대한화학회지 (Journal of the Korean Chemical Society)

  • 제62권2호
  • /
  • Pages.87-92
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  • 2018
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  • 1017-2548(pISSN)
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  • 2234-8530(eISSN)
대한화학회 (Korean Chemical Society)
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Synthesis and Antimicrobial Screening of Pyrimidine Annulated Dihydropyrano[2, 3-c]pyrazole Derivatives

  • Hegde, Hemant (Department of Chemistry, Manipal Institute of Technology) ;
  • Ahn, Chuljin (Department of Chemistry, Changwon National University) ;
  • Waribam, Preeti (Department of Chemistry, Manipal Institute of Technology) ;
  • Shetty, Nitinkumar S. (Department of Chemistry, Manipal Institute of Technology)
  • 투고 : 2017.10.26
  • 심사 : 2018.01.08
  • 발행 : 2018.04.20
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초록

A series of pyrimidine annulated dihydropyrano[2, 3-c]pyrazole derivatives were synthesized and screened for their antimicrobial activity. The precursor, dihydropyrano[2, 3-c]pyrazole was synthesised under catalyst free condition using PEG-400 as reaction medium which facilitated improved yield compared to base catalyzed reaction. Wide scope of substrates, simple workup procedure and high yield even in the absence of catalyst are the major highlights of the protocol. Dihydropyrano[2, 3-c]pyrazoles on condensation with formic acid formed pyrimidine annulated dihydropyrano[2, 3-c]pyrazole derivatives. All the products are characterized using FTIR, $^1H-NMR$ and $^{13}C-NMR$ spectroscopic techniques. The molecules have shown good to moderate activity as antimicrobial agents when compared to the standard drug ciprofloxacin.

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피인용 문헌

  1. Design, Synthesis, and Biological Evaluation of Densely Substituted Dihydropyrano[2,3-c]pyrazoles via a Taurine-Catalyzed Green Multicomponent Approach vol.6, pp.45, 2018, https://doi.org/10.1021/acsomega.1c04773