Journal of the Korean Society of Laryngology, Phoniatrics and Logopedics (대한후두음성언어의학회지)

The Korean Society of Laryngology, Phoniatrics and Logopedics. (대한후두음성언어의학회)
권호 표지

Multicenter Evaluation on the Efficacy of N-Acetyl Cystine in Relieving the Symptoms of Laryngopharyngeal Reflux Disease

인후두 역류질환에서 N-Acetyl Cysteine의 증상 개선 효과에 대한 다기관 평가

  • Kim, So Yean (Department of Otorhinolaryngology-Head and Neck Surgery, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine) ;
  • Kwon, Tack Kyun (Department of Otorhinolaryngology, Seoul National University College of Medicine) ;
  • Kim, Han Su (Department of Otorhinolaryngology-Head and Neck Surgery, Ewha Womans University School of Medicine) ;
  • Son, Young Ik (Department of Otorhinolaryngology-Head and Neck Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine) ;
  • Woo, Seung Hoon (Department of Otorhinolaryngology, Gyeongsang National University School of Medicine) ;
  • Woo, Jeong-Soo (Department of Otorhinolaryngology-Head and Neck Surgery, Korea University College of Medicine,) ;
  • Lee, Seung Won (Department of Otorhinolaryngology-Head and Neck Surgery, Soonchunhyang University College of Medicine) ;
  • Lim, Jae Yol (Department of Otorhinolaryngology, Gangnam Severance Hospital, Yonsei University College of Medicine) ;
  • Chung, Man Ki (Department of Otorhinolaryngology-Head and Neck Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine) ;
  • Joo, Young Hoon (Department of Otolaryngology-Head and Neck Surgery, Bucheon St. Mary's Hospital, College of Medicine, The Catholic University of Korea) ;
  • Cha, Wonjae (Department of Otorhinolaryngology-Head and Neck Surgery, Pusan National University Hospital, Pusan National University School of Medicine) ;
  • Choi, Seung Ho (Department of Otolaryngology, Asan Medical Center, University of Ulsan College of Medicine) ;
  • Hong, Hyun Jun (Department of Otorhinolaryngology-Head & Neck Surgery, International St. Mary's Hospital, Catholic Kwandong University College of Medicine) ;
  • Lee, Sang Hyuk (Department of Otorhinolaryngology-Head and Neck Surgery, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine)
  • 김소연 (성균관대학교 의과대학 강북삼성병원 이비인후과학교실) ;
  • 권택균 (서울대학교 의과대학 이비인후과학교실) ;
  • 김한수 (이화여자대학교 의과대학 이비인후과학교실) ;
  • 손영익 (성균관대학교 의과대학 삼성서울병원 이비인후과학교실) ;
  • 우승훈 (경상대학교 의과대학 이비인후과학교실) ;
  • 우정수 (고려대학교 의과대학 구로병원 이비인후과학교실) ;
  • 이승원 (순천향대학교 의과대학 부천병원 이비인후과학교실) ;
  • 임재열 (연세대학교 의과대학 강남세브란스병원 이비인후과학교실) ;
  • 정만기 (성균관대학교 의과대학 삼성서울병원 이비인후과학교실) ;
  • 주영훈 (가톨릭대학교 의과대학 부천성모병원 이비인후과학교실) ;
  • 차원재 (부산대학교 의과대학 이비인후과학교실) ;
  • 최승호 (울산대학교 의과대학 서울아산병원 이비인후과학교실) ;
  • 홍현준 (가톨릭관동대학교 의과대학 이비인후과학교실) ;
  • 이상혁 (성균관대학교 의과대학 강북삼성병원 이비인후과학교실)
  • Received : 2018.10.25
  • Accepted : 2018.11.08
  • Published : 2018.12.30
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Abstract

Background and Objectives : Laryngopharyngeal reflux disease (LPRD) is relatively common disease. N-acetyl cysteine (NAC) has both mucolytic and antioxidant effect, also may be beneficial in inflammatory airway diseases. The purpose of this study was to evaluate the efficacy and safety of inhaled NAC therapy in LPRD. Materials and Method : We retrospectively reviewed the medical records of 525 LPRD patients at 12 medical centers. Finally 401 patients subjected to inhaled NAC therapy for 2 months were enrolled in the study. We analyzed the change of Reflux Symptom Index (RSI) and Reflux Finding Score (RFS) after use of NAC for 4 weeks and 8 weeks in addition to the patient's compliance of the treatment. Results : The RSI score significantly decreased from $19.87{\pm}6.34$ to $12.78{\pm}6.93$ after 4 weeks and to $10.65{\pm}7.47$ after 8 weeks. The RFS score also significantly decreased from $9.29{\pm}3.4$ to $7.17{\pm}3.41$ after 4 weeks and to $6.1{\pm}3.73$ after 8 weeks (p<0.05). During the treatment periods, 42 patients (10.4%) reported to have 80 episodes of discomfort. Throat discomfort (33%) and nausea (28%) were most common complaints, but the duration of discomfort was usually less than 4 weeks. Conclusion : Inhaled NAC treatment is highly effective for the reduction of both subjective and objective findings in LPRD patients. This study will provide the evidence of new treatment option for patients with LPRD. However, further studies will be needs to assess the real effect of inhaled NAC therapy as a standard treatment regimen of LPRD.

Keywords

References

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