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Air pollution and climate change: Effects on asthmatic patients

대기오염과 기후 변화: 천식에 미치는 영향

  • Park, Hye-Kyung (Department of Internal Medicine, Pusan National University School of Medicine)
  • 박혜경 (부산대학교 의학전문대학원 내과학교실)
  • Received : 2017.09.06
  • Accepted : 2017.12.15
  • Published : 2018.03.31

Abstract

Along with increases in global warming and air pollution, increased asthma prevalence has been reported in most Westernized regions. Air pollutants enhance IgE-mediated response to aeroallergens and increased airway inflammation. Climate changes including global warming have impact on asthma in a variety of ways. Many epidemiologic studies have shown that climate factors including temperature and humidity influence the severity of symptoms and exacerbation in asthmatic patients. Climate changes can lead to deterioration of air pollution and increase the production and allergenicity of pollens which can enhance airway inflammation. In asthmatic patients, health effects from air pollution and climate changes are complex and may be difficult to assess separately. Herein, recent studies on air pollution and climate factors in asthma are reviewed.

Keywords

References

  1. Beggs PJ. Adaptation to impacts of climate change on aeroallergens and allergic respiratory diseases. Int J Environ Res Public Health 2010;7:3006-21. https://doi.org/10.3390/ijerph7083006
  2. Contribution of Working Groups I, II and III to the Fifth Assessment Report of the Intergovernmental Panel on Climate Change (Core Writing Team; Pachauri RK, Meyer LA, editors). Climate change 2014: synthesis report. Geneva (Switzerland); Intergovernmental Panel on Climate Change, 2015:151.
  3. D'Amato G, Liccardi G, D'Amato M, Cazzola M. Outdoor air pollution, climatic changes and allergic bronchial asthma. Eur Respir J 2002;20:763-76. https://doi.org/10.1183/09031936.02.00401402
  4. National Climate Data Service System [Internet] Daejeon (Korea): Korean Meteorological Administration. 1991-2016 [cited 2017 Mar 23]. Available from: http://www.index.go.kr/main.do.
  5. Atkinson RW, Anderson HR, Strachan DP, Bland JM, Bremner SA, Ponce de Leon A. Short-term associations between outdoor air pollution and visits to accident and emergency departments in London for respiratory complaints. Eur Respir J 1999;13:257-65. https://doi.org/10.1183/09031936.99.13225799
  6. Cacciola RR, Sarva M, Polosa R. Adverse respiratory effects and allergic susceptibility in relation to particulate air pollution: flirting with disaster. Allergy 2002;57:281-6. https://doi.org/10.1034/j.1398-9995.2002.1r3315.x
  7. Miller KA, Siscovick DS, Sheppard L, Shepherd K, Sullivan JH, Anderson GL, et al. Long-term exposure to air pollution and incidence of cardiovascular events in women. N Engl J Med 2007;356:447-58. https://doi.org/10.1056/NEJMoa054409
  8. Brunekreef B, Hoek G, Fischer P, Spieksma FT. Relation between airborne pollen concentrations and daily cardiovascular and respiratory-disease mortality. Lancet 2000;355:1517-8. https://doi.org/10.1016/S0140-6736(00)02168-1
  9. Kunzli N, Kaiser R, Medina S, Studnicka M, Chanel O, Filliger P, et al. Public-health impact of outdoor and traffic-related air pollution: a European assessment. Lancet 2000;356:795-801. https://doi.org/10.1016/S0140-6736(00)02653-2
  10. Bowatte G, Lodge C, Lowe AJ, Erbas B, Perret J, Abramson MJ, et al. The influence of childhood traffic-related air pollution exposure on asthma, allergy and sensitization: a systematic review and a meta-analysis of birth cohort studies. Allergy 2015;70:245-56. https://doi.org/10.1111/all.12561
  11. Silverman RA, Ito K. Age-related association of fine particles and ozone with severe acute asthma in New York City. J Allergy Clin Immunol 2010;125:367-73. https://doi.org/10.1016/j.jaci.2009.10.061
