식품과학과 산업 (Food Science and Industry)

한국식품과학회 (Korean Society of Food Science and Technology)
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마우스를 이용한 비만연구에서 활용되는 물리적 표현형 분석 기술

Physical Phenotype Analysis in Obesity Study in vivo

  • 김현경 (한양대학교 식품영양학과) ;
  • 고광웅 (한양대학교 식품영양학과)
  • 투고 : 2018.03.09
  • 심사 : 2018.03.22
  • 발행 : 2018.03.31
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초록

The prevalence of obesity is continually increasing in South Korea; about 1/3 of adults are diagnosed with obesity and 1/2 of adults are overweight in 2016. Abnormal body fat mass increased the risk factors of metabolic syndrome (including hypertension, type II diabetes, dyslipidemia), chronic kidney failure, osteoarthritis, and cardiovascular disease. Ministry of Food and Drug Safety (MFDS) in Korea established the validation and approval system for "functional food" based on related laws and regulations. According to the guideline of MFDS, the biomarkers for obesity study in vitro, in vivo, and clinical trial are well summarized. The analysis of physical phenotypes is necessary condition to study further molecular phenotypes and pathway analysis in vivo study. Thus, we will review currently available physical phenotype analysis; dual energy X-ray absorptiometry (DEXA) and Oxylet gas analysis will be examined in-depth.

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참고문헌

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