The Journal of Korean Medicine (대한한의학회지)

The Society of Korean Medicine (대한한의학회)
권호 표지
DOI QR코드

DOI QR Code

Case Report on Long Term Survival of Glioblastoma Patient Treated with Integrative Medicine

한양방결합치료로 장기간 생존하고 있는 교모세포종 증례 보고

  • Yang, Juno (Kyungheeyedang Oriental Medical Clinic) ;
  • Yun, Youngju (School of Korean Medicine, Pusan National University) ;
  • Hong, Jinwoo (School of Korean Medicine, Pusan National University) ;
  • Han, Changwoo (School of Korean Medicine, Pusan National University) ;
  • Kwon, Jungnam (School of Korean Medicine, Pusan National University) ;
  • Lee, In (School of Korean Medicine, Pusan National University) ;
  • Park, Seongha (School of Korean Medicine, Pusan National University) ;
  • Kim, Soyeon (School of Korean Medicine, Pusan National University) ;
  • Choi, Junyong (School of Korean Medicine, Pusan National University) ;
  • Lee, Hyeyoon (School of Korean Medicine, Pusan National University)
  • 양주노 (경희예당한의원) ;
  • 윤영주 (부산대학교 한의학전문대학원) ;
  • 홍진우 (부산대학교 한의학전문대학원) ;
  • 한창우 (부산대학교 한의학전문대학원) ;
  • 권정남 (부산대학교 한의학전문대학원) ;
  • 이인 (부산대학교 한의학전문대학원) ;
  • 박성하 (부산대학교 한의학전문대학원) ;
  • 김소연 (부산대학교 한의학전문대학원) ;
  • 최준용 (부산대학교 한의학전문대학원) ;
  • 이혜윤 (부산대학교 한의학전문대학원)
  • Received : 2017.12.29
  • Accepted : 2018.03.12
  • Published : 2018.03.31
Download PDF
⟨ Previous Next ⟩

Abstract

Objectives: This is a long-term survival case report about glioblastoma treated with western medicine and traditional Korean medicine. 28 year-old man diagnosed glioblastoma in 2003 went through 2 year's chemotherapy first. After emergency brain surgery he took acupuncture and Korean herbal medication including Dohongsamul-tang and Boan-Manyeongdan in addition to conventional radiotherapy and chemotherapy for 3 years. Since May 2008, he was exclusively treated with traditional Korean medicine except taking antiplatelets only for 9 years. Though he has sequelae of tumor necrosis such as facial palsy and hemiparesis, he has survived without recurrence more than 14 years. We suggest that integrative approach including traditional Korean medicine can be a meaningful treatment option for malignant brain tumor. Further studies with more cases should be performed to establish proper treatment protocol of integrative medicine for brain tumor.

교모세포종 진단을 받고 항암치료와 수술을 시행한 30대 남자에게 서양의학, 한의학적인 치료를 결합하여 시행한 결과, 현재 비록 치료 후유증인 편마비가 남아 있으나 이미 14년간 재발없이 장기간 생존함으로써 한방치료의 가능성을 보여 주었기에, 이에 증례를 보고한다.