  12. Malig BJ, Green S, Basu R, Broadwin R. Coarse particles and respiratory emergency department visits in California. Am J Epidemiol 2013;178:58-69. https://doi.org/10.1093/aje/kws451
  13. Jo EJ, Lee WS, Jo HY, Kim CH, Eom JS, Mok JH, et al. Effects of particulate matter on respiratory disease and the impact of meteorological factors in Busan, Korea. Respir Med 2017;124:79-87. https://doi.org/10.1016/j.rmed.2017.02.010
  14. Park M, Luo S, Kwon J, Stock TH, Delclos G, Kim H, et al. Effects of air pollution on asthma hospitalization rates in different age groups in metropolitan cities of Korea. Air Qual Atmos Health 2013;6:543-51. https://doi.org/10.1007/s11869-013-0195-x
  15. Atkinson RW, Anderson HR, Sunyer J, Ayres J, Baccini M, Vonk JM, et al. Acute effects of particulate air pollution on respiratory admissions: results from APHEA 2 project. Air Pollution and Health: a European Approach. Am J Respir Crit Care Med 2001;164(10 Pt 1):1860-6. https://doi.org/10.1164/ajrccm.164.10.2010138
  16. Alhanti BA, Chang HH, Winquist A, Mulholland JA, Darrow LA, Sarnat SE. Ambient air pollution and emergency department visits for asthma: a multi-city assessment of effect modification by age. J Expo Sci Environ Epidemiol 2016;26:180-8. https://doi.org/10.1038/jes.2015.57
  17. Kim SH, Son JY, Lee JT, Kim TB, Park HW, Lee JH, et al. Effect of air pollution on acute exacerbation of adult asthma in Seoul, Korea: a case-crossover study. Korean J Med 2010;78:450-6.
  18. Kwon JW, Han YJ, Oh MK, Lee CY, Kim JY, Kim EJ, et al. Emergency Department visits for asthma exacerbation due to weather conditions and air pollution in Chuncheon, Korea: a case-crossover analysis. Allergy Asthma Immunol Res 2016;8:512-21. https://doi.org/10.4168/aair.2016.8.6.512
  19. D'Amato G. Airborne paucimicronic allergen-carrying particles and seasonal respiratory allergy. Allergy 2001;56:1109-11. https://doi.org/10.1034/j.1398-9995.2001.00317.x
  20. Nordenhall C, Pourazar J, Ledin MC, Levin JO, Sandstrom T, Adelroth E. Diesel exhaust enhances airway responsiveness in asthmatic subjects. Eur Respir J 2001;17:909-15. https://doi.org/10.1183/09031936.01.17509090
  21. Kim BJ, Lee SY, Kwon JW, Jung YH, Lee E, Yang SI, et al. Traffic-related air pollution is associated with airway hyperresponsiveness. J Allergy Clin Immunol 2014;133:1763-5.e2. https://doi.org/10.1016/j.jaci.2014.01.020
  22. Sacks JD, Rappold AG, Davis JA Jr, Richardson DB, Waller AE, Luben TJ. Influence of urbanicity and county characteristics on the association between ozone and asthma emergency department visits in North Carolina. Environ Health Perspect 2014;122:506-12.
  23. Lam HC, Li AM, Chan EY, Goggins WB 3rd. The short-term association between asthma hospitalisations, ambient temperature, other meteorological factors and air pollutants in Hong Kong: a time-series study. Thorax 2016;71:1097-109. https://doi.org/10.1136/thoraxjnl-2015-208054
  24. Strickland MJ, Darrow LA, Klein M, Flanders WD, Sarnat JA, Waller LA, et al. Short-term associations between ambient air pollutants and pediatric asthma emergency department visits. Am J Respir Crit Care Med 2010; 182:307-16. https://doi.org/10.1164/rccm.200908-1201OC
  25. Mar TF, Koenig JQ. Relationship between visits to emergency departments for asthma and ozone exposure in greater Seattle, Washington. Ann Allergy Asthma Immunol 2009;103:474-9. https://doi.org/10.1016/S1081-1206(10)60263-3
  26. Holz O, Mucke M, Paasch K, Bohme S, Timm P, Richter K, et al. Repeated ozone exposures enhance bronchial allergen responses in subjects with rhinitis or asthma Clin Exp Allergy 2002;32:681-9. https://doi.org/10.1046/j.1365-2222.2002.01358.x
