The Korean journal of internal medicine

  • 제33권2호
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  • Pages.367-382
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  • 2018
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  • 1226-3303(pISSN)
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  • 2005-6648(eISSN)
대한내과학회 (The Korean Association of Internal Medicine)
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DOI QR코드

DOI QR Code

Long-term study of the association of adipokines and glucose variability with diabetic complications

  • Cha, Jin Joo (Department of Nephrology, Korea University Ansan Hospital) ;
  • Min, Hye Sook (Department of Nephrology, Korea University Ansan Hospital) ;
  • Kim, Kitae (Department of Nephrology, Korea University Ansan Hospital) ;
  • Lee, Mi Jin (Department of Nephrology, Korea University Ansan Hospital) ;
  • Lee, Mi Hwa (Department of Nephrology, Korea University Ansan Hospital) ;
  • Kim, Jung Eun (Department of Nephrology, Korea University Ansan Hospital) ;
  • Song, Hye Kyoung (Department of Nephrology, Korea University Ansan Hospital) ;
  • Cha, Dae Ryong (Department of Nephrology, Korea University Ansan Hospital) ;
  • Kang, Young Sun (Department of Nephrology, Korea University Ansan Hospital)
  • 투고 : 2016.04.11
  • 심사 : 2016.06.06
  • 발행 : 2018.03.01
⟨ 이전 논문 다음 논문 ⟩

초록

Background/Aims: Recent studies have suggested an important role of adipokines in the development of insulin resistance and diabetes mellitus. The clinical relevance of adipokines on long-term outcomes in patients with diabetes and chronic kidney disease is uncertain. The purpose of this study was to identify a predictable factor in patients with long-term diabetic complications. Methods: A total of 161 diabetic individuals were followed-up from 2002 to 2013. Circulating plasma levels of adiponectin, glypican-4, irisin, visfatin, and visit-to-visit glucose variability were measured in diabetic patients. Associations among adipokines and variable metabolic parameters and microvascular, and macrovascular complications were evaluated. Results: Plasma adiponectin and glypican-4 levels were significantly increased in patients with renal insufficiency. These adipokines were negatively associated with estimated glomerular filtration rate and positively associated with urinary albumin excretion. The relative risk of renal progression to dialysis increased independently with increasing level of adiponectin. Glypican-4 and visfatin were not predictive of any microvascular or macrovascular complications. Glucose variability increased the risk of diabetic nephropathy and cerebrovascular complications. Conclusions: Adiponectin and glypican-4 were associated with renal function and might be able to predict renal progression. Glucose variability was a predictable factor for diabetic nephropathy and cerebrovascular complications.

키워드

과제정보

연구 과제 주관 기관 : Korea University

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피인용 문헌

  1. Adipocytokines and new onset diabetes mellitus after transplantation vol.16, pp.4, 2018, https://doi.org/10.1016/j.jab.2018.05.005
  2. Adiponectin for the treatment of diabetic nephropathy vol.34, pp.3, 2019, https://doi.org/10.3904/kjim.2019.109
  3. Relationship between diabetic polyneuropathy, serum visfatin, and oxidative stress biomarkers vol.11, pp.7, 2018, https://doi.org/10.4239/wjd.v11.i7.309
  4. Fasting Glucose of 6.1 mmol/L as a Possible Optimal Target for Type 2 Diabetic Patients with Insulin Glargine: A Randomized Clinical Trial vol.2021, pp.None, 2018, https://doi.org/10.1155/2021/5524313
  5. Glypican-4 in pregnancy and its relation to glucose metabolism, insulin resistance and gestational diabetes mellitus status vol.11, pp.1, 2018, https://doi.org/10.1038/s41598-021-03454-x
  6. Fasting Glucose Variability as a Risk Indicator for End-Stage Kidney Disease in Patients with Diabetes: A Nationwide Population-Based Study vol.10, pp.24, 2018, https://doi.org/10.3390/jcm10245948