Journal of radiological science and technology (대한방사선기술학회지:방사선기술과학)

Korean Society of Radiological Science (대한방사선과학회)
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Radiation Protective Effect of Selenium and Folic Acid Mixtures in the Development of Congenital Anomalies Following Radiation Exposure to the Fetus of Perinatal Female White Rats

주산기 암컷 백서의 태아에 방사선피폭에 따른 선천성기형 발생 시 셀레늄과 엽산 혼합물의 방사선 방호효과

  • Jung, Do-Young (Department of Emergency Management, Inje University) ;
  • Choi, Hyung-Seok (Department of Emergency Management, Inje University) ;
  • Kim, Jang-Oh (Department of Emergency Management, Inje University) ;
  • Shin, Ji-Hye (Department of Emergency Management, Inje University) ;
  • Kim, Joo-Hee (Department of Emergency Management, Inje University) ;
  • Park, Gyeong-Jin (Department of Emergency Management, Inje University) ;
  • Min, Byung-In (Department of Nuclear Applied Engineering, Inje University)
  • 정도영 (인제대학교 재난관리학과) ;
  • 최형석 (인제대학교 재난관리학과) ;
  • 김장오 (인제대학교 재난관리학과) ;
  • 신지혜 (인제대학교 재난관리학과) ;
  • 김주희 (인제대학교 재난관리학과) ;
  • 박경진 (인제대학교 재난관리학과) ;
  • 민병인 (인제대학교 원자력응용공학부)
  • Received : 2018.03.09
  • Accepted : 2018.04.24
  • Published : 2018.04.30
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Abstract

This study is a search for radiation protection effects of radiation exposure on the organogenic period during the prenatal period, which is known to be the most likely to have congenital malformations by radiation exposure. To study the radiation protection for the mixture of selenium that is strong antioxidant and folic acid that is essential vitamin for DNA synthesis, 2 Gy of radiation was irradiated to pregnant female rats. then, after 14 days of fetal birth, observing blood components, SOD(Superoxide Dismutase), histological changes and external malformations. There was a significant protective effect to reduce blood cell damage(p<0.05) in the irradiation group after selenium and folic acid mixture were administered than irradiation group, and the activation of SOD which is antioxidant enzymes was increased. In addition, confirmed the effect of suppressing the expression of apoptosis of small intestinal cells and the reduction of cerebral cortex layer reduction by radiation. thus, it was confirmed that the congenital malformations were reduced as a result of these protective effects. Based on these results, selenium and folic acid mixture may reduce the incidence of congenital malformations, and it will reduce the damage of the fetus caused by the exposure of the organogenic period due to accidents.

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References

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