  27. Vagaggini B, Taccola M, Cianchetti S, Carnevali S, Bartoli ML, Bacci E, et al. Ozone exposure increases eosinophilic airway response induced by previous allergen challenge. Am J Respir Crit Care Med 2002;166:1073-7. https://doi.org/10.1164/rccm.2201013
  28. McConnell R, Berhane K, Gilliland F, London SJ, Islam T, Gauderman WJ, et al. Asthma in exercising children exposed to ozone: a cohort study. Lancet 2002;359:386-91. https://doi.org/10.1016/S0140-6736(02)07597-9
  29. Chen KS, Ho YT, Lai CH, Tsai YA, Chen SJ. Trends in concentration of ground-level ozone and meteorological conditions during high ozone episodes in the Kao-Ping Airshed, Taiwan. J Air Waste Manag Assoc 2004;54:36-48. https://doi.org/10.1080/10473289.2004.10470880
  30. Bauer MA, Utell MJ, Morrow PE, Speers DM, Gibb FR. Inhalation of 0.30 ppm nitrogen dioxide potentiates exercise-induced bronchospasm in asthmatics. Am Rev Respir Dis 1986;134:1203-8.
  31. Goldstein IF, Lieber K, Andrews LR, Kazembe F, Foutrakis G, Huang P, et al. Acute respiratory effects of short-term exposures to nitrogen dioxide. Arch Environ Health 1988;43:138-42. https://doi.org/10.1080/00039896.1988.9935842
  32. Molter A, Agius R, de Vocht F, Lindley S, Gerrard W, Custovic A, et al. Effects of long-term exposure to PM10 and NO2 on asthma and wheeze in a prospective birth cohort. J Epidemiol Community Health 2014;68: 21-8. https://doi.org/10.1136/jech-2013-202681
  33. Tunnicliffe WS, Burge PS, Ayres JG. Effect of domestic concentrations of nitrogen dioxide on airway responses to inhaled allergen in asthmatic patients. Lancet 1994;344:1733-6. https://doi.org/10.1016/S0140-6736(94)92886-X
  34. Hazucha MJ, Ginsberg JF, McDonnell WF, Haak ED Jr, Pimmel RL, Salaam SA, et al. Effects of 0.1 ppm nitrogen dioxide on airways of normal and asthmatic subjects. J Appl Physiol Respir Environ Exerc Physiol 1983; 54:730-9.
  35. Khreis H, Kelly C, Tate J, Parslow R, Lucas K, Nieuwenhuijsen M. Exposure to traffic-related air pollution and risk of development of childhood asthma: a systematic review and meta-analysis. Environ Int 2017;100:1-31. https://doi.org/10.1016/j.envint.2016.11.012
  36. Cai Y, Zijlema WL, Doiron D, Blangiardo M, Burton PR, Fortier I, et al. Ambient air pollution, traffic noise and adult asthma prevalence: a BioSHaRE approach. Eur Respir J 2017;49(1). pii: 1502127. https://doi.org/10.1183/13993003.02127-2015.
  37. Bowatte G, Lodge CJ, Knibbs LD, Lowe AJ, Erbas B, Dennekamp M, et al. Traffic-related air pollution exposure is associated with allergic sensitization, asthma, and poor lung function in middle age. J Allergy Clin Immunol 2017;139:122-9. https://doi.org/10.1016/j.jaci.2016.05.008
  38. Sheppard D, Wong WS, Uehara CF, Nadel JA, Boushey HA. Lower threshold and greater bronchomotor responsiveness of asthmatic subjects to sulfur dioxide. Am Rev Respir Dis 1980;122:873-8.
  39. Kehrl HR, Roger LJ, Hazucha MJ, Horstman DH. Differing response of asthmatics to sulfur dioxide exposure with continuous and intermittent exercise. Am Rev Respir Dis 1987;135:350-5.
  40. Sheppard D, Saisho A, Nadel JA, Boushey HA. Exercise increases sulfur dioxide-induced bronchoconstriction in asthmatic subjects. Am Rev Respir Dis 1981;123:486-91.
  41. Winterton DL, Kaufman J, Keener CV, Quigley S, Farin FM, Williams PV, et al. Genetic polymorphisms as biomarkers of sensitivity to inhaled sulfur dioxide in subjects with asthma. Ann Allergy Asthma Immunol 2001;86:232-8. https://doi.org/10.1016/S1081-1206(10)62697-X
  42. Khalaj B, Lloyd G, Sheppeard V, Dear K. The health impacts of heat waves in five regions of New South Wales, Australia: a case-only analysis. Int Arch Occup Environ Health 2010;83:833-42. https://doi.org/10.1007/s00420-010-0534-2
