Korean Journal of Psychosomatic Medicine (정신신체의학)

Korean Psychosomatic Society (한국정신신체의학회)
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Association between Insulin Resistance and Depression in the General Korean Population : Cross Sectional Findings from the National Health and Nutrition Examination Survey

한국 성인에서 인슐린 저항성과 우울증의 연관성

  • Lee, Yoon-Ho (Department of Psychiatry, Busan Paik Hospital, Inje University College of Medicine) ;
  • Jung, Do-Un (Department of Psychiatry, Busan Paik Hospital, Inje University College of Medicine) ;
  • Kim, Sung-Jin (Department of Psychiatry, Busan Paik Hospital, Inje University College of Medicine) ;
  • Kang, Je-Wook (Department of Psychiatry, Busan Paik Hospital, Inje University College of Medicine) ;
  • Moon, Jung-Joon (Department of Psychiatry, Busan Paik Hospital, Inje University College of Medicine) ;
  • Jeon, Dong-Wook (Department of Psychiatry, Busan Paik Hospital, Inje University College of Medicine) ;
  • Kim, You-Na (Department of Psychiatry, Busan Paik Hospital, Inje University College of Medicine) ;
  • Lee, Chung-Yeal (Department of Psychiatry, Busan Paik Hospital, Inje University College of Medicine) ;
  • Park, Sung-Young (Department of Psychiatry, Busan Paik Hospital, Inje University College of Medicine)
  • 이윤호 (인제대학교 의과대학 부산백병원 정신건강의학교실) ;
  • 정도운 (인제대학교 의과대학 부산백병원 정신건강의학교실) ;
  • 김성진 (인제대학교 의과대학 부산백병원 정신건강의학교실) ;
  • 강제욱 (인제대학교 의과대학 부산백병원 정신건강의학교실) ;
  • 문정준 (인제대학교 의과대학 부산백병원 정신건강의학교실) ;
  • 전동욱 (인제대학교 의과대학 부산백병원 정신건강의학교실) ;
  • 김유나 (인제대학교 의과대학 부산백병원 정신건강의학교실) ;
  • 이충열 (인제대학교 의과대학 부산백병원 정신건강의학교실) ;
  • 박성용 (인제대학교 의과대학 부산백병원 정신건강의학교실)
  • Received : 2018.07.06
  • Accepted : 2018.09.11
  • Published : 2018.12.31
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Abstract

Objectives : The purpose of this study was to investigate the association between the insulin resistance and depressive mood, suicidal ideation, psychological stress, and quality of life in general Korean population. Methods : We selected 3,613 subjects from the third year's data of 6th Korean National Health and Nutritional Examination Survey. Insulin resistance was evaluated with Homeostatic Model Assessment of Insulin Resistance. Questionnaires on depressive mood, suicidal ideation and psychological stress were conducted. The quality of life was assessed with the EuroQol-5 dimension index. We used correlation and regression analysis for analysis. Results : The risk of depressive mood and suicidal ideation was significantly higher in the insulin resistance group than in the control group. The risk of psychological stress was significantly higher in the male group with insulin resistance. The EuroQol-5 dimension index showed a negative correlation with insulin resistance. After adjusting for age, sex and body mass index, increased risk of suicidal ideation was identified only. Conclusions : We confirmed that insulin resistance is associated to mental health problems related with depression in Korean adults.

연구목적 본 연구는 한국 성인의 인슐린 저항성 정도와 우울감, 자살 생각, 스트레스 및 삶의 질 사이의 연관성을 탐색하고자 하였다. 방 법 제6기 3차년도 국민건강영양조사 자료를 이용하여 3,613명의 대상자를 선정하였다. 인슐린 저항성은 Homeostatic Model Assessment of Insulin Resistance를 통해 계산하였다. 우울감, 자살 생각, 스트레스에 대한 설문이 이루어졌으며, 삶의 질은 EuroQol-5 dimension의 삶의 질 지수를 통해 평가되었다. 분석 방법으로는 상관 분석과 회귀 분석이 사용되었다. 결 과 인슐린 저항성 집단에서 대조 집단에 비해 우울감과 자살 생각의 위험성이 유의하게 높았다. 스트레스는 남성에서만 인슐린 저항성 집단에서 위험성이 유의하게 증가하였다. 삶의 질 지수는 인슐린 저항성과 음의 상관관계를 보였다. 나이, 성별, 체질량 지수를 보정하였을 경우에는 자살 생각에서만 위험성 증가가 확인되었다 결 론 한국 성인에서 인슐린 저항성이 우울증과 관련된 정신건강 문제들과 연관성을 갖는 것을 확인하였다.

Keywords

Table 1. Demographic and clinical characteristics of study participants (n=3,613)

JSSCBG_2018_v26n2_86_t0001.png 이미지

Table 2. The association between insulin resistance† and depression, suicidal ideation and psychological stress in study participants

JSSCBG_2018_v26n2_86_t0002.png 이미지

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