Journal of The Korean Society of Clinical Toxicology (대한임상독성학회지)

Korean society of Clincal Toxicology (대한임상독성학회)
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Relationship between Serum Neuron Specific Enolase Level and Seizure in Patients with Acute Glufosinate Ammonium Poisoning

급성 글루포시네이트 암모늄 중독환자에서 혈중 Neuron specific enolase 수치와 경련발생 간의 연관성

  • An, Gyo Jin (Department of Emergency Medicine, Yonsei University Wonju College of Medicine) ;
  • Lee, Yoonsuk (Department of Emergency Medicine, Yonsei University Wonju College of Medicine) ;
  • Chan, Yong Sung (Department of Emergency Medicine, Yonsei University Wonju College of Medicine) ;
  • Kim, Hyun (Department of Emergency Medicine, Yonsei University Wonju College of Medicine)
  • 안교진 (연세대학교 원주의과대학 응급의학교실) ;
  • 이윤석 (연세대학교 원주의과대학 응급의학교실) ;
  • 차용성 (연세대학교 원주의과대학 응급의학교실) ;
  • 김현 (연세대학교 원주의과대학 응급의학교실)
  • Received : 2018.05.29
  • Accepted : 2018.06.17
  • Published : 2018.06.30
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Abstract

Purpose: Glufosinate ammonium poisoning can cause seizures, even after a symptom-free period. This study was conducted to evaluate the relationship between serum neuron specific enolase (NSE) level and the occurrence of seizures in patients with acute glufosinate ammonium poisoning. Methods: For this retrospective observational study, data from patients diagnosed with acute glufosinate ammonium poisoning were collected between January 2016 and June 2016. Serum NSE was measured within 2 hours of arrival at the emergency department. The patients were divided into a seizure group and a non-seizure group. Results: The seizure group included eight of the 15 total patients (53.3%). The serum NSE level was significantly higher in the seizure group than in the non-seizure group ($32.4{\pm}11.9ng/mL$ vs. $19.5{\pm}5ng/mL$, p=0.019). The amount of glufosinate ingested and initial and peak serum ammonia levels were significantly higher in the seizure group than in the non-seizure group. There was no significant difference in the area under the curve of the serum NSE level or the initial and peak serum ammonia levels in terms of predicting the occurrence of seizures. Conclusion: In acute glufosinate poisoning, initial serum NSE levels may help in prediction of seizures.

Keywords

References

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