  43. Soneja S, Jiang C, Fisher J, Upperman CR, Mitchell C, Sapkota A. Exposure to extreme heat and precipitation events associated with increased risk of hospitalization for asthma in Maryland, U.S.A. Environ Health 2016;15:57. https://doi.org/10.1186/s12940-016-0142-z
  44. Wang YC, Lin YK. Temperature effects on outpatient visits of respiratory diseases, asthma, and chronic airway obstruction in Taiwan. Int J Biometeorol 2015;59:815-25. https://doi.org/10.1007/s00484-014-0899-0
  45. Beard JD, Beck C, Graham R, Packham SC, Traphagan M, Giles RT, et al. Winter temperature inversions and emergency department visits for asthma in Salt Lake County, Utah, 2003-2008. Environ Health Perspect 2012;120:1385-90. https://doi.org/10.1289/ehp.1104349
  46. Kim S, Kim Y, Lee MR, Kim J, Jung A, Park JS, et al. Winter season temperature drops and sulfur dioxide levels affect on exacerbation of refractory asthma in South Korea: a time-trend controlled case-crossover study using soonchunhyang asthma cohort data. J Asthma 2012;49:679-87. https://doi.org/10.3109/02770903.2012.702839
  47. Son JY, Bell ML, Lee JT. The impact of heat, cold, and heat waves on hospital admissions in eight cities in Korea. Int J Biometeorol 2014;58:1893-903. https://doi.org/10.1007/s00484-014-0791-y
  48. Kim J, Lim Y, Kim H. Outdoor temperature changes and emergency department visits for asthma in Seoul, Korea: a time-series study. Environ Res 2014;135:15-20. https://doi.org/10.1016/j.envres.2014.07.032
  49. Qiu H, Yu IT, Tse LA, Chan EY, Wong TW, Tian L. Greater temperature variation within a day associated with increased emergency hospital admissions for asthma. Sci Total Environ 2015;505:508-13. https://doi.org/10.1016/j.scitotenv.2014.10.003
  50. D'Amato G, Liccardi G, Frenguelli G. Thunderstorm-asthma and pollen allergy. Allergy 2007;62:11-6. https://doi.org/10.1111/j.1398-9995.2006.01271.x
  51. D'Amato G, Cecchi L, Annesi-Maesano I. A trans-disciplinary overview of case reports of thunderstorm-related asthma outbreaks and relapse. Eur Respir Rev 2012;21:82-7. https://doi.org/10.1183/09059180.00001712
  52. Dales RE, Cakmak S, Judek S, Dann T, Coates F, Brook JR, et al. The role of fungal spores in thunderstorm asthma. Chest 2003;123:745-50. https://doi.org/10.1378/chest.123.3.745
  53. Pulimood TB, Corden JM, Bryden C, Sharples L, Nasser SM. Epidemic asthma and the role of the fungal mold Alternaria alternata. J Allergy Clin Immunol 2007;120:610-7. https://doi.org/10.1016/j.jaci.2007.04.045
  54. Ziska LH, Beggs PJ. Anthropogenic climate change and allergen exposure: the role of plant biology. J Allergy Clin Immunol 2012;129:27-32. https://doi.org/10.1016/j.jaci.2011.10.032
  55. D'Amato G, Cecchi L, Bonini S, Nunes C, Annesi-Maesano I, Behrendt H, et al. Allergenic pollen and pollen allergy in Europe. Allergy 2007;62: 976-90. https://doi.org/10.1111/j.1398-9995.2007.01393.x
  56. Steinvil A, Fireman E, Kordova-Biezuner L, Cohen M, Shapira I, Berliner S, et al. Environmental air pollution has decremental effects on pulmonary function test parameters up to one week after exposure. Am J Med Sci 2009;338:273-9. https://doi.org/10.1097/MAJ.0b013e3181adb3ed
  57. Kim JH, Oh JW, Lee HB, Kim SW, Chung HL, Kook MH, et al. Evaluation of the association of vegetation of allergenic plants and pollinosis with meteorological changes. Allergy Asthma Respir Dis 2014;2:48-58. https://doi.org/10.4168/aard.2014.2.1.48
  58. Motta AC, Marliere M, Peltre G, Sterenberg PA, Lacroix G. Traffic-related air pollutants induce the release of allergen-containing cytoplasmic granules from grass pollen. Int Arch Allergy Immunol 2006;139:294-8. https://doi.org/10.1159/000091600

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