품의약품안전처 (2014) 대한민국약전 제11개정, 약업신문사, 서울.
  8. 厚生勞働省 (2016) 第17改正 日本藥局方. (株)廣川書店, 東京.
  9. Kefford, J. E. (1960) The chemical constituents of Citrus fruits. Adv. Food Res. 9: 285-372.
  10. Horowitz, R. M. (1961) Its biochemistry and physiology. In Sinclair W. B.(ed.), The Orange, 334-372. Univ. Calif. Washington D. C.
  11. Nishiura, M., Kamiya, S. and Esaki, S. (1969) Flavonoids in Citrus and related genera. Part I. Agr. Biol. Chem. 33: 1109-1118.
  12. Nishiura, M., Kamiya, S. and Esaki, S. (1971) Flavonoids in Citrus and related genera. Part III. Agr. Biol. Chem. 35: 1691-1706. https://doi.org/10.1271/bbb1961.35.1691
  13. Kamiya, S. and Esaki, S. (1971) Recent advances in the chemistry of the Citrus flavonoids. J. Food Sci. Tech. 18: 38-49. https://doi.org/10.3136/nskkk1962.18.38
  14. Pieringer, A. P., Edwards, G. J. and Wolford, R. W. (1964) Application of gas-liquid chromatography to the citrus leaf oils for the identification of kinds of citrus, Proc. Am. Soc. Hort. Sci. 84: 199-203.
  15. Scora, R. W. and Torrisi, S. (1966) Relation of taxonomic, climatic and tissue maturity factors to the essential oil constituents in leaves and fruits in Aurantioidae. Proc. Am. Soc. Hort. Sci. 88: 262-271.
  16. Macleod, W. D., Mcfadden, W. H. and Buiques, N. M. (1966), Lemon oil analysis. II. Gas-liquid chromatography on a temperature programmed long, open tubular column. J. Food. Sci. 31: 591-594. https://doi.org/10.1111/j.1365-2621.1966.tb01910.x
  17. Macleod, W. D. (1968) Lemon oil analysis. III. Rapid, capillary gas chromatography with combined flow and temperature programming. J. Food. Sci. 33: 436-437. https://doi.org/10.1111/j.1365-2621.1968.tb03646.x
  18. Ko, W. J, Huh, I. O. and Kim, C. M. (1982) 제주도산 감귤속 식물의 성분분류학적 연구. 한국식물학회지 25: 9-19.
  19. Mizuno, M., Iinuma, M., Ohara, M, Tanaka, T. and Iwamase, M. (1991) Chemotaxonomy of the genus Citrus based on polymethoxyflavones. Chem. Pharm. Bull. 39: 945-949. https://doi.org/10.1248/cpb.39.945
  20. Nogata, Y., Sakamoto, K., Shiratsuchi, H., Ishii, T., Yano, M. and Ohta, H. (2006) Flavonoid composition of fruit tissues of Citrus Species. Biosci. Biotech. Biochem. 70: 178-192. https://doi.org/10.1271/bbb.70.178
  21. Kim, H. G., Kim, G. S., Park, S., Lee, J. H., Seo, O. N., Lee, S. J., Kim, J. H., Shim, J. H., El-Aty, A. M. Abd, Jin, J. S. and Shin, S. C. (2011) Flavonoid profiling in three citrus varieties native to the Republic of Korea using liquid chromatography coupled with tandem mass spectrometry contribution to overall antioxidant activity. Biomed. Chromatogr. 26: 464-470.
  22. Yu, E. A., Kim, H. G., Song, Y., Kim, G., Kim, J. H., Kim, D. Y., Jin, J. S., Lee, S. J., Sung, N. J. and Shin, S. C. (2014) Determination of flavonoids in the peel of Jingyul (Citrus sunki Hort. ex Tanaka) using a HPLC-MS/MS and the antioxidant activity. Journal of Agriculture & Life Science 48: 227-234. https://doi.org/10.14397/jals.2014.48.3.227
  23. Kim, Y. D., Ko, W. J., Koh, K. S., Jeon, Y. J. and Kim, S. H. (2009). Composition of flavonoids and antioxidative activity from juice of Jeju native Citrus fruits during maturation. Korean J. Nutr. 42: 278-290. https://doi.org/10.4163/kjn.2009.42.3.278
  24. Rhyu, M., Kim, E. Y., Bae, I. Y. and Park, Y. K. (2002) Contents of naringin, hesperidin and neohesperidin in premature Korean Citrus fruits. Korean. J. Food Sci. Technol. 34: 132 - 135.
  25. Tanaka, Yu. (1980) 日本柑橘圖譜, 47, 150, 156, 473. 養賢堂, 東京
  26. Imai, A., Nesumi, H., Tanimonto, E., Moon, Y. E., Lee, D. H. K. and Kim, S. (2008) Collaborative exploration of Citrus genetic resources in south Korea. 植探報 24: 139-145.
  27. Hyun, J. M., Park, K. J., Kim, S. S., Park, S. M., Lee, Y. J. and An, H. J. (2015) Antioxidant and anti-inflammatory effects of solvent fractions from the pee of the native Jeju Citrus "Hongkyool" and "Pyunkyuool", J. Life Sci. 25: 1132-1138. https://doi.org/10.5352/JLS.2015.25.10.1132
  28. Wu, G. A., Terol, J., Ibanez, V., Lopez-Garcia, A., Perez-Roman, E., Borreda, C., Domingo, C., Tadeo, F. R., Carbonell-Caballero, J., Alonso, R., Curk, F., Du, D., Ollitrault, P., Roose, M. L., Dopazo, J., Gmitter Jr, F. G., Rokhsar, D. and Talon, M. (2018) Genomics of the origin and evolution of Citrus. Nature 554: 311-316. https://doi.org/10.1038/nature25447
  29. Braidy, N., Behzad, S., Habtemariam, S., Ahmed, T., Daglia, M., Nabavi, S. M., Sobarzo-Sanchez, E. and Nabavi, S. F. (2017) Neuroprotective effects of Citrus fruit-derived flavonoids, nobiletin and tangeretin in Alzheimer's and Parkinson's disease. Drug Targets 16: 1-11. https://doi.org/10.2174/187152731601170111213508