Keywords

References

  1. Louis DN, Perry A, Reifenberger G, Deimling A, Figarella-Branger D, Cavenee WK, et al. The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a summary. Acta Neuropathol. 2016; DOI 10.1007/s00401-016-1545-1.
  2. Nicholas S, Mathios D, Ruzevick J, Jackson C, Yang I, Lim M. Current Trends in Glioblastoma Multiforme Treatment: Radiation Therapy and Immune Checkpoint Inhibitors. Brain Tumor Res Treat. 2013;1:2-8. https://doi.org/10.14791/btrt.2013.1.1.2
  3. Jung KW, Yoo H, Kong HJ, Won YJ, Park S, Lee SH. Population-based survival data for brain tumors in Korea. J neurooncol. 2012;109:301-307. https://doi.org/10.1007/s11060-012-0893-5
  4. Jeong JS, Park JW, Yoon SW. A Case of Metastatic Brain Tumor Patient with Nausea and Vomiting Treated with Gamibokryungbanha-tang. Korean J Orient Int Med. 2007;28(4):956-962.
  5. Jeong UM, Kim HM, Jeong JS, Lee JS, Kim KS, Yoon SW. A Case Report of Regressed Metastatic Brain Tumors and Prolongation of Life with Allergen Removed Rhus verniciflua Stokes after Gamma Knife Radiosurgery. J Korean Med. 2009;30(5):157-162.
  6. Kang Th, Won JH. Clinical Study on 1 Case of Patient with Astrocytoma. J Korea Oriental Oncology. 2000;6(1):181-188.
  7. Wang Z, Chen S, Wang L. A Comprehensive Curative Effect of Malignant Brain Tumors Treated With VM26+MeCCNU and TCM. Cancer Prev Treat Res. 2000;27(2):152-153.
  8. Zhou J, Liu H, Zhao M. Clinical research on Naoliu (Brain Tumor) powder in treating brain gliomas. Tianjin J Trad Chinese Med. 2008;25(4):277-280.
  9. Fan Y, Hu Y, Li Y. Antifebrile Effect of Naoreqing oral Liquid on Post-operational Fever of Glioma or Meningioma Patients. Cninese J Int Med. 2001;21(6):406-408.
  10. Zhang J. Analysis of Application of High Doses of Aconite Treatment of Typical Cases of Brain Tumor. Systems Med. 2016;1(4):60-63.
  11. Sun W, Cui J, Zhu Y, Cao Y, Sun Y, Wang Z. Discussion and Analysis of Contemporary Famous Chinese Medicine Experts' Clinical ExPeriences in Treating Brain Tumors. J Liaoning Univ TCM. 2014;16(4):59-60.
  12. Guo C, Zhu G. Summary of the Features of Qian Bowen's Thoughts on Clinical Treatment of Brain tumor. World Chinese Med. 2015;10(10):1552-1554.
  13. Dolecek TA, Propp JM, Stroup NE, Kruchko C. CBTRUS statistical report:primary brain and central nervous tumors diagnosed in the United States in 2005-2009. Neuro Oncol. 2012;14(suppl5):v1-v49. https://doi.org/10.1093/neuonc/nos218
  14. Do YS, Jung KW, Ha J, Seo Y, Park CK, Won YJ. et al. An Updated Nationwide Epidemiology of Primary Brain Tumors in Republic of Korea, 2013. Brain Tumor Res Treat. 2017;5(1):16-23. https://doi.org/10.14791/btrt.2017.5.1.16
  15. Omuro A, DeAngelis LM. Glioblastoma and Other Malignant Gliomas : A Clinical Review. JAMA. 2013;310(17):1842-1850. https://doi.org/10.1001/jama.2013.280319
  16. Chung M J, Park JY, Bang S, Park SW, Chung JB, Song SY. Phase II clinical trial to evaluate the efficacy and safety of activated T-lymphocyte cell therapy in gemcitabine refractory advanced pancreatic cancer. Pancreatology. 2013;13(4), S45.
  17. Shin YS, Lee JA, Bae SH, Lee SY, Jang MK. Investigation into the Use of Complementary and Alternative Medicine and Factors Affecting Use in Korean Patients with Brain Tumors. J Korean Acad Fundam Nurs. 2013;20(2):147-156. https://doi.org/10.7739/jkafn.2013.20.2.147
  18. Lee JK, Song YK, Lim HH. Analgesic and anti-inflammatory effect of Scutellaria baicalensis. J Korean Med. 2007;28(4):124-135.
  19. Lee HY, Kim JE, Kim M, Kim JH. A review of traditional Korean medical treatment for cancer-related cognitive impairment. J Korean Med. 2016;37(3):74-86. https://doi.org/10.13048/jkm.16036
  20. Verlut C, Mouillet G, Magnin E, Buffet-Miny J, Viennet G, Cattin F, et al. Age, Neurological Status MRC scale, and Postoperative Morbidity are Prognostic Factors in Patients with Glioblastoma Treated by Chemoradiotherapy. Clinical Med Insight: Oncology. 2016:1077-1082.

Cited by

  1. Research Trend about Complementary and Alternative Therapy in Korea using Text Network Analysis vol.21, pp.2, 2018, https://doi.org/10.7587/kjrehn.2018.61
  2. 교모세포종으로 항암화학치료 이후 설사를 호소하는 소음인 치험 1례 vol.31, pp.4, 2019, https://doi.org/10.7730/jscm.2019.31.4.65
  3. CARE 지침에 따른 대한한의학회지의 증례 보고에 대한 질 평가 연구: 2015년~2020년 증례 보고를 중심으로 vol.41, pp.2, 2018, https://doi.org/10.13048/jkm.20016
  4. CARE 지침에 따른 대한한의학회지의 증례보고에 대한 질 평가 vol.41, pp.2, 2018, https://doi.org/10.13048/jkm.20019